 Phosphatidylinositol 4,5-Diphosphate
"Phosphatidylinositol 4,5-Diphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
| Descriptor ID |
D019269
|
| MeSH Number(s) |
D10.570.755.375.760.400.942.625.900
|
| Concept/Terms |
Phosphatidylinositol 4,5-Diphosphate- Phosphatidylinositol 4,5-Diphosphate
- 4,5-Diphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Diphosphate
- Phosphatidylinositol Phosphate, PtdIns(4,5)P2
- PtIns 4,5-P2
- PtdIns(4,5)P2
- PtdInsP
- PtdInsP2
- Phosphatidylinositol 4,5-Biphosphate
- 4,5-Biphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Biphosphate
- Phosphatidylinositol-4,5-Biphosphate
|
Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 4,5-Diphosphate".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 4,5-Diphosphate".
This graph shows the total number of publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in this website by year, and whether "Phosphatidylinositol 4,5-Diphosphate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 | | 1999 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 1 | 2 | | 2010 | 2 | 0 | 2 | | 2011 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in Profiles.
-
Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT. PIP2 corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity. Proc Natl Acad Sci U S A. 2021 04 27; 118(17).
-
Alnaas AA, Watson-Siriboe A, Tran S, Negussie M, Henderson JA, Osterberg JR, Chon NL, Harrott BM, Oviedo J, Lyakhova T, Michel C, Reisdorph N, Reisdorph R, Shearn CT, Lin H, Knight JD. Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin. J Biol Chem. 2021 Jan-Jun; 296:100159.
-
Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT. Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3569-E3577.
-
Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol. 2018 02; 38(2):344-352.
-
Effertz T, Becker L, Peng AW, Ricci AJ. Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation. J Neurosci. 2017 11 29; 37(48):11632-11646.
-
Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 2016 Nov 22; 55(46):6395-6405.
-
Shiozaki Y, Segawa H, Ohnishi S, Ohi A, Ito M, Kaneko I, Kido S, Tatsumi S, Miyamoto K. Relationship between sodium-dependent phosphate transporter (NaPi-IIc) function and cellular vacuole formation in opossum kidney cells. J Med Invest. 2015; 62(3-4):209-18.
-
Pilling C, Landgraf KE, Falke JJ. The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry. 2011 Nov 15; 50(45):9845-56.
-
Prekeris R. Actin regulation during abscission: unexpected roles of Rab35 and endocytic transport. Cell Res. 2011 Sep; 21(9):1283-5.
-
Lai CL, Landgraf KE, Voth GA, Falke JJ. Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCa C2 domain: a combined molecular dynamics and experimental study. J Mol Biol. 2010 Sep 17; 402(2):301-10.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|