 NF-kappa B
"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
| Descriptor ID |
D016328
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| MeSH Number(s) |
D12.776.260.600 D12.776.660.600 D12.776.930.600
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| Concept/Terms |
NF-kappa B- NF-kappa B
- kappa B Enhancer Binding Protein
- NF-kappaB
- NF kappaB
- Transcription Factor NF-kB
- Factor NF-kB, Transcription
- NF-kB, Transcription Factor
- Transcription Factor NF kB
- NF-kB
- NF kB
- Immunoglobulin Enhancer-Binding Protein
- Enhancer-Binding Protein, Immunoglobulin
- Immunoglobulin Enhancer Binding Protein
- Nuclear Factor kappa B
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Below are MeSH descriptors whose meaning is more general than "NF-kappa B".
Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".
This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 4 | 1 | 5 | | 1996 | 4 | 2 | 6 | | 1997 | 4 | 3 | 7 | | 1998 | 4 | 1 | 5 | | 1999 | 1 | 5 | 6 | | 2000 | 9 | 4 | 13 | | 2001 | 5 | 8 | 13 | | 2002 | 7 | 12 | 19 | | 2003 | 12 | 10 | 22 | | 2004 | 12 | 7 | 19 | | 2005 | 11 | 16 | 27 | | 2006 | 4 | 10 | 14 | | 2007 | 6 | 16 | 22 | | 2008 | 7 | 17 | 24 | | 2009 | 7 | 12 | 19 | | 2010 | 5 | 13 | 18 | | 2011 | 3 | 17 | 20 | | 2012 | 6 | 15 | 21 | | 2013 | 6 | 13 | 19 | | 2014 | 11 | 16 | 27 | | 2015 | 6 | 5 | 11 | | 2016 | 2 | 11 | 13 | | 2017 | 2 | 9 | 11 | | 2018 | 5 | 3 | 8 | | 2019 | 3 | 12 | 15 | | 2020 | 8 | 4 | 12 | | 2021 | 7 | 6 | 13 | | 2022 | 2 | 5 | 7 | | 2023 | 3 | 6 | 9 | | 2024 | 2 | 10 | 12 | | 2025 | 2 | 4 | 6 |
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Below are the most recent publications written about "NF-kappa B" by people in Profiles.
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Thorne AJ, Gao A, Necker-Brown A, Bansal A, Kalyanaraman K, Chandramohan P, Sasse SK, Gerber AN, Mostafa MM, Newton R. Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid. Mol Pharmacol. 2025 Oct; 107(10):100073.
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de Sousa GR, Calzadilla AJ, Grimaldo E, Donson AM, Sobral LM, Jones KM, Liu T, Amani V, Venkataraman S, Dahl NA, Levy JMM, Phang T, Vibhakar R, Hankinson T, Handler M, Valera ET, Foreman NK, Griesinger AM. Loss of LDOC1 by chromatin compaction in mesenchymal tumor cells is required for PFA1 ependymoma growth. Neuro Oncol. 2025 Jul 30; 27(6):1597-1610.
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Ke Y, Boss MK, Burdekin B, Li BZ, Bian L, Wang D, Wang S, Lee BI, Gualtieri P, Trageser E, Young CD, Wang XJ. Identifying Pathogenic Contributors of Radiodermatitis Ameliorated by Smad7-Based Targeting in Canine and Mouse Models. Int J Radiat Oncol Biol Phys. 2025 Nov 01; 123(3):852-859.
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Rosenbaum SR, Hughes CJ, Fields KM, Purdy SC, Gustafson AL, Wolin A, Hampton D, Shrivastava NM, Turner N, Danis E, Ebmeier C, Spoelstra N, Richer J, Jedlicka P, Costello JC, Zhao R, Ford HL. EYA3 regulation of NF-?B and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis. Sci Adv. 2025 May 09; 11(19):eadt0504.
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Anton PE, Twardy S, Nagpal P, Moreno JA, Burchill MA, Chatterjee A, Busquet N, Mesches M, Kovacs EJ, McCullough RL. Suppression of NF-?B/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation. J Leukoc Biol. 2025 Apr 23; 117(4).
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Levy MV, Fandl HK, Hijmans JG, Stockelman KA, Ruzzene ST, Reiakvam WR, Goldthwaite ZA, Greiner JJ, DeSouza CA, Garcia VP. Effect of 17ß-Estradiol on Endothelial Cell Expression of Inflammation- Related MicroRNA. Microrna. 2025; 14(1):3-8.
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Schuetze KB, Stratton MS, Bagchi RA, Hobby ARH, Felisbino MB, Rubino M, Toni LS, Reges C, Cavasin MA, McMahan RH, Alexanian M, Vagnozzi RJ, McKinsey TA. BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression. Am J Physiol Heart Circ Physiol. 2025 Feb 01; 328(2):H294-H309.
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Chakraborty S, Cheng BY, Edwards DL, Gonzalez JC, Chiu DK, Zheng H, Scallan C, Guo X, Tan GS, Coffey GP, Conley PB, Hume PS, Janssen WJ, Byers DE, Mudd PA, Taubenberger J, Memoli M, Davis MM, Chua KF, Diamond MS, Andreakos E, Khatri P, Wang TT. Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease. Immunity. 2025 Jan 14; 58(1):182-196.e10.
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Luo Y, Su B, Hung V, Luo Y, Shi Y, Wang G, de Graaf D, Dinarello CA, Spaner DE. IL-1 receptor antagonism reveals a yin-yang relationship between NF?B and interferon signaling in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2024 Aug 13; 121(33):e2405644121.
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Necker-Brown A, Kooi C, Thorne AJ, Bansal A, Mostafa MM, Chandramohan P, Gao A, Kalyanaraman K, Milani A, Gill S, Georgescu A, Sasse SK, Gerber AN, Leigh R, Newton R. Inducible gene expression of I?B-kinase e is dependent on nuclear factor-?B in human pulmonary epithelial cells. Biochem J. 2024 07 17; 481(14):959-980.
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