 Actins
"Actins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
| Descriptor ID |
D000199
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| MeSH Number(s) |
D05.750.078.730.250 D12.776.210.500.100 D12.776.220.525.255
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Actins".
Below are MeSH descriptors whose meaning is more specific than "Actins".
This graph shows the total number of publications written about "Actins" by people in this website by year, and whether "Actins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 3 | 4 | | 1997 | 7 | 5 | 12 | | 1998 | 4 | 4 | 8 | | 1999 | 1 | 4 | 5 | | 2000 | 4 | 1 | 5 | | 2001 | 2 | 5 | 7 | | 2002 | 7 | 8 | 15 | | 2003 | 6 | 11 | 17 | | 2004 | 2 | 9 | 11 | | 2005 | 2 | 9 | 11 | | 2006 | 5 | 15 | 20 | | 2007 | 0 | 12 | 12 | | 2008 | 1 | 12 | 13 | | 2009 | 5 | 7 | 12 | | 2010 | 1 | 5 | 6 | | 2011 | 3 | 6 | 9 | | 2012 | 5 | 9 | 14 | | 2013 | 3 | 5 | 8 | | 2014 | 4 | 10 | 14 | | 2015 | 2 | 5 | 7 | | 2016 | 5 | 9 | 14 | | 2017 | 2 | 14 | 16 | | 2018 | 4 | 6 | 10 | | 2019 | 4 | 4 | 8 | | 2020 | 6 | 7 | 13 | | 2021 | 4 | 4 | 8 | | 2022 | 3 | 7 | 10 | | 2023 | 5 | 2 | 7 | | 2024 | 1 | 4 | 5 | | 2025 | 2 | 1 | 3 | | 2026 | 2 | 2 | 4 |
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Below are the most recent publications written about "Actins" by people in Profiles.
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Abaev-Schneiderman E, Nguyen L, Shalev R, Biton TE, Chopra A, Jagadeesan G, Sevilla-Sanchez D, Tickotsky Moskovitz N, Levin L, Feldman M, Van Rechem C, Levy D. ACTB methylation regulates SMARCA4 genomic occupancy to promote translation and reduce adhesion in colorectal cancer cells. Genome Res. 2026 04 07; 36(4):684-694.
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Bunner S, Huang K, Shah A, Figueroa S, Lang N, Chu C, Eskndir N, Pho M, Manning G, Zheng M, Fritz-Laylin L, Velle KB, Marcus J, Orth J, Stephens AD. Changes in nuclear and actin mechanics from G1 to G2 affect nuclear integrity. J Cell Sci. 2026 Jun 15; 139(12).
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Redente EF, Song T, Javkhlan N, Edelman BL, Foster DG, Wilson JA, Chakraborty S, Cooley JC, Gaurav R, Saguthi S, Seibold MA, Blumhagen RZ, Schwartz DA, Yang IV, Matsuda J, Bridges JP, Zemans RL, Tuder RM, Riches DWH. Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition. Nat Commun. 2026 Feb 28; 17(1).
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Wang M, Ghazal R, Srinivas AN, Nguyen TTL, Murthy V, McNamara DM, Skime MK, Batzler A, Jenkins GD, Barlera S, Pileggi S, Mestroni L, Merlo M, Pinet F, Krejcí J, Chaloupka A, de Groote P, Weinshilboum RM, Tschumperlin DJ, Liu D, Pereira NL. Novel association of NAV3 with dilated cardiomyopathy and its role in cardiac fibrosis. Am J Physiol Heart Circ Physiol. 2026 Mar 01; 330(3):H686-H696.
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Nguyen A, Jenkins GM, Brones PD, Parrett GA, Hagen GM, Bono JM, Risser DD. A new family of bacterial actin-like proteins regulates cell morphology in a filamentous cyanobacterium. mSphere. 2025 Nov 25; 10(11):e0049925.
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Mull ML, Pratt SJP, Thompson KN, Annis DA, Lee RM, Ju JA, Gilchrist DE, Stemberger MB, Boyman L, Lederer WJ, Vitolo MI, Martin SS. Disruption of P2Y2 Signaling Promotes Breast Tumor Cell Dissemination by Reducing ATP-Dependent Calcium Elevation and Actin Localization to Cell Junctions. Int J Mol Sci. 2025 May 01; 26(9).
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Cooperman B, McMurray M. Roles for the canonical polarity machinery in the de novo establishment of polarity in budding yeast spores. Mol Biol Cell. 2025 Mar 01; 36(3):ar28.
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Chakravarty D, Vedula P, Coffin M, Chen L, Sterling S, Peshkova AD, Suzuki A, Zhao L, Patra K, Assenmacher CA, Radaelli E, Levine M, Litvinov RI, Abrams CS, Fowler VM, Kashina A. ß-actin function in platelets and red blood cells can be performed by ?-actin and is therefore independent of actin isoform protein sequence. Mol Biol Cell. 2025 Feb 01; 36(2):ar18.
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Donaka R, Zheng H, Ackert-Bicknell CL, Karasik D. Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. Gene. 2025 Feb 05; 936:149123.
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Lazzarino M, Zanetti M, Chen SN, Gao S, Peña B, Lam CK, Wu JC, Taylor MRG, Mestroni L, Sbaizero O. Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations. Int J Mol Sci. 2024 Mar 03; 25(5).
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