 Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
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| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
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| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
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Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1995 | 2 | 2 | 4 | | 1996 | 3 | 0 | 3 | | 1997 | 8 | 1 | 9 | | 1998 | 2 | 3 | 5 | | 1999 | 3 | 2 | 5 | | 2000 | 4 | 3 | 7 | | 2001 | 1 | 1 | 2 | | 2002 | 9 | 6 | 15 | | 2003 | 7 | 8 | 15 | | 2004 | 14 | 9 | 23 | | 2005 | 11 | 7 | 18 | | 2006 | 8 | 6 | 14 | | 2007 | 10 | 8 | 18 | | 2008 | 8 | 7 | 15 | | 2009 | 11 | 7 | 18 | | 2010 | 5 | 5 | 10 | | 2011 | 2 | 10 | 12 | | 2012 | 13 | 7 | 20 | | 2013 | 6 | 6 | 12 | | 2014 | 5 | 8 | 13 | | 2015 | 2 | 7 | 9 | | 2016 | 5 | 3 | 8 | | 2017 | 7 | 7 | 14 | | 2018 | 3 | 4 | 7 | | 2019 | 6 | 4 | 10 | | 2020 | 5 | 4 | 9 | | 2021 | 2 | 6 | 8 | | 2022 | 0 | 7 | 7 | | 2023 | 0 | 6 | 6 | | 2024 | 1 | 5 | 6 | | 2025 | 3 | 2 | 5 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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Scharf G, Davidson CR, Ustiyan V, Falkenberg LG, Adavalli A, Meeker JD, Morgan H, Ostmann AJ, Hudock KM, Brewington JJ, Clancy JP, Kramer EL. TGF-ß induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. Am J Physiol Lung Cell Mol Physiol. 2025 Oct 01; 329(4):L470-L479.
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Devi KSP, Wang E, Jaiswal A, Konieczny P, Kim TG, Nirschl CJ, Verma A, Liu Y, Milczanowski J, Christo SN, Gandolfo LC, Haitz K, Vardam TD, Wu P, King SL, Tse SW, Pradhan K, Jiang X, Tian T, Fuhlbrigge RC, Schmults CD, Clark RA, Kupper TS, Freeman GJ, Mackay LK, Naik S, Newell EW, Elemento O, Suarez-Farinas M, Anandasabapathy N. PD-1 is requisite for skin TRM cell formation and specification by TGFß. Nat Immunol. 2025 Aug; 26(8):1339-1351.
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Ke Y, Boss MK, Burdekin B, Li BZ, Bian L, Wang D, Wang S, Lee BI, Gualtieri P, Trageser E, Young CD, Wang XJ. Identifying Pathogenic Contributors of Radiodermatitis Ameliorated by Smad7-Based Targeting in Canine and Mouse Models. Int J Radiat Oncol Biol Phys. 2025 Nov 01; 123(3):852-859.
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Wilson TM, Bolt M, Stahly A, Lee JS, Bang TJ, Sachs PB, Deane KD, Humphries SM, Solomon JJ, Demoruelle MK. Transforming growth factor-beta is increased in sputum from individuals with rheumatoid arthritis-associated pulmonary fibrosis. Rheumatology (Oxford). 2025 Jun 01; 64(6):3989-3995.
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Niehaus C, Geanon D, Lietzau A, Jankovic M, Maucourant C, Maasoumy B, Sparrelid E, Wedemeyer H, Kahlhöfer J, Falk CS, Andrade IM, Ponzetta A, Björkström NK, Kraft ARM, Cornberg M, Strunz B. Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites. Eur J Immunol. 2025 Jun; 55(6):e51311.
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Nguyen KN, Graner AN, Fringuello AR, Zizzo Z, Valenzuela L, Anyanwu K, Lillehei KO, Youssef AS, Guzman S, Coughlan C, Graner MW. Extracellular Vesicles from a Novel Chordoma Cell Line, ARF-8, Promote Tumorigenic Microenvironmental Changes When Incubated with the Parental Cells and with Human Osteoblasts. Int J Mol Sci. 2024 Nov 27; 25(23).
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Lind HT, Hall SC, Strait AA, Goon JB, Aleman JD, Chen SMY, Karam SD, Young CD, Wang JH, Wang XJ. MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-? in squamous cell carcinomas with enhanced CD8 T cell memory-driven response. Cancer Lett. 2025 Jan 01; 608:217347.
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Santos ARMP, Kirkpatrick BE, Kim M, Anseth KS, Park Y. 2D co-culture model reveals a biophysical interplay between activated fibroblasts and cancer cells. Acta Biomater. 2024 12; 190:264-272.
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Muraoka S, Brodie WD, Mattichak MN, Gurrea-Rubio M, Ikari Y, Foster C, Amin MA, Khanna N, Amin H, Campbell PL, Vichaikul S, Model EN, Omara MM, Petrovski S, Kozicki K, Amarista C, Webber A, Ali M, Palisoc PJ, Hervoso J, Ruth JH, Tsoi LC, Varga J, Gudjonsson JE, Khanna D, Fox DA, Tsou PS. Targeting CD13/Aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis. Arthritis Rheumatol. 2025 Jan; 77(1):80-91.
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Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE. TGF-ßR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Sci Transl Med. 2024 01 31; 16(732):eadg6229.
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