Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Elizabeth J Kovacs

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG
Phone303/724-8243
ORCID ORCID Icon0000-0002-9459=9928 Additional info

    Collapse Research 
    Collapse research activities and funding
    F32 AG023443-01     (Walrath, Travis)Apr 1, 2023 - Mar 31, 2025
    Co-sponsor with N Quillinan and M Patel
    The gut-brain axis at the intersection of aging and traumatic injury
    F31 AA030213-01A1     (Paige Anton, PhD student, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy)Sep 1, 2022 - Aug 31, 2025
    Co-Sponsor with R McCullough and M. Patel
    The neuroinflammatory impact of binge ethanol exposure in aged mice: Investigating microglia NLRP3 regulation
    GM136444     (Pekeris, Rytis)Jul 1, 2022 - Jun 30, 2023

    Ethanol, burn and lung antimicrobial peptides
    R21 AA028904-01A1     ((P.I., Mayumi Fujita, MD) Co-Investigator)Aug 31, 2021 - Jul 30, 2023
    NIH
    Ethanol induced skin changes
    R13AA028908     (KOVACS, ELIZABETH J.)Feb 20, 2021 - Jan 31, 2024
    NIH
    2021 and 2023 Alcohol-Induced End Organ Diseases Gordon Research Conference
    Role: Principal Investigator
    R01 AG018859-18     (Kovacs, Elizabeth)Sep 30, 2020 - May 31, 2025
    NIH
    Aging, macrophage mediators, and burn trauma.
    R35GM131831     (KOVACS, ELIZABETH J.)Sep 20, 2019 - Jun 30, 2029
    NIH
    Alcohol and Burn Trauma: Multi-organ Inflammatory Responses
    Role: Principal Investigator
    K08 GM134185-04     Sep 15, 2019 - Aug 31, 2024
    Juan-Pablo Idrovo, MD
    Hepatic response in advance age after burn injury
    I01 BX004335-04     (Kovacs, Elizabeth)Apr 1, 2019 - Mar 31, 2024
    NIH
    Multi-organ Inflammatory Response after Burn Trauma
    R13 AA020768-09     (Multi-P.I. with Mashkoor A. Choudhry)Mar 1, 2019 - Feb 28, 2023
    NIH
    Alcohol and Immunology Research Interest Group (AIRIG) Meetings
    R21AA026295     (KOVACS, ELIZABETH J.)Sep 5, 2018 - Aug 31, 2021
    NIH
    Alcohol and Lung Immunity in the Aged
    Role: Principal Investigator
    R24 AA019661-08     (Ellen L Burnham, MD, MS (Co-Investigator))May 5, 2018 - Mar 31, 2023
    NIH
    Clinical resource for lung and alcohol investigations
    K01 AG058810-04     Mar 1, 2018 - Nov 30, 2023
    Danielle R. Bruns, PhD, Assistant Professor, Division of Kinesiology and Health, University of Wyoming - Co-sponsor, Lori Watkins and Mary Weiser-Evans
    Therapeutic activation of AMPK for the aging right heart
    R21AA023193     (KOVACS, ELIZABETH J.)Jun 1, 2015 - May 31, 2019
    NIH
    Binge alcohol intoxication, mesenchymal stem cells and lung inflammation
    Role: Principal Investigator
    P30AA019373     (KOVACS, ELIZABETH J)Sep 30, 2009 - Aug 31, 2012
    NIH
    Loyola Alcohol Research Center (LARC)
    Role: Principal Investigator
    R21AI073987     (KOVACS, ELIZABETH J)Aug 13, 2009 - Jul 31, 2011
    NIH
    Natural Killer T Cell Modulation of Cutaneous Wound Healing
    Role: Principal Investigator
    R33AI080528     (KOVACS, ELIZABETH J)Jul 1, 2008 - Jul 31, 2015
    NIH
    Inflammatory response after combined insult of radiation and burn injury
    Role: Principal Investigator
    R21AI080528     (KOVACS, ELIZABETH J)Jul 1, 2008 - Jul 31, 2010
    NIH
    Inflammatory response after combined insult of radiation and burn injury
    Role: Principal Investigator
    R13AA017084     (KOVACS, ELIZABETH J)Aug 5, 2007 - Jul 31, 2010
    NIH
    Alcohol &Immunology Research Interest Group (AIRIG) Meeting
    Role: Principal Investigator
    R13GM080954     (KOVACS, ELIZABETH J)Jun 1, 2007 - May 31, 2008
    NIH
    Alcohol and Trauma 2007
    Role: Principal Investigator
    R13AA016751     (KOVACS, ELIZABETH J)Sep 30, 2006 - Aug 31, 2007
    NIH
    Alcohol &Immunology Research Interest Group Meeting
    Role: Principal Investigator
    R13AA016057     (KOVACS, ELIZABETH J)Nov 10, 2005 - Nov 30, 2006
    NIH
    Alcohol &Immunology Research Interest Group Meeting
    Role: Principal Investigator
    R13AA015276     (KOVACS, ELIZABETH J)Jun 1, 2004 - May 31, 2005
    NIH
    Alcohol &Immunology Research Interest Group Meetings
    Role: Principal Investigator
    R01AI056108     (KOVACS, ELIZABETH J)Feb 15, 2004 - Jan 31, 2010
    NIH
    Natural Killer T cells and the immune response to injury
    Role: Principal Investigator
    T32AA013527     (CHOUDHRY, MASHKOOR A)Jul 1, 2002 - Jun 30, 2022
    NIH
    Training in Neuroimmunoendocrine Effects of Alcohol
    Role: Co-Principal Investigator
    R01GM115257     (KOVACS, ELIZABETH J.)Aug 1, 1999 - Mar 31, 2020
    NIH
    Ethanol Effects on Recovery after Injury
    Role: Principal Investigator
    R01AA012034     (KOVACS, ELIZABETH J)Aug 1, 1999 - Mar 31, 2015
    NIH
    Ethanol Effects on Recovery after Injury
    Role: Principal Investigator
    R03AG016067     (KOVACS, ELIZABETH J)Jul 1, 1998 - Jun 30, 2001
    NIH
    AGING, MACROPHAGE MEDIATORS, AND BURN TRAUMA
    Role: Principal Investigator
    R21AA011134     (KOVACS, ELIZABETH J)Sep 30, 1996 - Aug 31, 1999
    NIH
    ETHANOL EFFECTS ON RECOVERY FROM THERMAL INJURY
    Role: Principal Investigator
    R01GM055344     (KOVACS, ELIZABETH J)May 1, 1996 - Apr 30, 2000
    NIH
    ESTROGEN CONTROL OF CYTOKINE GENE EXPRESSION
    Role: Principal Investigator
    AG000279     (K Moreau)

    Aging and burn injury: Intestinal barrier dysfunction

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mohyuddin H, Laffon B, Teixeira JP, Costa S, Teixeira-Gomes A, P?saro E, Constantine N, Dagdag A, Ortmeyer HK, Tizenberg B, Afram L, Yen P, Marano C, Lowry CA, Hoisington AJ, RachBeisel JA, Valdiglesias V, Lema-Arranz C, Fern?ndez-Bert?lez N, Maseda A, Mill?n-Calenti JC, Kovacs EJ, Gostner JM, Fuchs D, Brenner LA, Lorenzo-L?pez L, Postolache TT. Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty. J Gerontol A Biol Sci Med Sci. 2024 Mar 01; 79(3). PMID: 37939652.
      View in: PubMed
    2. Hoisington LCAJ, Lowry CA, McDonald LT, Krefft SD, Rose CS, Kovacs EJ, Brenner LA. First Annual PACT Act Research Symposium on?Veterans Health: A Colorado PACT Act Collaboration (CoPAC) Initiative. Mil Med. 2024 Feb 27; 189(3-4):80-84. PMID: 37855327.
      View in: PubMed
    3. Anton PE, Rutt LN, Kaufman ML, Busquet N, Kovacs EJ, McCullough RL. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain Behav Immun. 2024 02; 116:303-316. PMID: 38151165.
      View in: PubMed
    4. Zillich L, Wagner J, McMahan RH, Park LM, Hodgkinson C, Kovacs EJ, Lohoff FW. Multi-omics analysis of alcohol effects on the liver in young and aged mice. Addict Biol. 2023 12; 28(12):e13342. PMID: 38017640.
      View in: PubMed
    5. Walrath T, Najarro KM, Giesy LE, Khair S, Frank DN, Robertson CE, Orlicky DJ, Quillinan N, Idrovo JP, McMahan RH, Kovacs EJ. REMOTE BURN INJURY IN AGED MICE INDUCES COLONIC LYMPHOID AGGREGATE EXPANSION AND DYSBIOSIS OF THE FECAL MICROBIOME WHICH CORRELATES WITH NEUROINFLAMMATION. Shock. 2023 10 01; 60(4):585-593. PMID: 37548929.
      View in: PubMed
    6. Khair S, Walrath TM, Curtis BJ, Orlicky DJ, McMahan RH, Kovacs EJ. Ethanol exacerbates pulmonary complications after burn injury in mice, regardless of frequency of ethanol exposures. Burns. 2023 12; 49(8):1935-1943. PMID: 37574341.
      View in: PubMed
    7. McNair BD, Polson SM, Shorthill SK, Yusifov A, Walker LA, Weiser-Evans MCM, Kovacs EJ, Bruns DR. Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK. Am J Physiol Heart Circ Physiol. 2023 08 01; 325(2):H278-H292. PMID: 37389952.
      View in: PubMed
    8. Malachowska B, Yang WL, Qualman A, Muro I, Boe DM, Lampe JN, Kovacs EJ, Idrovo JP. Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims. Commun Biol. 2023 06 02; 6(1):597. PMID: 37268765.
      View in: PubMed
    9. Muro I, Qualman AC, Kovacs EJ, Idrovo JP. Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL. J Surg Res. 2023 10; 290:147-155. PMID: 37267704.
      View in: PubMed
    10. Colbert JF, Kirsch JM, Erzen CL, Langou?t-Astri? CJ, Thompson GE, McMurtry SA, Kofonow JM, Robertson CE, Kovacs EJ, Sullivan RC, Hippensteel JA, Sawant NV, De Nisco NJ, McCollister BD, Schwartz RS, Horswill AR, Frank DN, Duerkop BA, Schmidt EP. Aging-Associated Augmentation of Gut Microbiome Virulence Capability Drives Sepsis Severity. mBio. 2023 06 27; 14(3):e0005223. PMID: 37102874.
      View in: PubMed
    11. McMahan RH, Anton P, Coleman LG, Cresci GAM, Crews FT, Crotty KM, Luck ME, Molina PE, Vachharajani V, Weinberg J, Yeligar SM, Choudhry MA, McCullough RL, Kovacs EJ. Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting. Alcohol. 2023 08; 110:57-63. PMID: 37061143.
      View in: PubMed
    12. Choy K, Dyamenahalli KU, Khair S, Colborn KL, Wiktor AJ, Idrovo JP, McMahan RH, Burnham EL, Kovacs EJ. Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function. Alcohol. 2023 06; 109:35-41. PMID: 36690221.
      View in: PubMed
    13. Colbert JF, Kirsch JM, Erzen CL, Langou?t-Astri? CJ, Thompson GE, McMurtry SA, Kofonow JM, Robertson CE, Kovacs EJ, Sullivan RC, Hippensteel JA, Sawant NV, De Nisco NJ, McCollister BD, Schwartz RS, Horswill AR, Frank DN, Duerkop BA, Schmidt EP. Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity. bioRxiv. 2023 Jan 11. PMID: 36711447.
      View in: PubMed
    14. Crotty K, Anton P, Coleman LG, Morris NL, Lewis SA, Samuelson DR, McMahan RH, Hartmann P, Kim A, Ratna A, Mandrekar P, Wyatt TA, Choudhry MA, Kovacs EJ, McCullough R, Yeligar SM. A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. Alcohol Clin Exp Res (Hoboken). 2023 01; 47(1):36-44. PMID: 36446606.
      View in: PubMed
    15. Walrath T, McMahan RH, Idrovo JP, Quillinan N, Kovacs EJ. Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice. Exp Gerontol. 2022 11; 169:111975. PMID: 36208823.
      View in: PubMed
    16. McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Kovacs EJ. Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. Alcohol. 2023 03; 107:136-143. PMID: 36150609.
      View in: PubMed
    17. Boe DM, Hulsebus HJ, Najarro KM, Mullen JE, Kim H, Tan AC, McMahan RH, Kovacs EJ. Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury. J Leukoc Biol. 2022 12; 112(6):1371-1386. PMID: 36120937.
      View in: PubMed
    18. Dyamenahalli K, Choy K, Frank DN, Najarro K, Boe D, Colborn KL, Idrovo JP, Wagner AL, Wiktor AJ, Afshar M, Burnham EL, McMahan RH, Kovacs EJ. Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients. J Burn Care Res. 2022 09 01; 43(5):1145-1153. PMID: 35020913.
      View in: PubMed
    19. McMahan RH, Boe DM, Walrath TM, Idrovo JP, Kovacs EJ. Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut. Adv Geriatr Med Res. 2022; 4(2). PMID: 35913894.
      View in: PubMed
    20. Khair S, Brenner LA, Koval M, Samuelson D, Cucinello-Regland JA, Anton P, Piano MR, Simon L, Crotty K, Sharieh F, Travers JB, Singh V, Cannon A, Kim A, McCullough RL, Yeligar SM, Wyatt TA, McMahan RH, Choudhry MA, Kovacs EJ. New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2022 09; 103:1-7. PMID: 35659577.
      View in: PubMed
    21. Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ. Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection. Front Immunol. 2022; 13:884719. PMID: 35603143.
      View in: PubMed
    22. McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Orlicky DJ, Kovacs EJ. Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice. Front Aging. 2022; 3. PMID: 35392033.
      View in: PubMed
    23. Najarro KM, Boe DM, Walrath TM, Mullen JE, Paul MT, Frankel JH, Hulsebus HJ, Idrovo JP, McMahan RH, Kovacs EJ. Advanced age exacerbates intestinal epithelial permeability after burn injury in mice. Exp Gerontol. 2022 02; 158:111654. PMID: 34915110.
      View in: PubMed
    24. McMahan RH, Najarro KM, Mullen JE, Paul MT, Orlicky DJ, Hulsebus HJ, Kovacs EJ. Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age. Immun Ageing. 2021 Oct 21; 18(1):39. PMID: 34674721.
      View in: PubMed
    25. McMahan RH, Najarro KM, Mullen JE, Paul MT, Orlicky DJ, Hulsebus HJ, Kovacs EJ. A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age. Immun Ageing. 2021 Sep 23; 18(1):37. PMID: 34556145.
      View in: PubMed
    26. Idrovo JP, Boe DM, Kaahui S, Walrath T, McMahan RH, Kovacs EJ. Advanced age heightens hepatic damage in a murine model of scald burn injury. J Trauma Acute Care Surg. 2021 04 01; 90(4):731-737. PMID: 33306599.
      View in: PubMed
    27. Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2022 12 01; 276(6):e961-e968. PMID: 33534233.
      View in: PubMed
    28. Walrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJ. Age-related changes in intestinal immunity and the microbiome. J Leukoc Biol. 2021 06; 109(6):1045-1061. PMID: 33020981.
      View in: PubMed
    29. Idrovo JP, Boe DM, Kaahui S, Yang WL, Kovacs EJ. Hepatic inflammation after burn injury is associated with necroptotic cell death signaling. J Trauma Acute Care Surg. 2020 10; 89(4):768-774. PMID: 33017135.
      View in: PubMed
    30. Moffatt LT, Madrzykowski D, Gibson ALF, Powell HM, Cancio LC, Wade CE, Choudhry MA, Kovacs EJ, Finnerty CC, Majetschak M, Shupp JW. Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings. J Burn Care Res. 2020 05 02; 41(3):604-611. PMID: 32011688.
      View in: PubMed
    31. McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJ. Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol. 2020 09; 87:89-95. PMID: 32353591.
      View in: PubMed
    32. Hua JT, Afshar M, Clark BJ, Kovacs EJ, Burnham EL. The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders. J Cannabis Res. 2020 Mar 02; 2(1):13. PMID: 33526125.
      View in: PubMed
    33. Wheatley EG, Curtis BJ, Hulsebus HJ, Boe DM, Najarro K, Ir D, Robertson CE, Choudhry MA, Frank DN, Kovacs EJ. Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice. Shock. 2020 01; 53(1):71-77. PMID: 30672882.
      View in: PubMed
    34. Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2019 12; 270(6):1186-1193. PMID: 29697443.
      View in: PubMed
    35. Idrovo JP, Shults JA, Curtis BJ, Chen MM, Kovacs EJ. Alcohol Intoxication and the Postburn Gastrointestinal Hormonal Response. J Burn Care Res. 2019 10 16; 40(6):785-791. PMID: 31102437.
      View in: PubMed
    36. Dyamenahalli K, Garg G, Shupp JW, Kuprys PV, Choudhry MA, Kovacs EJ. Inhalation Injury: Unmet Clinical Needs and Future Research. J Burn Care Res. 2019 08 14; 40(5):570-584. PMID: 31214710.
      View in: PubMed
    37. Lowery EM, Afshar M, West N, Kovacs EJ, Smith B, Joyce C. Self-reported alcohol use in the cystic fibrosis community. J Cyst Fibros. 2020 01; 19(1):84-90. PMID: 31303381.
      View in: PubMed
    38. Curtis BJ, Boe DM, Shults JA, Ramirez L, Kovacs EJ. Effects of Multiday Ethanol Intoxication on Postburn Inflammation, Lung Function, and Alveolar Macrophage Phenotype. Shock. 2019 05; 51(5):625-633. PMID: 29846360.
      View in: PubMed
    39. Rech MA, Mosier MJ, McConkey K, Zelisko S, Netzer G, Kovacs EJ, Afshar M. Outcomes in Burn-Injured Patients Who Develop Sepsis. J Burn Care Res. 2019 04 26; 40(3):269-273. PMID: 30805641.
      View in: PubMed
    40. Camargo Moreno M, Lewis JB, Kovacs EJ, Lowery EM. Lung allograft donors with excessive alcohol use have increased levels of human antimicrobial peptide LL-37. Alcohol. 2019 11; 80:109-117. PMID: 30419299.
      View in: PubMed
    41. Curtis BJ, Shults JA, Boe DM, Ramirez L, Kovacs EJ. Mesenchymal stem cell treatment attenuates liver and lung inflammation after ethanol intoxication and burn injury. Alcohol. 2019 11; 80:139-148. PMID: 30217504.
      View in: PubMed
    42. Kuprys PV, Tsukamoto H, Gao B, Jia L, McGowan J, Coopersmith CM, Moreno MC, Hulsebus H, Meena AS, Souza-Smith FM, Roper P, Foster MT, Raju SV, Marshall SA, Fujita M, Curtis BJ, Wyatt TA, Mandrekar P, Kovacs EJ, Choudhry MA. Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2019 06; 77:11-18. PMID: 30763905.
      View in: PubMed
    43. Afshar M, Burnham EL, Joyce C, Kovacs EJ, Lowery EM. Optimal Cut-Points for Phosphatidylethanol Vary by Clinical Setting: Response to Nguyen and Seth's (2018) Letter to the Editor. Alcohol Clin Exp Res. 2018 10; 42(10):2064-2065. PMID: 30059162.
      View in: PubMed
    44. Lowery EM, Yong M, Cohen A, Joyce C, Kovacs EJ. Recent alcohol use prolongs hospital length of stay following lung transplant. Clin Transplant. 2018 06; 32(6):e13250. PMID: 29620796.
      View in: PubMed
    45. Lowery EM, Walsh M, Yong M, Kovacs EJ, Joyce C, Afshar M. Use of alcohol biomarkers to identify alcohol misuse in organ donors. Alcohol. 2018 12; 73:67-72. PMID: 30312857.
      View in: PubMed
    46. Hulsebus HJ, Curtis BJ, Molina PE, Afshar M, Boule LA, Morris N, Keshavarzian A, Kolls JK, Yeligar SM, Price ME, Wyatt TA, Choudhry MA, Kovacs EJ. Summary of the 2017 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 06; 69:51-56. PMID: 29654985.
      View in: PubMed
    47. Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2018 05; 105:78-86. PMID: 29080833.
      View in: PubMed
    48. Budinger GRS, Kohanski RA, Gan W, Kobor MS, Amaral LA, Armanios M, Kelsey KT, Pardo A, Tuder R, Macian F, Chandel N, Vaughan D, Rojas M, Mora AL, Kovacs E, Duncan SR, Finkel T, Choi A, Eickelberg O, Chen D, Agusti A, Selman M, Balch WE, Busse P, Lin A, Morimoto R, Sznajder JI, Thannickal VJ. The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1492-1500. PMID: 28498894.
      View in: PubMed
    49. Boule LA, Ju C, Agudelo M, Parira T, Cannon A, Davis B, Eby J, Cresci G, Samuelson DR, Shukla P, Alrefai WA, Sureshchandra S, Pandey SC, Schnabl B, Curtis BJ, Wyatt TA, Choudhry MA, Kovacs EJ. Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 02; 66:35-43. PMID: 29127885.
      View in: PubMed
    50. Afshar M, Burnham EL, Joyce C, Clark BJ, Yong M, Gaydos J, Cooper RS, Smith GS, Kovacs EJ, Lowery EM. Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcohol Clin Exp Res. 2017 Oct; 41(10):1745-1753. PMID: 28792620.
      View in: PubMed
    51. Afshar M, Netzer G, Mosier MJ, Cooper RS, Adams W, Burnham EL, Kovacs EJ, Durazo-Arvizu R, Kliethermes S. The Contributing Risk of Tobacco Use for ARDS Development in Burn-Injured Adults With Inhalation Injury. Respir Care. 2017 Nov; 62(11):1456-1465. PMID: 28900039.
      View in: PubMed
    52. Rech MA, Mosier MJ, Zelisko S, Netzer G, Kovacs EJ, Afshar M. Comparison of Automated Methods Versus the American Burn Association Sepsis Definition to Identify Sepsis and Sepsis With Organ Dysfunction/Septic Shock in Burn-Injured Adults. J Burn Care Res. 2017 Sep/Oct; 38(5):312-318. PMID: 28230556.
      View in: PubMed
    53. Kovacs EJ, Boe DM, Boule LA, Curtis BJ. Inflammaging and the Lung. Clin Geriatr Med. 2017 11; 33(4):459-471. PMID: 28991644.
      View in: PubMed
    54. Boule LA, Kovacs EJ. Alcohol, aging, and innate immunity. J Leukoc Biol. 2017 07; 102(1):41-55. PMID: 28522597.
      View in: PubMed
    55. Chen MM, Carter SR, Curtis BJ, O'Halloran EB, Gamelli RL, Kovacs EJ. Alcohol Modulation of the Postburn Hepatic Response. J Burn Care Res. 2017 Jan/Feb; 38(1):e144-e157. PMID: 26284631.
      View in: PubMed
    56. Boe DM, Boule LA, Kovacs EJ. Innate immune responses in the ageing lung. Clin Exp Immunol. 2017 Jan; 187(1):16-25. PMID: 27711979.
      View in: PubMed
    57. Skloot GS, Busse PJ, Braman SS, Kovacs EJ, Dixon AE, Vaz Fragoso CA, Scichilone N, Prakash YS, Pabelick CM, Mathur SK, Hanania NA, Moore WC, Gibson PG, Zieman S, Ragless BB. An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly. Ann Am Thorac Soc. 2016 11; 13(11):2064-2077. PMID: 27831798.
      View in: PubMed
    58. Thompson MG, Navarro F, Chitsike L, Ramirez L, Kovacs EJ, Watkins SK. Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function. Alcohol. 2016 12; 57:1-8. PMID: 27916138.
      View in: PubMed
    59. Chen MM, O'Halloran EB, Shults JA, Kovacs EJ. Kupffer Cell p38 Mitogen-Activated Protein Kinase Signaling Drives Postburn Hepatic Damage and Pulmonary Inflammation When Alcohol Intoxication Precedes Burn Injury. Crit Care Med. 2016 10; 44(10):e973-9. PMID: 27322363.
      View in: PubMed
    60. Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. Alcohol and lung injury and immunity. Alcohol. 2016 09; 55:51-59. PMID: 27788778.
      View in: PubMed
    61. Curtis BJ, Shults JA, Ramirez L, Kovacs EJ. Remote Burn Injury Increases Pulmonary Histone Deacetylase 1 and Reduces Histone Acetylation. J Burn Care Res. 2016 Sep-Oct; 37(5):321-7. PMID: 26629657.
      View in: PubMed
    62. Plackett TP, Deburghraeve CR, Palmer JL, Gamelli RL, Kovacs EJ. Effects of Estrogen on Bacterial Clearance and Neutrophil Response After Combined Burn Injury and Wound Infection. J Burn Care Res. 2016 Sep-Oct; 37(5):328-33. PMID: 27058581.
      View in: PubMed
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    73. Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, DiPietro L, Falanga V, Fife C, Gardner S, Grice E, Harmon J, Hazzard WR, High KP, Houghton P, Jacobson N, Kirsner RS, Kovacs EJ, Margolis D, McFarland Horne F, Reed MJ, Sullivan DH, Thom S, Tomic-Canic M, Walston J, Whitney JA, Williams J, Zieman S, Schmader K. Chronic wound repair and healing in older adults: current status and future research. J Am Geriatr Soc. 2015 Mar; 63(3):427-38. PMID: 25753048.
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    76. Brubaker AL, Carter SR, Kovacs EJ. Experimental Approaches to Tissue Injury and Repair in Advanced Age. Methods Mol Biol. 2015; 1343:35-51. PMID: 26420707.
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    77. Chen MM, O'Halloran EB, Ippolito JA, Choudhry MA, Kovacs EJ. Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin. Shock. 2015 Jan; 43(1):80-4. PMID: 25243425.
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    79. Chen MM, Zahs A, Chang SL, Kovacs EJ. Street smarts of science for students. Nat Immunol. 2014 Nov; 15(11):997-9. PMID: 25329178.
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    88. Chen MM, Palmer JL, Plackett TP, Deburghgraeve CR, Kovacs EJ. Age-related differences in the neutrophil response to pulmonary pseudomonas infection. Exp Gerontol. 2014 Jun; 54:42-6. PMID: 24398045.
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    90. Lowery EM, Brubaker AL, Kuhlmann E, Kovacs EJ. The aging lung. Clin Interv Aging. 2013; 8:1489-96. PMID: 24235821.
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    92. Carter SR, Zahs A, Palmer JL, Wang L, Ramirez L, Gamelli RL, Kovacs EJ. Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury. Shock. 2013 Oct; 40(4):281-9. PMID: 24045418.
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    93. Brubaker AL, Kovacs EJ. G-CSF enhances resolution of Staphylococcus aureus wound infection in an age-dependent manner. Shock. 2013 Oct; 40(4):327-33. PMID: 23856924.
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    96. Davis CS, Mendez BM, Flint DV, Pelletiere K, Lowery E, Ramirez L, Love RB, Kovacs EJ, Fisichella PM. Pepsin concentrations are elevated in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis after lung transplantation. J Surg Res. 2013 Dec; 185(2):e101-8. PMID: 23845868.
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    102. Brubaker AL, Rendon JL, Ramirez L, Choudhry MA, Kovacs EJ. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol. 2013 Feb 15; 190(4):1746-57. PMID: 23319733.
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    103. Davis CS, Esposito TJ, Palladino-Davis AG, Rychlik K, Schermer CR, Gamelli RL, Kovacs EJ. Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysis. J Burn Care Res. 2013 Jan-Feb; 34(1):120-6. PMID: 23079566.
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    105. Sakai LM, Esposito TJ, Ton-That HH, Omi EC, Kovacs EJ, Schermer CR. Comparison of Objective Screening and Self-Report for Alcohol and Drug Use in Traumatically Injured Patients. Alcohol Treat Q. 2012 Oct 01; 30(4):433-442. PMID: 26752806.
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    106. Biju PG, Garg S, Wang W, Choudhry MA, Kovacs EJ, Fink LM, Hauer-Jensen M. Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice. Shock. 2012 Aug; 38(2):170-6. PMID: 22576002.
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    109. Fisichella PM, Davis CS, Lowery E, Pittman M, Gagermeier J, Love RB, Kovacs EJ. Pulmonary immune changes early after laparoscopic antireflux surgery in lung transplant patients with gastroesophageal reflux disease. J Surg Res. 2012 Oct; 177(2):e65-73. PMID: 22537841.
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    116. Davis CS, Albright JM, Carter SR, Ramirez L, Kim H, Gamelli RL, Kovacs EJ. Early pulmonary immune hyporesponsiveness is associated with mortality after burn and smoke inhalation injury. J Burn Care Res. 2012 Jan-Feb; 33(1):26-35. PMID: 21979852.
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    122. Zahs A, Cook RT, Waldschimdt TJ, Choudhry MA, Kovacs EJ, Bird MD. Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting. Alcohol. 2012 Mar; 46(2):147-53. PMID: 21917410.
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    139. Davis CS, Gagermeier J, Dilling D, Alex C, Lowery E, Kovacs EJ, Love RB, Fisichella PM. A review of the potential applications and controversies of non-invasive testing for biomarkers of aspiration in the lung transplant population. Clin Transplant. 2010 May-Jun; 24(3):E54-61. PMID: 20331688.
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    147. Gomez CR, Nomellini V, Baila H, Oshima K, Kovacs EJ. Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration. Shock. 2009 Feb; 31(2):178-84. PMID: 18636046.
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    150. Silver GM, Albright JM, Schermer CR, Halerz M, Conrad P, Ackerman PD, Lau L, Emanuele MA, Kovacs EJ, Gamelli RL. Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury. J Burn Care Res. 2008 Sep-Oct; 29(5):784-9. PMID: 18695611.
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    152. Gomez CR, Nomellini V, Faunce DE, Kovacs EJ. Innate immunity and aging. Exp Gerontol. 2008 Aug; 43(8):718-28. PMID: 18586079.
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    153. Radek KA, Kovacs EJ, Gallo RL, DiPietro LA. Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol. 2008 Jul; 295(1):H174-84. PMID: 18469146.
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    155. Goral J, Karavitis J, Kovacs EJ. Exposure-dependent effects of ethanol on the innate immune system. Alcohol. 2008 Jun; 42(4):237-47. PMID: 18411007.
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    156. Bird MD, Kovacs EJ. Organ-specific inflammation following acute ethanol and burn injury. J Leukoc Biol. 2008 Sep; 84(3):607-13. PMID: 18362209.
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    157. Nomellini V, Faunce DE, Gomez CR, Kovacs EJ. An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J Leukoc Biol. 2008 Jun; 83(6):1493-501. PMID: 18319289.
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    158. Murdoch EL, Brown HG, Gamelli RL, Kovacs EJ. Effects of ethanol on pulmonary inflammation in postburn intratracheal infection. J Burn Care Res. 2008 Mar-Apr; 29(2):323-30. PMID: 18354289.
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    159. Waldschmidt TJ, Cook RT, Kovacs EJ. Alcohol and inflammation and immune responses: summary of the 2006 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2008 Mar; 42(2):137-42. PMID: 18358993.
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    160. Bird MD, Karavitis J, Kovacs EJ. Sex differences and estrogen modulation of the cellular immune response after injury. Cell Immunol. 2008 Mar-Apr; 252(1-2):57-67. PMID: 18294625.
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    161. Plackett TP, Kovacs EJ. Acute models of ethanol exposure to mice. Methods Mol Biol. 2008; 447:3-9. PMID: 18369907.
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    162. Nomellini V, Gomez CR, Kovacs EJ. Aging and impairment of innate immunity. Contrib Microbiol. 2008; 15:188-205. PMID: 18511862.
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    163. Kovacs E, Meichsner-Frauli M, Ludwig H. Interleukin-2 receptor positive cells in human decidua during the first trimester of pregnancy and their association with macrophages. Arch Gynecol Obstet. 1992; 251(2):93-100. PMID: 1533757.
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    164. Kelley J, Kovacs EJ, Nicholson K, Fabisiak JP. Transforming growth factor-beta production by lung macrophages and fibroblasts. Chest. 1991 Mar; 99(3 Suppl):85S-86S. PMID: 1705204.
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    165. Kovacs E, Weber W, M?ller H. Age-related variation in the DNA-repair synthesis after UV-C irradiation in unstimulated lymphocytes of healthy blood donors. Mutat Res. 1984 May-Jun; 131(5-6):231-7. PMID: 6738567.
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