 Macrophage Activation
"Macrophage Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
| Descriptor ID |
D008262
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| MeSH Number(s) |
G12.287.500
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| Concept/Terms |
Macrophage Activation- Macrophage Activation
- Activation, Macrophage
- Activations, Macrophage
- Macrophage Activations
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Below are MeSH descriptors whose meaning is more general than "Macrophage Activation".
Below are MeSH descriptors whose meaning is more specific than "Macrophage Activation".
This graph shows the total number of publications written about "Macrophage Activation" by people in this website by year, and whether "Macrophage Activation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 4 | 4 | | 1996 | 1 | 0 | 1 | | 1997 | 2 | 0 | 2 | | 1998 | 2 | 0 | 2 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 3 | 2 | 5 | | 2006 | 1 | 3 | 4 | | 2007 | 3 | 3 | 6 | | 2008 | 3 | 4 | 7 | | 2009 | 2 | 1 | 3 | | 2010 | 4 | 0 | 4 | | 2011 | 3 | 2 | 5 | | 2012 | 3 | 3 | 6 | | 2013 | 2 | 3 | 5 | | 2014 | 2 | 5 | 7 | | 2015 | 1 | 3 | 4 | | 2016 | 0 | 5 | 5 | | 2017 | 4 | 4 | 8 | | 2018 | 5 | 1 | 6 | | 2019 | 2 | 4 | 6 | | 2020 | 2 | 3 | 5 | | 2021 | 4 | 4 | 8 | | 2022 | 1 | 1 | 2 | | 2023 | 0 | 2 | 2 | | 2024 | 1 | 0 | 1 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Macrophage Activation" by people in Profiles.
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Lakshmanachetty S, Riemondy K, Sanford B, Donson A, Chen V, Balakrishnan I, Prince EW, Hankinson T, Dahl N, Vibhakar R, Foreman N, Venkatraman S, Mitra SS. Differential phagocytosis induces diverse macrophage activation states in malignant gliomas. J Immunother Cancer. 2025 Sep 05; 13(9).
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Smith MH, Parker RR, Patrick KL, Courvan EMC. Plans within plans: post-transcriptional regulation governs macrophage responses. Trends Immunol. 2025 Aug; 46(8):573-585.
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Matsuzaki H, Kai K, Komohara Y, Yano H, Pan C, Fujiwara Y, Yamada R, Iwauchi A, Fukasawa N, Tanaka T, Shimoda M, Watanabe H, Maruyama T, Takeo T, Mikami Y, Mukasa A. Abnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages. Cancer Sci. 2025 Apr; 116(4):897-909.
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Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nat Commun. 2024 May 18; 15(1):4235.
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Kaneko S, Shimizu M, Miyaoka F, Shimbo A, Irabu H, Mizuta M, Nakagishi Y, Iwata N, Fujimura J, Mori M, Morio T. The dynamics of laboratory markers reflecting cytokine overproduction in macrophage activation syndrome complicated with systemic juvenile idiopathic arthritis. Clin Immunol. 2023 03; 248:109270.
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Shearn CT, Anderson AL, Miller CG, Noyd RC, Devereaux MW, Balasubramaniyan N, Orlicky DJ, Schmidt EE, Sokol RJ. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. Hepatol Commun. 2023 01 01; 7(1):e0020.
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Kawaguchi S, Kawahara K, Fujiwara Y, Ohnishi K, Pan C, Yano H, Hirosue A, Nagata M, Hirayama M, Sakata J, Nakashima H, Arita H, Yamana K, Gohara S, Nagao Y, Maeshiro M, Iwamoto A, Hirayama M, Yoshida R, Komohara Y, Nakayama H. Naringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration. Cancer Immunol Immunother. 2022 Sep; 71(9):2127-2139.
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Saleh LS, Amer LD, Thompson BJ, Danhorn T, Knapp JR, Gibbings SL, Thomas S, Barthel L, O'Connor BP, Janssen WJ, Alper S, Bryant SJ. Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant. Adv Healthc Mater. 2022 05; 11(9):e2102209.
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El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology. 2022 02; 75(2):252-265.
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Pan C, Fujiwara Y, Horlad H, Iriki T, Shiraishi D, Komohara Y. Cyclic sulfur compounds targeting macrophage polarization into M2/protumor phenotype and their anti-tumor effects. Cancer Immunol Immunother. 2022 Jun; 71(6):1331-1343.
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