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Kristofer S Fritz

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3398

    Collapse Research 
    Collapse research activities and funding
    R41AA030517     (FRITZ, KRISTOFER S.)Apr 1, 2023 - Mar 31, 2024
    NIH
    Novel Treatment for Alcohol-associated Liver Disease
    Role: Principal Investigator
    R01AA030024     (FRITZ, KRISTOFER S.)Feb 25, 2023 - Jan 31, 2028
    NIH
    Alcohol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control
    Role: Principal Investigator
    R21AA029218     (FRITZ, KRISTOFER S.)Sep 25, 2021 - Aug 31, 2023
    NIH
    Mechanisms of Alcohol Toxicity and Kidney Damage
    Role: Principal Investigator
    R21AA026928     (FRITZ, KRISTOFER S.)Sep 5, 2018 - Aug 31, 2021
    NIH
    Ethanol Metabolism Disrupts Hepatic Thiol Redox Signaling and Control
    Role: Principal Investigator
    R01DK109964     (ROSS, DAVID)Apr 1, 2017 - Mar 31, 2022
    NIH
    Regulation of insulin signaling and sensitivity by the xenobiotic metabolizing enzyme NQO1
    Role: Co-Principal Investigator
    R01AA022146     (HIRSCHEY, MATTHEW D)Aug 5, 2013 - Jun 30, 2018
    NIH
    Ethanol-induced Protein Acylation Regulates Metabolism
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Harris PS, McGinnis CD, Michel CR, Marentette JO, Reisdorph R, Roede JR, Fritz KS. Click chemistry-based thiol redox proteomics reveals significant cysteine reduction induced by chronic ethanol consumption. Redox Biol. 2023 08; 64:102792. PMID: 37390786.
      View in: PubMed
    2. Pearson-Smith JN, Fulton R, Huynh CQ, Figueroa AG, Huynh GB, Liang LP, Gano LB, Michel CR, Reisdorph N, Reisdorph R, Fritz KS, Verdin E, Patel M. Neuronal SIRT3 Deletion Predisposes to Female-Specific Alterations in Cellular Metabolism, Memory, and Network Excitability. J Neurosci. 2023 03 08; 43(10):1845-1857. PMID: 36759193.
      View in: PubMed
    3. Siegel D, Harris PS, Michel CR, de Cabo R, Fritz KS, Ross D. Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1. Front Pharmacol. 2022; 13:1015642. PMID: 36408211.
      View in: PubMed
    4. McGinnis CD, Graham BIM, Harris PS, Fritz KS. Advancing proteomics and machine learning in the clinic: an editorial on "Noninvasive proteomic biomarkers for alcohol-related liver disease". Hepatobiliary Surg Nutr. 2022 Oct; 11(5):762-765. PMID: 36268253.
      View in: PubMed
    5. McGinnis CD, Jennings EQ, Harris PS, Galligan JJ, Fritz KS. Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction. Cells. 2022 06 28; 11(13). PMID: 35805129.
      View in: PubMed
    6. Elajaili H, Hernandez-Lagunas L, Harris P, Sparagna GC, Jonscher R, Ohlstrom D, Sucharov CC, Bowler RP, Suliman H, Fritz KS, Roede JR, Nozik ES. Extracellular superoxide dismutase (EC-SOD) R213G variant reduces mitochondrial ROS and preserves mitochondrial function in bleomycin-induced lung injury: EC-SOD R213G variant and intracellular redox regulation. Adv Redox Res. 2022 Jul; 5. PMID: 38273965.
      View in: PubMed
    7. Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KS. Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker. Alcohol. 2022 03; 99:35-48. PMID: 34923085.
      View in: PubMed
    8. Jennings EQ, Fritz KS, Galligan JJ. Biochemical genesis of enzymatic and non-enzymatic post-translational modifications. Mol Aspects Med. 2022 08; 86:101053. PMID: 34838336.
      View in: PubMed
    9. Siegel D, Bersie S, Harris P, Di Francesco A, Armstrong M, Reisdorph N, Bernier M, de Cabo R, Fritz K, Ross D. A redox-mediated conformational change in NQO1 controls binding to microtubules and a-tubulin acetylation. Redox Biol. 2021 02; 39:101840. PMID: 33360352.
      View in: PubMed
    10. Di Francesco A, Choi Y, Bernier M, Zhang Y, Diaz-Ruiz A, Aon MA, Kalafut K, Ehrlich MR, Murt K, Ali A, Pearson KJ, Levan S, Preston JD, Martin-Montalvo A, Martindale JL, Abdelmohsen K, Michel CR, Willmes DM, Henke C, Navas P, Villalba JM, Siegel D, Gorospe M, Fritz K, Biswal S, Ross D, de Cabo R. NQO1 protects obese mice through improvements in glucose and lipid metabolism. NPJ Aging Mech Dis. 2020 Nov 19; 6(1):13. PMID: 33298924.
      View in: PubMed
    11. Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC. Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. J Mol Cell Cardiol. 2020 02; 139:135-147. PMID: 31981571.
      View in: PubMed
    12. Nam MH, Smith AJO, Pantcheva MB, Park KU, Brzezinski JA, Galligan JJ, Fritz K, Wormstone IM, Nagaraj RH. Aspirin inhibits TGF?2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3. Biochem J. 2020 01 17; 477(1):75-97. PMID: 31815277.
      View in: PubMed
    13. Goswami DG, Kant R, Ammar DA, Agarwal C, Gomez J, Agarwal R, Saba LM, Fritz KS, Tewari-Singh N. Toxic consequences and oxidative protein carbonylation from chloropicrin exposure in human corneal epithelial cells. Toxicol Lett. 2020 Apr 01; 322:1-11. PMID: 31884112.
      View in: PubMed
    14. Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 2020 01; 138:304-317. PMID: 31836543.
      View in: PubMed
    15. Assiri MA, Ali HR, Marentette JO, Yun Y, Liu J, Hirschey MD, Saba LM, Harris PS, Fritz KS. Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease. Hum Genomics. 2019 12 10; 13(1):65. PMID: 31823815.
      View in: PubMed
    16. Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR. SNARE proteins rescue impaired autophagic flux in Down syndrome. PLoS One. 2019; 14(11):e0223254. PMID: 31714914.
      View in: PubMed
    17. Nahomi RB, Nandi SK, Rakete S, Michel C, Fritz KS, Nagaraj RH. Lysine malonylation and propionylation are prevalent in human lens proteins. Exp Eye Res. 2020 01; 190:107864. PMID: 31678036.
      View in: PubMed
    18. Marentette JO, Wang M, Michel CR, Powell R, Zhang X, Reisdorph N, Fritz KS, Ju C. Multi-omics Analysis of Liver Infiltrating Macrophages Following Ethanol Consumption. Sci Rep. 2019 05 23; 9(1):7776. PMID: 31123328.
      View in: PubMed
    19. Nandi SK, Nahomi RB, Harris PS, Michel CR, Fritz KS, Nagaraj RH. The absence of SIRT3 and SIRT5 promotes the acetylation of lens proteins and improves the chaperone activity of a-crystallin in mouse lenses. Exp Eye Res. 2019 05; 182:1-9. PMID: 30849386.
      View in: PubMed
    20. Nandi SK, Rakete S, Nahomi RB, Michel C, Dunbar A, Fritz KS, Nagaraj RH. Succinylation Is a Gain-of-Function Modification in Human Lens aB-Crystallin. Biochemistry. 2019 03 05; 58(9):1260-1274. PMID: 30758948.
      View in: PubMed
    21. Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS. Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism. J Proteome Res. 2019 04 05; 18(4):1513-1531. PMID: 30644754.
      View in: PubMed
    22. Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep. 2018 12 03; 8(1):17547. PMID: 30510203.
      View in: PubMed
    23. Ali H, Assiri MA, Shearn CT, Fritz KS. Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. Curr Opin Toxicol. 2019 Feb; 13:110-117. PMID: 31263795.
      View in: PubMed
    24. Gomez JD, Ridgeway ME, Park MA, Fritz KS. Utilizing Ion Mobility to Identify Isobaric Post-Translational Modifications: Resolving Acrolein and Propionyl Lysine Adducts by TIMS Mass Spectrometry. Int J Ion Mobil Spectrom. 2018 Sep; 21(3):65-69. PMID: 30369833.
      View in: PubMed
    25. Gano LB, Liang LP, Ryan K, Michel CR, Gomez J, Vassilopoulos A, Reisdorph N, Fritz KS, Patel M. Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med. 2018 08 01; 123:116-124. PMID: 29778462.
      View in: PubMed
    26. Reisdorph NA, Michel C, Fritz K, Reisdorph R. Application of Proteomics in Lung Research. Methods Mol Biol. 2018; 1809:237-262. PMID: 29987793.
      View in: PubMed
    27. Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res. 2017 Oct; 41(10):1705-1714. PMID: 28804911.
      View in: PubMed
    28. Raghavendra AJ, Fritz K, Fu S, Brown JM, Podila R, Shannahan JH. Variations in biocorona formation related to defects in the structure of single walled carbon nanotubes and the hyperlipidemic disease state. Sci Rep. 2017 08 16; 7(1):8382. PMID: 28814800.
      View in: PubMed
    29. Harris PS, Gomez JD, Backos DS, Fritz KS. Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2. Chem Res Toxicol. 2017 03 20; 30(3):785-793. PMID: 28248093.
      View in: PubMed
    30. Galligan JJ, Kingsley PJ, Wauchope OR, Mitchener MM, Camarillo JM, Wepy JA, Harris PS, Fritz KS, Marnett LJ. Quantitative Analysis and Discovery of Lysine and Arginine Modifications. Anal Chem. 2017 01 17; 89(2):1299-1306. PMID: 27982582.
      View in: PubMed
    31. Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med. 2017 02; 103:48-56. PMID: 27939935.
      View in: PubMed
    32. Heit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V. Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS. Alcohol Clin Exp Res. 2016 09; 40(9):1825-31. PMID: 27501276.
      View in: PubMed
    33. Shannahan JH, Fritz KS, Raghavendra AJ, Podila R, Persaud I, Brown JM. From the Cover: Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences. Toxicol Sci. 2016 08; 152(2):406-16. PMID: 27255384.
      View in: PubMed
    34. Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr; 7:68-77. PMID: 26654979.
      View in: PubMed
    35. Coughlan C, Walker DI, Lohr KM, Richardson JR, Saba LM, Caudle WM, Fritz KS, Roede JR. Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice. Parkinsons Dis. 2015; 2015:812532. PMID: 26345149.
      View in: PubMed
    36. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Redox Biol. 2015 Dec; 6:33-40. PMID: 26177469.
      View in: PubMed
    37. Blakeslee WW, Wysoczynski CL, Fritz KS, Nyborg JK, Churchill ME, McKinsey TA. Class I HDAC inhibition stimulates cardiac protein SUMOylation through a post-translational mechanism. Cell Signal. 2014 Dec; 26(12):2912-20. PMID: 25220405.
      View in: PubMed
    38. Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR. Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function. Free Radic Biol Med. 2014 Aug; 73:411-20. PMID: 24924946.
      View in: PubMed
    39. Poerschke RL, Fritz KS, Franklin CC. Methods to detect protein glutathionylation. Curr Protoc Toxicol. 2013 Sep 23; 57:6.17.1-6.17.18. PMID: 24510510.
      View in: PubMed
    40. Fritz KS, Green MF, Petersen DR, Hirschey MD. Ethanol metabolism modifies hepatic protein acylation in mice. PLoS One. 2013; 8(9):e75868. PMID: 24073283.
      View in: PubMed
    41. Backos DS, Fritz KS, McArthur DG, Kepa JK, Donson AM, Petersen DR, Foreman NK, Franklin CC, Reigan P. Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma. Neurochem Res. 2013 Sep; 38(9):1838-49. PMID: 23743623.
      View in: PubMed
    42. Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. J Lipid Res. 2013 May; 54(5):1335-45. PMID: 23359610.
      View in: PubMed
    43. Fritz KS. Chemical acetylation and deacetylation. Methods Mol Biol. 2013; 1077:191-201. PMID: 24014408.
      View in: PubMed
    44. Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. J Toxicol. 2012; 2012:207594. PMID: 22829816.
      View in: PubMed
    45. Fritz KS, Petersen DR. An overview of the chemistry and biology of reactive aldehydes. Free Radic Biol Med. 2013 Jun; 59:85-91. PMID: 22750507.
      View in: PubMed
    46. Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. PLoS One. 2012; 7(6):e38459. PMID: 22701647.
      View in: PubMed
    47. Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol. 2012 May 21; 25(5):1012-21. PMID: 22502949.
      View in: PubMed
    48. Fritz KS, Kellersberger KA, Gomez JD, Petersen DR. 4-HNE adduct stability characterized by collision-induced dissociation and electron transfer dissociation mass spectrometry. Chem Res Toxicol. 2012 Apr 16; 25(4):965-70. PMID: 22404378.
      View in: PubMed
    49. Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR. Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res. 2012 Mar 02; 11(3):1633-43. PMID: 22309199.
      View in: PubMed
    50. Fritz KS, Petersen DR. Exploring the biology of lipid peroxidation-derived protein carbonylation. Chem Res Toxicol. 2011 Sep 19; 24(9):1411-9. PMID: 21812433.
      View in: PubMed
    51. Vassilopoulos A, Fritz KS, Petersen DR, Gius D. The human sirtuin family: evolutionary divergences and functions. Hum Genomics. 2011 Jul; 5(5):485-96. PMID: 21807603.
      View in: PubMed
    52. Shearn CT, Fritz KS, Thompson JA. Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene. Chem Biol Interact. 2011 Jul 15; 192(3):278-86. PMID: 21536018.
      View in: PubMed
    53. Shearn CT, Fritz KS, Reigan P, Petersen DR. Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells. Biochemistry. 2011 May 17; 50(19):3984-96. PMID: 21438592.
      View in: PubMed
    54. Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62. PMID: 21449565.
      View in: PubMed
    55. Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N, Petersen DR. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. Mol Pharmacol. 2011 Jun; 79(6):941-52. PMID: 21415306.
      View in: PubMed
    56. Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47. PMID: 21319786.
      View in: PubMed
    57. Backos DS, Fritz KS, Roede JR, Petersen DR, Franklin CC. Posttranslational modification and regulation of glutamate-cysteine ligase by the a,?-unsaturated aldehyde 4-hydroxy-2-nonenal. Free Radic Biol Med. 2011 Jan 01; 50(1):14-26. PMID: 20970495.
      View in: PubMed
    58. Shearn CT, Fritz KS, Meier BW, Kirichenko OV, Thompson JA. Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro. Chem Res Toxicol. 2008 Aug; 21(8):1631-41. PMID: 18597497.
      View in: PubMed
    59. Fritz KS, McKean AJ, Nelson JC, Wilcox RB. Analog-based free testosterone test results linked to total testosterone concentrations, not free testosterone concentrations. Clin Chem. 2008 Mar; 54(3):512-6. PMID: 18171714.
      View in: PubMed
    60. Fritz KS, Weiss RM, Nelson JC, Wilcox RB. Unequal concentrations of free T3 and free T4 after ultrafiltration. Clin Chem. 2007 Jul; 53(7):1384-5. PMID: 17582152.
      View in: PubMed
    61. Fritz KS, Wilcox RB, Nelson JC. Quantifying spurious free T4 results attributable to thyroxine-binding proteins in serum dialysates and ultrafiltrates. Clin Chem. 2007 May; 53(5):985-8. PMID: 17395710.
      View in: PubMed
    62. Fritz KS, Wilcox RB, Nelson JC. A direct free thyroxine (T4) immunoassay with the characteristics of a total T4 immunoassay. Clin Chem. 2007 May; 53(5):911-5. PMID: 17363415.
      View in: PubMed
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