 PPAR alpha
"PPAR alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
| Descriptor ID |
D047493
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| MeSH Number(s) |
D12.776.826.239.500
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| Concept/Terms |
PPAR alpha- PPAR alpha
- Peroxisome Proliferator-Activated Receptor alpha
- Peroxisome Proliferator Activated Receptor alpha
- PPARalpha
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Below are MeSH descriptors whose meaning is more general than "PPAR alpha".
Below are MeSH descriptors whose meaning is more specific than "PPAR alpha".
This graph shows the total number of publications written about "PPAR alpha" by people in this website by year, and whether "PPAR alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 5 | 6 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2014 | 2 | 0 | 2 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 2 | 2 | | 2019 | 1 | 2 | 3 | | 2020 | 0 | 1 | 1 | | 2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "PPAR alpha" by people in Profiles.
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Grobbee EJ, de Jong VD, Schrieks IC, Tushuizen ME, Holleboom AG, Tardif JC, Lincoff AM, Schwartz GG, Castro Cabezas M, Grobbee DE. Improvement of non-invasive tests of liver steatosis and fibrosis as indicators for non-alcoholic fatty liver disease in type 2 diabetes mellitus patients with elevated cardiovascular risk profile using the PPAR-a/? agonist aleglitazar. PLoS One. 2022; 17(11):e0277706.
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Romic S, Tepavcevic S, Popovic T, Zec M, Stojiljkovic M, Culafic T, Bo?kovic M, Koricanac G. Consumption of walnuts suppresses the conversion of palmitic to palmitoleic acid and enhances omega-3 fatty acid metabolism in the heart of fructose-fed rats. Int J Food Sci Nutr. 2022 Nov; 73(7):940-953.
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Mandala A, Dobrinskikh E, Janssen RC, Fiehn O, D'Alessandro A, Friedman JE, Jonscher KR. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. Int J Mol Sci. 2022 May 27; 23(11).
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Hutch CR, Trakimas DR, Roelofs K, Pressler J, Sorrell J, Cota D, Obici S, Sandoval DA. Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy. Ann Surg. 2020 03; 271(3):509-518.
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Koomen JV, Heerspink HJL, Schrieks IC, Schwartz GG, Lincoff AM, Nicholls SJ, Svensson A, Wedel H, Weichert A, Grobbee DE, Stevens J. Exposure and response analysis of aleglitazar on cardiovascular risk markers and safety outcomes: An analysis of the AleCardio trial. Diabetes Obes Metab. 2020 01; 22(1):30-38.
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Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Despr?s JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nu?ez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner ?, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokg?zoglu LS, Tomlinson B, Tybj?rg-Hansen A, Valensi P, Vrabl?k M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71.
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Iwaki T, Bennion BG, Stenson EK, Lynn JC, Otinga C, Djukovic D, Raftery D, Fei L, Wong HR, Liles WC, Standage SW. PPARa contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis. Physiol Rep. 2019 05; 7(10):e14078.
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Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Glycogen Synthase Kinase-3a Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019 05 07; 29(5):1119-1134.e12.
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Lyons DN, Zhang L, Danaher RJ, Miller CS, Westlund KN. PPAR? Agonists Attenuate Trigeminal Neuropathic Pain. Clin J Pain. 2017 12; 33(12):1071-1080.
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Ronis M, Mercer K, Engi B, Pulliam C, Zimniak P, Hennings L, Shearn C, Badger T, Petersen D. Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis. Am J Pathol. 2017 Feb; 187(2):418-430.
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