 NF-E2-Related Factor 2
"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.
| Descriptor ID |
D051267
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| MeSH Number(s) |
D12.776.260.108.737 D12.776.930.127.737
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| Concept/Terms |
NF-E2-Related Factor 2- NF-E2-Related Factor 2
- NF E2 Related Factor 2
- Nuclear Factor E2-Related Factor 2
- Nuclear Factor E2 Related Factor 2
- Nfe2l2 Protein
- Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein
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Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".
Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".
This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 4 | 0 | 4 | | 2009 | 1 | 2 | 3 | | 2011 | 3 | 2 | 5 | | 2012 | 3 | 0 | 3 | | 2013 | 5 | 1 | 6 | | 2014 | 2 | 3 | 5 | | 2015 | 1 | 1 | 2 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 0 | 2 | | 2018 | 3 | 0 | 3 | | 2019 | 3 | 2 | 5 | | 2020 | 2 | 1 | 3 | | 2021 | 2 | 1 | 3 | | 2022 | 2 | 6 | 8 | | 2023 | 0 | 2 | 2 | | 2025 | 1 | 3 | 4 | | 2026 | 1 | 0 | 1 |
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Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.
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Gu W, Ren Z, Gao J, Shen Z, Wang Y, Xu L, Qian R, Miao Q, Wu Y, Hu X, Wu Y, Liu W, Wan CC, Sun L, Cai Y, Sang M, Zheng C, Yan T. Inhibiting NAT10 suppresses hepatocellular carcinoma progression by reducing Nrf2 mRNA stability and increasing oxidative stress. Chem Biol Interact. 2026 Apr 25; 429:111972.
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Signoretti C, Fatehi S, Drewes R, Cendali F, Dzieciatkowska M, D'Alessandro A, Bae Y, Gupte SA. Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency. Am J Physiol Lung Cell Mol Physiol. 2026 02 01; 330(2):L145-L158.
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Affandi T, Ohm AM, Speidel JT, Caino MC, Boulton DP, Reyland ME. PKCd Regulates DNA Damage and Cell Death through a SIRT6/Nrf2-dependent Antioxidant Response. Mol Cancer Res. 2025 09 04; 23(9):779-791.
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McGivney GR, Brockman QR, Borcherding N, Scherer A, Rauckhorst AJ, Gutierrez WR, Solst SR, Heer CD, Warrier A, Floyd W, Kirsch DG, Knepper-Adrian VL, Laverty EA, Roughton GA, Spitz DR, Taylor EB, Dodd RD. Somatic CRISPR tumorigenesis and multiomic analysis reveal a pentose phosphate pathway disruption vulnerability in MPNSTs. Sci Adv. 2025 Aug 15; 11(33):eadu2906.
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Grayck MR, Smith BJ, Sosa A, Golden E, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Dobrinskikh E, Rincon M, McCulley DJ, Orlicky DJ, Wright CJ. A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung. Am J Respir Cell Mol Biol. 2025 08; 73(2):232-250.
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Profeta V, McIntyre K, Wells M, Park C, Lynch DR. Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia. Expert Opin Investig Drugs. 2023 Jan; 32(1):5-16.
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Iams WT, Balbach ML, Phillips S, Sacher A, Bestvina C, Velcheti V, Wang X, Marmarelis ME, Sethakorn N, Leal T, Sackstein PE, Kim C, Robinson MA, Mehta K, Hsu R, Nieva J, Patil T, Camidge DR. A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer. Clin Lung Cancer. 2023 05; 24(3):228-234.
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Ide S, Ide K, Abe K, Kobayashi Y, Kitai H, McKey J, Strausser SA, O'Brien LL, Tata A, Tata PR, Souma T. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep. 2022 11 08; 41(6):111610.
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Sato Y, Saito S, Nakayama M, Sugita S, Kudo A, Keino H. Genetic Ablation of Nrf2 Exacerbates Neuroinflammation in Ocular Autoimmunity. Int J Mol Sci. 2022 Oct 03; 23(19).
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Musci RV, Andrie KM, Walsh MA, Valenti ZJ, Linden MA, Afzali MF, Bork S, Campbell M, Johnson T, Kail TE, Martinez R, Nguyen T, Sanford J, Wist S, Murrell MD, McCord JM, Hybertson BM, Zhang Q, Javors MA, Santangelo KS, Hamilton KL. Phytochemical compound PB125 attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a model of musculoskeletal decline. J Physiol. 2023 06; 601(11):2189-2216.
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