 NF-kappa B
"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
| Descriptor ID |
D016328
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| MeSH Number(s) |
D12.776.260.600 D12.776.660.600 D12.776.930.600
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| Concept/Terms |
NF-kappa B- NF-kappa B
- kappa B Enhancer Binding Protein
- NF-kappaB
- NF kappaB
- Transcription Factor NF-kB
- Factor NF-kB, Transcription
- NF-kB, Transcription Factor
- Transcription Factor NF kB
- NF-kB
- NF kB
- Immunoglobulin Enhancer-Binding Protein
- Enhancer-Binding Protein, Immunoglobulin
- Immunoglobulin Enhancer Binding Protein
- Nuclear Factor kappa B
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Below are MeSH descriptors whose meaning is more general than "NF-kappa B".
Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".
This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1996 | 3 | 2 | 5 | | 1997 | 4 | 3 | 7 | | 1998 | 3 | 1 | 4 | | 1999 | 1 | 4 | 5 | | 2000 | 7 | 4 | 11 | | 2001 | 6 | 8 | 14 | | 2002 | 5 | 13 | 18 | | 2003 | 12 | 11 | 23 | | 2004 | 11 | 7 | 18 | | 2005 | 10 | 15 | 25 | | 2006 | 3 | 10 | 13 | | 2007 | 6 | 17 | 23 | | 2008 | 7 | 16 | 23 | | 2009 | 7 | 12 | 19 | | 2010 | 5 | 13 | 18 | | 2011 | 3 | 17 | 20 | | 2012 | 6 | 17 | 23 | | 2013 | 6 | 13 | 19 | | 2014 | 11 | 17 | 28 | | 2015 | 6 | 5 | 11 | | 2016 | 2 | 12 | 14 | | 2017 | 2 | 10 | 12 | | 2018 | 5 | 2 | 7 | | 2019 | 3 | 13 | 16 | | 2020 | 8 | 4 | 12 | | 2021 | 7 | 6 | 13 | | 2022 | 2 | 5 | 7 | | 2023 | 3 | 6 | 9 | | 2024 | 2 | 10 | 12 | | 2025 | 4 | 8 | 12 | | 2026 | 1 | 2 | 3 |
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Below are the most recent publications written about "NF-kappa B" by people in Profiles.
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Freeman ML, Fitzgerald W, Clagett BM, O'Hare KA, Jonnalagadda V, Wilson BM, Margolis L, Wu K, Tassiopoulos K, Shive CL, Erlandson KM. Frailty in People with HIV Is Linked to Inflammation, Bone Health, and T-Cell Exhaustion. J Infect Dis. 2026 Jun 16; 233(6):995-1004.
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Ke Y, Li BZ, Li F, Ravindran R, Wang D, Wang S, Hwang ST, Simon SI, Collins SR, Young CD, Wang XJ. Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs. Nat Commun. 2026 Mar 26; 17(1).
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Sripada A, Varma R, Sirohi K, Sahu A, Verma M, Alam R. Sprouty2 modulates NF-?B signaling by sequestering the phosphatase PP2Ac in LPS-stimulated macrophages. J Immunol. 2026 Mar 17; 215(3).
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Necker-Brown A, Mostafa MM, Georgescu A, Thorne AJ, Chandramohan P, Kooi C, Kalyanaraman K, Gao A, Bansal A, Sasse SK, Gerber AN, Leigh R, Newton R. Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-?B. PLoS One. 2025; 20(12):e0329244.
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O'Leary S, Prasai A, Robledo A, Thang C, Wang Y, Deshpande RR, Russell WK, Murton AJ, Wolf SE, El Ayadi A. Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury. Front Immunol. 2025; 16:1709256.
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Nam MH, Nahomi RB, Suk J, Panja S, Smith WC, Shan Y, Fort PE, Nagaraj RH. DJ-1 Protects Human Retinal Endothelial Cells From Diabetes-Related Conditions and Prevents Ischemic Damage in Mouse Retinal Capillaries. Invest Ophthalmol Vis Sci. 2025 Nov 03; 66(14):8.
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Shirasawa M, Nakajima R, Zhou Y, Fikriyanti M, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Transcriptional Activation Mechanisms and Target Genes of the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1. Genes (Basel). 2025 Oct 15; 16(10).
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Mishra N, Saba L, Agarwal C, Agarwal R. Dexamethasone alters the cornea transcriptome to confer protection against ocular sulfur mustard exposure via regulating NF?B and TGFß signaling in an in vivo rabbit model. Arch Toxicol. 2026 01; 100(1):305-319.
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Thorne AJ, Gao A, Necker-Brown A, Bansal A, Kalyanaraman K, Chandramohan P, Sasse SK, Gerber AN, Mostafa MM, Newton R. Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid. Mol Pharmacol. 2025 Oct; 107(10):100073.
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de Sousa GR, Calzadilla AJ, Grimaldo E, Donson AM, Sobral LM, Jones KM, Liu T, Amani V, Venkataraman S, Dahl NA, Levy JMM, Phang T, Vibhakar R, Hankinson T, Handler M, Valera ET, Foreman NK, Griesinger AM. Loss of LDOC1 by chromatin compaction in mesenchymal tumor cells is required for PFA1 ependymoma growth. Neuro Oncol. 2025 Jul 30; 27(6):1597-1610.
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