 Tumor Necrosis Factor-alpha
"Tumor Necrosis Factor-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
| Descriptor ID |
D014409
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| MeSH Number(s) |
D12.644.276.374.500.800 D12.644.276.374.750.626 D12.776.124.900 D12.776.395.930 D12.776.467.374.500.800 D12.776.467.374.750.626 D23.529.374.500.800 D23.529.374.750.626
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| Concept/Terms |
Tumor Necrosis Factor-alpha- Tumor Necrosis Factor-alpha
- Tumor Necrosis Factor alpha
- Cachectin
- Cachectin-Tumor Necrosis Factor
- Cachectin Tumor Necrosis Factor
- Tumor Necrosis Factor Ligand Superfamily Member 2
- Tumor Necrosis Factor
- TNF Superfamily, Member 2
- TNFalpha
- TNF-alpha
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor-alpha".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor-alpha".
This graph shows the total number of publications written about "Tumor Necrosis Factor-alpha" by people in this website by year, and whether "Tumor Necrosis Factor-alpha" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 13 | 12 | 25 | | 1996 | 13 | 8 | 21 | | 1997 | 18 | 14 | 32 | | 1998 | 15 | 15 | 30 | | 1999 | 14 | 15 | 29 | | 2000 | 9 | 19 | 28 | | 2001 | 16 | 18 | 34 | | 2002 | 7 | 27 | 34 | | 2003 | 18 | 17 | 35 | | 2004 | 17 | 25 | 42 | | 2005 | 15 | 22 | 37 | | 2006 | 13 | 21 | 34 | | 2007 | 11 | 18 | 29 | | 2008 | 10 | 17 | 27 | | 2009 | 14 | 19 | 33 | | 2010 | 7 | 7 | 14 | | 2011 | 10 | 19 | 29 | | 2012 | 6 | 16 | 22 | | 2013 | 9 | 16 | 25 | | 2014 | 13 | 27 | 40 | | 2015 | 6 | 20 | 26 | | 2016 | 8 | 13 | 21 | | 2017 | 7 | 8 | 15 | | 2018 | 4 | 15 | 19 | | 2019 | 8 | 9 | 17 | | 2020 | 5 | 18 | 23 | | 2021 | 4 | 17 | 21 | | 2022 | 6 | 14 | 20 | | 2023 | 0 | 12 | 12 | | 2024 | 4 | 12 | 16 | | 2025 | 3 | 3 | 6 |
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Below are the most recent publications written about "Tumor Necrosis Factor-alpha" by people in Profiles.
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Sripada A, Verma D, Varma R, Sirohi K, Kwiat C, Pathria M, Verma M, Sahu A, Guntur V, Manka L, Vestal B, Moore C, Martin RJ, Gorska MM, Cambier J, Getahun A, Alam R. Allergens abrogate antiinflammatory DNA effects and unmask macrophage-driven neutrophilic asthma via ILC2/STING/TNF-a signaling. J Clin Invest. 2025 Aug 15; 135(16).
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Rojas-Sanchez G, Calzada-Martinez J, McMahon B, Petrey AC, Dveksler G, Espino-Solis GP, Esparza O, Hernandez G, Le D, Wartchow EP, Jones K, Ting LH, Jankowski C, Kelher MR, Manco-Johnson M, Feser ML, Deane KD, Nemkov T, D'Alessandro A, Thorburn A, Maycotte P, López JA, Davizon-Castillo P. TNF-a impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation. J Clin Invest. 2025 Aug 01; 135(15).
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Larson EA, Smith LE, Perng W, Switkowski KM, Rifas-Shiman SL, Oken E. The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva. J Nutr. 2025 Jun; 155(6):1999-2005.
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Lee GY, Schaunaman N, Nouri HR, Kraft M, Chu HW. Comprehensive single-cell RNA-sequencing study of Tollip deficiency effect in IL-13-stimulated human airway epithelial cells. BMC Res Notes. 2025 Apr 23; 18(1):194.
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Chilukuri A, Kim M, Mitra T, Gubatan JM, Urrete J, Saxon LD, Ablack A, Mikulski Z, Dobaczewska K, Shen Z, Keir M, Yi T, Kaur P, Oliveira P, Murillo-Saich J, Chang EY, Steiner CA, Jedlicka P, Guma M, Rivera-Nieves J. A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice. Inflamm Bowel Dis. 2025 Apr 10; 31(4):1067-1081.
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Uzen R, Bayram F, Dursun H, Kardas F, Cakir M, Cucer N, Eken A, Donmez-Altuntas H. The number and frequency of mucosal-associated invariant T (MAIT), ?d T, and innate lymphoid cells (ILCs) altered in patients with type I Gaucher disease. Hum Immunol. 2025 May; 86(3):111302.
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Ishikawa T, Nishimura K, Okamoto N, Akamine K, Inoue N, Irabu H, Kato K, Keino H, Kojima M, Kubo H, Maruyama K, Mizuta M, Shabana K, Shimizu M, Sugita Y, Takakuwa Y, Takanashi S, Takase H, Umebayashi H, Umezawa N, Yamanishi S, Yamazaki K, Yashiro M, Yasumi T, Mori M. Efficacy and safety of tumor necrosis factor inhibitors for systemic juvenile idiopathic arthritis: A systematic review. Mod Rheumatol. 2024 Dec 25; 35(1):174-184.
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Shearn CT, Anderson AL, Devereaux MW, Koch SD, Larsen LD, Spencer LA, Orlicky DJ, Colgan SP, Steiner CA, Sokol RJ. Overexpression of TNFa in TNF?ARE+/- mice increases hepatic periportal inflammation and alters bile acid signaling in mice. Hepatol Commun. 2024 Dec 01; 8(12).
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Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S, Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB. Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis. Nat Commun. 2024 11 14; 15(1):9859.
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Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nat Commun. 2024 10 29; 15(1):9339.
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