 Fenretinide
"Fenretinide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.
| Descriptor ID |
D017313
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| MeSH Number(s) |
D02.455.326.271.665.202.495.270 D02.455.426.392.368.367.379.249.700.270 D02.455.849.131.495.270 D23.767.261.700.270
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| Concept/Terms |
Fenretinide- Fenretinide
- N-(4-Hydroxyphenyl)-trans-Retinamide
- Fenretinimide
- N-(4-Hydroxyphenyl)retinamide
- 4-HPR
- 4-Hydroxyphenylretinamide
- 4 Hydroxyphenylretinamide
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Below are MeSH descriptors whose meaning is more general than "Fenretinide".
Below are MeSH descriptors whose meaning is more specific than "Fenretinide".
This graph shows the total number of publications written about "Fenretinide" by people in this website by year, and whether "Fenretinide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2010 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fenretinide" by people in Profiles.
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Mukherjee N, Reuland SN, Lu Y, Luo Y, Lambert K, Fujita M, Robinson WA, Robinson SE, Norris DA, Shellman YG. Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells. J Invest Dermatol. 2015 Mar; 135(3):842-850.
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Hail N, Chen P, Wempe MF. The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells. Free Radic Biol Med. 2010 Dec 15; 49(12):2001-9.
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Hail N, Chen P, Kepa JJ, Bushman LR, Shearn C. Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis. Free Radic Biol Med. 2010 Jul 01; 49(1):109-16.
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Poot M, Hosier S, Swisshelm K. Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells. Exp Cell Res. 2002 Sep 10; 279(1):128-40.
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Swisshelm K, Ryan K, Tsuchiya K, Sager R. Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4472-6.
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Swisshelm K, Ryan K, Lee X, Tsou HC, Peacocke M, Sager R. Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 1994 Feb; 5(2):133-41.
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