 Lysosomes
"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D008247
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| MeSH Number(s) |
A11.284.430.214.190.875.190.550
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2001 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 2 | 2 | 4 | | 2010 | 0 | 2 | 2 | | 2011 | 1 | 2 | 3 | | 2012 | 2 | 2 | 4 | | 2014 | 1 | 3 | 4 | | 2015 | 3 | 4 | 7 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 3 | 3 | | 2018 | 4 | 1 | 5 | | 2019 | 2 | 6 | 8 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 5 | 6 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 1 | 2 | | 2024 | 1 | 1 | 2 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, Kedziora KM, Stolz DB, Wallace CT, Yu-Wei C, Franks J, Bose D, Shang P, Ambrosino HM, Dutton JR, Geng Z, Montford J, Ryu J, Rajasundaram D, Hose S, Sahel JA, Puertollano R, Finkel T, Zigler JS, Sergeev Y, Watkins SC, Goetzman ES, Ferrington DA, Flores-Bellver M, Kaarniranta K, Sodhi A, Bharti K, Handa JT, Sinha D. The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD. Nat Commun. 2024 Jul 21; 15(1):6150.
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Mendoza AD, Dietrich N, Tan CH, Herrera D, Kasiah J, Payne Z, Cubillas C, Schneider DL, Kornfeld K. Lysosome-related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis. Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7):e2307143121.
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Hoffman HK, Prekeris R. HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells. J Cell Sci. 2024 03 01; 137(5).
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Haddad G, Dylewski J, Evans R, Lewis L, Blaine J. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. PLoS One. 2023; 18(4):e0284636.
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Hoffman HK, Aguilar RS, Clark AR, Groves NS, Pezeshkian N, Bruns MM, van Engelenburg SB. Endocytosed HIV-1 Envelope Glycoprotein Traffics to Rab14+ Late Endosomes and Lysosomes to Regulate Surface Levels in T-Cell Lines. J Virol. 2022 07 27; 96(14):e0076722.
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Mondal K, Porter H, Cole J, Pandya HK, Basu SK, Khanam S, Chiu CY, Shah V, Stephenson DJ, Chalfant CE, Mandal N. Hydroxychloroquine Causes Early Inner Retinal Toxicity and Affects Autophagosome-Lysosomal Pathway and Sphingolipid Metabolism in the Retina. Mol Neurobiol. 2022 Jun; 59(6):3873-3887.
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Parashar S, Chidambaram R, Chen S, Liem CR, Griffis E, Lambert GG, Shaner NC, Wortham M, Hay JC, Ferro-Novick S. Endoplasmic reticulum tubules limit the size of misfolded protein condensates. Elife. 2021 09 01; 10.
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Towers CG, Wodetzki DK, Thorburn J, Smith KR, Caino MC, Thorburn A. Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy. Dev Cell. 2021 07 26; 56(14):2029-2042.e5.
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Kleele T, Rey T, Winter J, Zaganelli S, Mahecic D, Perreten Lambert H, Ruberto FP, Nemir M, Wai T, Pedrazzini T, Manley S. Distinct fission signatures predict mitochondrial degradation or biogenesis. Nature. 2021 05; 593(7859):435-439.
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Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 03 05; 12(3):248.
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