Insulin
"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
| Descriptor ID |
D007328
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| MeSH Number(s) |
D06.472.699.587.200.500.625 D12.644.548.586.200.500.625
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| Concept/Terms |
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
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Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in this website by year, and whether "Insulin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 8 | 6 | 14 | | 1997 | 7 | 6 | 13 | | 1998 | 8 | 8 | 16 | | 1999 | 10 | 10 | 20 | | 2000 | 9 | 9 | 18 | | 2001 | 11 | 8 | 19 | | 2002 | 12 | 6 | 18 | | 2003 | 16 | 13 | 29 | | 2004 | 24 | 22 | 46 | | 2005 | 14 | 16 | 30 | | 2006 | 13 | 22 | 35 | | 2007 | 17 | 29 | 46 | | 2008 | 19 | 21 | 40 | | 2009 | 22 | 42 | 64 | | 2010 | 28 | 14 | 42 | | 2011 | 21 | 28 | 49 | | 2012 | 25 | 33 | 58 | | 2013 | 22 | 27 | 49 | | 2014 | 17 | 39 | 56 | | 2015 | 25 | 30 | 55 | | 2016 | 29 | 30 | 59 | | 2017 | 24 | 34 | 58 | | 2018 | 30 | 34 | 64 | | 2019 | 36 | 37 | 73 | | 2020 | 30 | 36 | 66 | | 2021 | 21 | 45 | 66 | | 2022 | 9 | 74 | 83 | | 2023 | 6 | 52 | 58 | | 2024 | 43 | 27 | 70 | | 2025 | 44 | 15 | 59 | | 2026 | 21 | 21 | 42 |
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Below are the most recent publications written about "Insulin" by people in Profiles.
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Castro-Gutierrez R, Shilleh AH, Barra JM, Williams SPM, Nedumaran B, Triolo TM, Hebrok M, Russ HA. Physical and Biochemical Determinants of Endocrine Fate in 3D Suspension Culture Based Stem Cell-Derived ß-Cell Differentiation. Cells. 2026 Sep 02; 15(17).
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Haskins K, Delong T, DiLisio JE, Baker RL. Hybrid Insulin Peptides as Antigens and Tolerogens for Pathogenic T Cells in Autoimmune Diabetes. Immunol Rev. 2026 Aug; 341(1):e70142.
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Wenzlau JM, Mangold K, Nicholson K, Dang M, Hohenstein AC, Douglas KS, DiLisio JE, Powell R, Delong T, Haskins K, Baker RL. A novel region of the insulin B9-23 sequence is targeted by a HIP-reactive diabetogenic T cell clone. Front Immunol. 2026; 17:1837267.
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Sarbaugh D, Oliveira TG, Guney MA, Casey MR, Hoelscher VM, Hill CJ, Michel CR, Wells KL, Benninger RKP, Sussel L. CHD4 and NKX2.2 Cooperate to Regulate ß-Cell Function by Repressing Non-ß-Cell Gene Programs. Diabetes. 2026 07 01; 75(7):1189-1200.
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Martens TW, Patel BV, Wang SM, Messer LH, Pinsker JE, Malone DC, Polin MR, Brixner DI, Isaacs D, Ebekozien O. Impact of Automated Insulin Delivery on Type 2 Diabetes Measures. Am J Manag Care. 2026 Jul 01; 32(7):e222-e227.
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Cook TM, Bethea M, da Silva Teixeira S, Birznieks C, McClennan A, Hendrix J, Benninger RK, Patti ME, Sandoval DA. Dysregulated glucagon signaling contributes to hypoglycemia after vertical sleeve gastrectomy in mice. Mol Metab. 2026 Aug; 110:102399.
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Hitt TA, Kelly A, Stefanovski D, Zemel BS, McCarter R, Yanek L, Zandieh G, Özdemir I, Kamel IR, Hui SCN, Barker P, Magge SN. Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study. Diabetes Care. 2026 Jun 01; 49(6):1057-1066.
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Sinha R, Uz Zaman S, Mohamed RC, Singh A, Saxena D, Pati AK. Efficacy and Safety of Inhalational Insulin Compared With Rapid-Acting Insulin Analogs: A Systematic Review and Meta-Analysis. Clin Ther. 2026 Aug; 48(8):790-797.
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Saeed ZI, Shah VN. Clinical Guidance on the Safe Use of Glucagon-like Peptide-1 Receptor Agonists in Adults with Type 1 Diabetes. Endocrinol Metab Clin North Am. 2026 Sep; 55(3):525-536.
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Grammer EE, Stahl ME, Ortiz de Zevallos J, Paterson C, Weltman A, Allen JD. Influence of metformin on exercise metabolism and capacity: a systematic review and meta-analysis. Am J Physiol Endocrinol Metab. 2026 Jun 01; 330(6):E842-E859.
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