An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

Descriptor ID	D000071199
MeSH Number(s)	D12.644.360.539.250
Concept/Terms	NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain Containing 3 Protein Cold Autoinflammatory Syndrome 1 Protein NACHT, LRR and PYD Domains-Containing Protein 3 NACHT, LRR and PYD Domains Containing Protein 3 NLRP3 Protein

Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".

Below are MeSH descriptors whose meaning is related to "NLR Family, Pyrin Domain-Containing 3 Protein".

Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".