Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colin Shearn

Concepts (291)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Cholestasis
10
2023
228
4.040
Why?
Aldehydes
15
2022
154
3.750
Why?
PTEN Phosphohydrolase
7
2018
143
2.930
Why?
Protein Carbonylation
10
2018
52
2.930
Why?
Liver Diseases, Alcoholic
12
2019
87
2.860
Why?
Liver
19
2022
1816
2.620
Why?
Ethanol
12
2019
575
2.100
Why?
Glutathione Transferase
8
2019
97
1.900
Why?
Antioxidants
7
2023
564
1.880
Why?
Cholangitis, Sclerosing
3
2023
75
1.610
Why?
Proto-Oncogene Proteins c-akt
6
2016
420
1.560
Why?
Oxidative Stress
14
2019
1178
1.390
Why?
Fatty Liver
3
2014
253
1.180
Why?
Inflammatory Bowel Diseases
3
2020
290
1.070
Why?
Fatty Liver, Alcoholic
2
2016
16
1.030
Why?
Carcinoma, Hepatocellular
3
2019
227
0.970
Why?
Thioredoxins
3
2018
30
0.960
Why?
Mice
34
2023
15520
0.900
Why?
AMP-Activated Protein Kinases
2
2014
178
0.850
Why?
Abdominal Injuries
1
2023
119
0.840
Why?
Protein Processing, Post-Translational
4
2016
408
0.790
Why?
Butylated Hydroxytoluene
2
2011
32
0.730
Why?
Hepatocytes
5
2021
205
0.690
Why?
Peroxiredoxins
2
2018
23
0.690
Why?
Bile Acids and Salts
5
2023
179
0.690
Why?
Animals
36
2023
33381
0.680
Why?
Liver Neoplasms
4
2019
527
0.670
Why?
NF-E2-Related Factor 2
2
2019
83
0.660
Why?
Thioredoxin-Disulfide Reductase
1
2018
13
0.660
Why?
Parenteral Nutrition
4
2023
92
0.650
Why?
Gene Knockout Techniques
1
2018
105
0.630
Why?
Non-alcoholic Fatty Liver Disease
3
2017
280
0.620
Why?
Liver Diseases
2
2021
282
0.620
Why?
Hepatitis
1
2017
46
0.610
Why?
Mitochondrial Proteins
2
2015
226
0.590
Why?
Superoxide Dismutase
5
2019
339
0.580
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
9
0.570
Why?
End Stage Liver Disease
1
2017
73
0.570
Why?
Thioredoxin Reductase 1
3
2023
8
0.560
Why?
Liver Cirrhosis, Alcoholic
1
2015
19
0.550
Why?
Tandem Mass Spectrometry
5
2022
421
0.550
Why?
Signal Transduction
9
2021
4709
0.510
Why?
Mice, Inbred C57BL
14
2021
4908
0.510
Why?
Alcoholism
3
2018
717
0.510
Why?
Oxidants
2
2012
122
0.480
Why?
Mice, Knockout
8
2020
2680
0.480
Why?
Diet, High-Fat
2
2016
247
0.460
Why?
Disease Models, Animal
10
2021
3730
0.440
Why?
Dietary Fats
2
2018
322
0.410
Why?
RNA, Messenger
6
2023
2657
0.410
Why?
Lipid Peroxidation
4
2016
156
0.410
Why?
Xenobiotics
1
2011
25
0.400
Why?
Male
27
2022
57801
0.390
Why?
Liver Cirrhosis
2
2023
245
0.380
Why?
Chromatography, Liquid
4
2017
355
0.380
Why?
Hydrogen Peroxide
1
2012
305
0.380
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
20
0.370
Why?
Alcohol Drinking
1
2016
652
0.370
Why?
Cell Proliferation
3
2018
2275
0.370
Why?
Glutathione Reductase
3
2019
22
0.360
Why?
Receptors, Cytoplasmic and Nuclear
2
2021
195
0.360
Why?
Tumor Necrosis Factor-alpha
4
2023
1171
0.360
Why?
Mitochondria
4
2019
786
0.360
Why?
Inflammation
5
2023
2566
0.350
Why?
Down-Regulation
1
2011
627
0.330
Why?
Carcinoma
1
2010
204
0.330
Why?
Blotting, Western
4
2016
1194
0.320
Why?
Alcohol Oxidoreductases
1
2008
57
0.320
Why?
Colonic Neoplasms
1
2010
224
0.310
Why?
Carcinogens
1
2008
108
0.310
Why?
Catalase
2
2017
123
0.310
Why?
Autophagy
2
2022
315
0.290
Why?
Phosphoric Monoester Hydrolases
1
2007
57
0.290
Why?
NF-kappa B
2
2021
670
0.280
Why?
Glutathione
4
2019
324
0.280
Why?
Hep G2 Cells
3
2021
73
0.270
Why?
Alanine Transaminase
3
2016
152
0.270
Why?
Case-Control Studies
3
2018
3171
0.270
Why?
Humans
27
2023
118974
0.260
Why?
Protein Kinase Inhibitors
1
2011
811
0.260
Why?
Up-Regulation
2
2019
872
0.260
Why?
Biomarkers
1
2015
3588
0.260
Why?
Proteomics
4
2019
876
0.260
Why?
Recombinant Proteins
4
2020
1308
0.250
Why?
Macrophage Activation
2
2023
168
0.250
Why?
Gene Expression Regulation
5
2021
2445
0.250
Why?
Enzyme Inhibitors
1
2008
827
0.250
Why?
Epithelial Cells
1
2010
963
0.240
Why?
Lipoproteins
2
2021
162
0.240
Why?
Phosphorylation
3
2014
1633
0.240
Why?
Genes, Regulator
1
2023
33
0.240
Why?
ARNTL Transcription Factors
1
2023
16
0.230
Why?
Cysteine Proteinase Inhibitors
2
2014
50
0.230
Why?
Sulfhydryl Compounds
2
2018
179
0.220
Why?
Prostatic Neoplasms
1
2010
940
0.220
Why?
Insulin Resistance
1
2011
1180
0.220
Why?
Fatty Acid-Binding Proteins
2
2013
62
0.220
Why?
Triglycerides
2
2016
519
0.210
Why?
Mitochondria, Liver
2
2013
70
0.210
Why?
Enzyme Activation
3
2013
828
0.210
Why?
Dioxanes
1
2021
8
0.210
Why?
Oxidation-Reduction
3
2019
940
0.210
Why?
Phytosterols
1
2021
9
0.200
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
150
0.200
Why?
Isoxazoles
1
2021
56
0.200
Why?
Cholesterol
2
2020
373
0.190
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
25
0.190
Why?
Models, Molecular
4
2014
1435
0.190
Why?
Mucoproteins
1
2020
11
0.190
Why?
Phosphatidylcholines
1
2020
133
0.180
Why?
Vesicular Transport Proteins
1
2020
84
0.180
Why?
Liposomes
1
2020
151
0.180
Why?
Cell Adhesion Molecules
1
2020
180
0.180
Why?
Gene Expression
2
2021
1489
0.170
Why?
Chromatography, High Pressure Liquid
2
2013
490
0.170
Why?
Acylation
1
2019
28
0.170
Why?
Lysosomes
1
2019
136
0.170
Why?
Colon
1
2020
238
0.160
Why?
PPAR alpha
2
2016
56
0.160
Why?
Female
9
2021
61565
0.160
Why?
Ribosomes
1
2019
142
0.160
Why?
Lung
1
2011
3664
0.160
Why?
Heme Oxygenase-1
1
2018
53
0.160
Why?
Mice, 129 Strain
1
2018
75
0.160
Why?
Sulfinic Acids
1
2018
7
0.160
Why?
Colitis
1
2020
219
0.160
Why?
Reactive Oxygen Species
2
2011
576
0.160
Why?
Aminobutyrates
1
2018
32
0.160
Why?
Pyruvaldehyde
1
2018
29
0.160
Why?
Azo Compounds
1
2017
25
0.160
Why?
Organ Specificity
1
2018
278
0.150
Why?
Taurine
1
2018
46
0.150
Why?
Malnutrition
1
2018
66
0.150
Why?
HSP70 Heat-Shock Proteins
1
2017
74
0.150
Why?
Protein Structure, Secondary
1
2018
338
0.150
Why?
Middle Aged
4
2019
27617
0.150
Why?
Homocystinuria
1
2018
63
0.150
Why?
Gene Deletion
2
2015
361
0.150
Why?
Mice, Inbred BALB C
2
2011
1206
0.150
Why?
Cell Line, Tumor
3
2020
2851
0.140
Why?
Amino Acid Sequence
4
2015
2071
0.140
Why?
Adult
4
2019
31512
0.140
Why?
Lipogenesis
1
2016
66
0.140
Why?
Fatty Acids, Unsaturated
1
2016
86
0.130
Why?
Lysine
1
2017
248
0.130
Why?
Sirtuin 3
2
2019
60
0.130
Why?
Proteome
1
2019
353
0.130
Why?
Acetylation
4
2017
217
0.130
Why?
Cytochrome P-450 CYP4A
1
2014
6
0.130
Why?
Protein Isoforms
1
2015
345
0.120
Why?
CD36 Antigens
1
2014
42
0.120
Why?
Protein Binding
4
2020
1975
0.120
Why?
Endoplasmic Reticulum Stress
1
2014
97
0.120
Why?
Heat-Shock Proteins
1
2014
129
0.120
Why?
Phosphatidylinositol 3-Kinases
2
2013
341
0.120
Why?
Central Nervous System Depressants
1
2014
89
0.120
Why?
Adenosine Triphosphatases
1
2014
158
0.120
Why?
Computational Biology
1
2017
588
0.110
Why?
DNA Primers
2
2012
533
0.110
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
26
0.110
Why?
Carrier Proteins
1
2017
726
0.110
Why?
Acetyl-CoA Carboxylase
1
2013
38
0.110
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
57
0.110
Why?
Molecular Sequence Data
3
2015
2871
0.110
Why?
Endoplasmic Reticulum
2
2014
241
0.110
Why?
Polymerase Chain Reaction
2
2016
1012
0.110
Why?
Models, Chemical
1
2014
274
0.110
Why?
Organ Size
1
2013
460
0.100
Why?
Reactive Nitrogen Species
1
2011
25
0.100
Why?
Glycogen Synthase Kinase 3 beta
1
2011
65
0.100
Why?
Adiponectin
1
2013
226
0.100
Why?
Peptide Mapping
1
2011
63
0.100
Why?
Glycogen Synthase Kinase 3
1
2011
83
0.100
Why?
Binding Sites
2
2020
1224
0.100
Why?
Oxygen Consumption
1
2013
586
0.090
Why?
Crotonates
1
2010
3
0.090
Why?
Toluidines
1
2010
5
0.090
Why?
Hydroxybutyrates
1
2010
11
0.090
Why?
Fenretinide
1
2010
4
0.090
Why?
Receptors, Estrogen
1
2013
387
0.090
Why?
Tumor Cells, Cultured
1
2012
874
0.090
Why?
Cell Line, Transformed
1
2010
136
0.090
Why?
Microscopy, Confocal
1
2011
314
0.090
Why?
Nitriles
1
2010
155
0.090
Why?
Fluorescence Resonance Energy Transfer
1
2011
183
0.090
Why?
Protein Conformation
1
2012
848
0.090
Why?
Glycoproteins
1
2011
319
0.090
Why?
Cell Survival
1
2012
1047
0.080
Why?
Alkylation
1
2008
19
0.080
Why?
Nuclear Proteins
1
2013
597
0.080
Why?
DNA Damage
2
2021
357
0.080
Why?
Cytosol
1
2008
221
0.080
Why?
RNA, Small Interfering
1
2010
564
0.080
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
171
0.080
Why?
Kidney
1
2015
1353
0.080
Why?
Base Sequence
1
2011
2159
0.070
Why?
Phosphatidylinositol Phosphates
1
2007
38
0.070
Why?
Lung Neoplasms
2
2011
2220
0.070
Why?
Static Electricity
1
2007
121
0.070
Why?
Hydrolysis
1
2007
176
0.070
Why?
Cells, Cultured
2
2013
4077
0.070
Why?
Immunohistochemistry
1
2011
1691
0.070
Why?
Amino Acid Substitution
1
2007
276
0.070
Why?
Cloning, Molecular
2
2020
546
0.070
Why?
Peptides
1
2011
879
0.070
Why?
Skin
1
2010
657
0.070
Why?
Rats, Sprague-Dawley
1
2011
2478
0.070
Why?
Metabolome
2
2019
296
0.070
Why?
Phospholipids
1
2007
208
0.070
Why?
Transcription Factors
1
2013
1570
0.060
Why?
Biomarkers, Tumor
1
2011
1059
0.060
Why?
Glycosylation
2
2016
129
0.060
Why?
Amino Acids
2
2018
465
0.060
Why?
Rats
1
2011
5392
0.050
Why?
Sterols
1
2021
17
0.050
Why?
Multidrug Resistance-Associated Proteins
1
2021
36
0.050
Why?
Systems Analysis
1
2021
23
0.050
Why?
Intestinal Diseases
1
2021
30
0.050
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
106
0.050
Why?
Fatty Acids
2
2016
407
0.050
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
79
0.050
Why?
Bilirubin
1
2021
95
0.050
Why?
Infliximab
1
2021
94
0.050
Why?
Gas Chromatography-Mass Spectrometry
1
2021
135
0.050
Why?
Chromatin Immunoprecipitation
1
2021
136
0.050
Why?
Protein Conformation, beta-Strand
1
2020
16
0.050
Why?
Sphingomyelins
1
2020
29
0.050
Why?
Ursodeoxycholic Acid
1
2020
22
0.050
Why?
Phosphatidylinositols
1
2020
52
0.050
Why?
Calcium
1
2007
1169
0.050
Why?
Phosphatidylethanolamines
1
2020
66
0.050
Why?
Dextran Sulfate
1
2020
71
0.050
Why?
Molecular Docking Simulation
1
2020
101
0.050
Why?
Apoptosis
1
2010
2484
0.050
Why?
Phosphatidylserines
1
2020
91
0.050
Why?
Gene Knockdown Techniques
1
2021
311
0.050
Why?
Protein Interaction Domains and Motifs
1
2020
138
0.050
Why?
Lipid Bilayers
1
2020
100
0.040
Why?
Genetic Vectors
1
2020
302
0.040
Why?
Crystallography, X-Ray
1
2020
422
0.040
Why?
Interleukin-1beta
1
2021
379
0.040
Why?
Aged
1
2017
19657
0.040
Why?
Molecular Dynamics Simulation
1
2020
213
0.040
Why?
Sirtuins
1
2019
34
0.040
Why?
Disease Susceptibility
1
2020
331
0.040
Why?
gamma-Glutamyltransferase
1
2018
43
0.040
Why?
Metabolic Networks and Pathways
1
2019
176
0.040
Why?
Cystathionine beta-Synthase
1
2018
60
0.040
Why?
F2-Isoprostanes
1
2016
17
0.040
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.040
Why?
Sumoylation
1
2016
16
0.040
Why?
Escherichia coli
1
2020
758
0.040
Why?
Insulin-Secreting Cells
1
2020
330
0.040
Why?
Oxides
1
2016
42
0.040
Why?
Mutation
1
2007
3457
0.030
Why?
Methylation
1
2016
204
0.030
Why?
Chemokine CXCL2
1
2014
44
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
25
0.030
Why?
Macrophages
1
2021
1324
0.030
Why?
Oxidative Phosphorylation
1
2015
156
0.030
Why?
Lipopolysaccharide Receptors
1
2014
88
0.030
Why?
Unfolded Protein Response
1
2014
46
0.030
Why?
Matrix Metalloproteinases
1
2014
90
0.030
Why?
Protein Folding
1
2014
250
0.030
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.030
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
144
0.030
Why?
Actins
1
2014
404
0.030
Why?
Antibodies
1
2014
392
0.030
Why?
Fibrosis
1
2014
483
0.030
Why?
Ubiquitination
1
2012
87
0.030
Why?
Lipid Metabolism
1
2015
477
0.030
Why?
Immunoprecipitation
1
2012
161
0.030
Why?
Transforming Growth Factor beta
1
2014
462
0.030
Why?
Gene Expression Regulation, Enzymologic
1
2013
290
0.030
Why?
Disease Progression
1
2019
2490
0.030
Why?
Protein Structure, Tertiary
1
2014
823
0.030
Why?
Microsomes, Liver
1
2011
59
0.020
Why?
Transcriptome
1
2016
756
0.020
Why?
NAD
1
2011
67
0.020
Why?
Sequence Alignment
1
2011
336
0.020
Why?
Hypoxia
1
2016
963
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
982
0.020
Why?
Computer Simulation
1
2014
922
0.020
Why?
Lipids
1
2013
607
0.020
Why?
Mass Spectrometry
1
2012
681
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1167
0.020
Why?
Mice, Transgenic
1
2013
2025
0.020
Why?
Cytokines
1
2014
1900
0.020
Why?
Genetic Predisposition to Disease
1
2013
2275
0.010
Why?
Adolescent
1
2016
18480
0.010
Why?
Child
1
2016
19129
0.010
Why?
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