Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colin Shearn

Concepts (302)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Protein Carbonylation
12
2025
57
3.570
Why?
Cholestasis
10
2023
214
3.500
Why?
Aldehydes
16
2025
140
3.390
Why?
Liver
22
2025
1899
2.760
Why?
PTEN Phosphohydrolase
7
2018
165
2.440
Why?
Liver Diseases, Alcoholic
12
2019
98
2.370
Why?
Bile Acids and Salts
7
2024
163
2.130
Why?
Oxidative Stress
16
2025
1360
1.860
Why?
Ethanol
12
2019
631
1.740
Why?
Antioxidants
7
2023
550
1.620
Why?
Glutathione Transferase
8
2019
92
1.610
Why?
Cholangitis, Sclerosing
4
2024
61
1.570
Why?
Parenteral Nutrition
5
2024
102
1.330
Why?
Proto-Oncogene Proteins c-akt
6
2016
440
1.320
Why?
Ileum
2
2024
112
1.000
Why?
Fatty Liver
3
2014
253
0.990
Why?
Mice
38
2025
18356
0.920
Why?
Tumor Necrosis Factor-alpha
5
2024
1217
0.910
Why?
Mice, Inbred C57BL
17
2025
5993
0.910
Why?
Inflammatory Bowel Diseases
3
2020
364
0.890
Why?
Fatty Liver, Alcoholic
2
2016
14
0.870
Why?
Insulin-Secreting Cells
3
2025
392
0.850
Why?
Signal Transduction
11
2024
5224
0.830
Why?
Thioredoxins
3
2018
30
0.810
Why?
Carcinoma, Hepatocellular
3
2019
373
0.710
Why?
Abdominal Injuries
1
2023
130
0.710
Why?
AMP-Activated Protein Kinases
2
2014
192
0.710
Why?
Animals
41
2025
38102
0.700
Why?
Protein Processing, Post-Translational
4
2016
473
0.650
Why?
Circadian Rhythm
1
2024
513
0.610
Why?
Butylated Hydroxytoluene
2
2011
37
0.610
Why?
Hepatocytes
5
2021
224
0.580
Why?
Peroxiredoxins
2
2018
25
0.580
Why?
Disease Models, Animal
13
2025
4568
0.580
Why?
Thioredoxin-Disulfide Reductase
1
2018
14
0.550
Why?
NF-E2-Related Factor 2
2
2019
101
0.550
Why?
Non-alcoholic Fatty Liver Disease
3
2017
265
0.540
Why?
Gene Knockout Techniques
1
2018
119
0.530
Why?
Hepatitis
1
2017
43
0.520
Why?
Liver Diseases
2
2021
305
0.510
Why?
Liver Cirrhosis
3
2024
288
0.500
Why?
Receptors, Cytoplasmic and Nuclear
3
2024
209
0.490
Why?
Superoxide Dismutase
5
2019
308
0.490
Why?
Mitochondrial Proteins
2
2015
263
0.490
Why?
Liver Neoplasms
4
2019
777
0.480
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
11
0.480
Why?
End Stage Liver Disease
1
2017
95
0.470
Why?
Thioredoxin Reductase 1
3
2023
8
0.470
Why?
Liver Cirrhosis, Alcoholic
1
2015
19
0.460
Why?
Tandem Mass Spectrometry
5
2022
572
0.430
Why?
Insulin
1
2025
2516
0.420
Why?
Oxidants
2
2012
99
0.410
Why?
Alcoholism
3
2018
826
0.410
Why?
ARNTL Transcription Factors
2
2024
17
0.410
Why?
Diet, High-Fat
2
2016
266
0.390
Why?
Inflammation
6
2025
2884
0.380
Why?
Mice, Knockout
8
2020
3130
0.380
Why?
Male
30
2025
73011
0.370
Why?
Dietary Fats
2
2018
308
0.360
Why?
Lipid Peroxidation
4
2016
168
0.340
Why?
Proteomics
5
2025
1188
0.340
Why?
RNA, Messenger
6
2023
2805
0.340
Why?
Xenobiotics
1
2011
30
0.330
Why?
Hydrogen Peroxide
1
2012
335
0.320
Why?
Reactive Oxygen Species
3
2025
611
0.320
Why?
Chromatography, Liquid
4
2017
450
0.310
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
27
0.310
Why?
Cell Proliferation
3
2018
2514
0.310
Why?
Glutathione Reductase
3
2019
24
0.310
Why?
Alcohol Drinking
1
2016
843
0.280
Why?
Down-Regulation
1
2011
618
0.280
Why?
Mitochondria
4
2019
993
0.280
Why?
Blotting, Western
4
2016
1184
0.280
Why?
Carcinoma
1
2010
227
0.270
Why?
Autophagy
2
2022
291
0.270
Why?
Alcohol Oxidoreductases
1
2008
61
0.270
Why?
Colonic Neoplasms
1
2010
258
0.260
Why?
Carcinogens
1
2008
123
0.260
Why?
Catalase
2
2017
134
0.260
Why?
Phosphoric Monoester Hydrolases
1
2007
55
0.250
Why?
NF-kappa B
2
2021
667
0.240
Why?
Glutathione
4
2019
370
0.230
Why?
Alanine Transaminase
3
2016
151
0.230
Why?
Hep G2 Cells
3
2021
73
0.230
Why?
Up-Regulation
2
2019
848
0.230
Why?
Case-Control Studies
3
2018
3634
0.220
Why?
Gene Expression Regulation
5
2021
2601
0.220
Why?
Recombinant Proteins
4
2020
1368
0.220
Why?
Enzyme Inhibitors
1
2008
821
0.210
Why?
Macrophage Activation
2
2023
181
0.210
Why?
Humans
28
2025
145783
0.210
Why?
Protein Kinase Inhibitors
1
2011
981
0.210
Why?
Ileitis
1
2024
33
0.210
Why?
Biomarkers
1
2015
4302
0.200
Why?
Phosphorylation
3
2014
1708
0.200
Why?
Mice, Inbred NOD
1
2025
616
0.200
Why?
Genes, Regulator
1
2023
35
0.200
Why?
Epithelial Cells
1
2010
1134
0.200
Why?
Lipoproteins
2
2021
166
0.200
Why?
Cysteine Proteinase Inhibitors
2
2014
49
0.190
Why?
Fibroblast Growth Factors
1
2024
188
0.190
Why?
Biliary Atresia
1
2025
158
0.190
Why?
Sulfhydryl Compounds
2
2018
189
0.190
Why?
Prostatic Neoplasms
1
2010
981
0.190
Why?
Insulin Resistance
1
2011
1244
0.180
Why?
Enzyme Activation
3
2013
762
0.180
Why?
Triglycerides
2
2016
520
0.180
Why?
Fatty Acid-Binding Proteins
2
2013
79
0.180
Why?
Mitochondria, Liver
2
2013
70
0.180
Why?
Dioxanes
1
2021
11
0.170
Why?
Phytosterols
1
2021
10
0.170
Why?
Isoxazoles
1
2021
56
0.170
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
166
0.170
Why?
Oxidation-Reduction
3
2019
1069
0.170
Why?
Mucoproteins
1
2020
8
0.160
Why?
Female
11
2025
79045
0.160
Why?
Models, Molecular
4
2014
1599
0.160
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
32
0.160
Why?
Cholesterol
2
2020
408
0.160
Why?
Vesicular Transport Proteins
1
2020
85
0.150
Why?
Phosphatidylcholines
1
2020
131
0.150
Why?
Gene Expression
2
2021
1478
0.150
Why?
Macrophages
2
2025
1507
0.150
Why?
Cell Adhesion Molecules
1
2020
181
0.150
Why?
Cytokines
2
2025
2069
0.150
Why?
Acylation
1
2019
30
0.140
Why?
Chromatography, High Pressure Liquid
2
2013
592
0.140
Why?
Lysosomes
1
2019
131
0.140
Why?
Liposomes
1
2020
263
0.140
Why?
PPAR alpha
2
2016
55
0.140
Why?
Mice, 129 Strain
1
2018
85
0.140
Why?
Sulfinic Acids
1
2018
6
0.130
Why?
Heme Oxygenase-1
1
2018
76
0.130
Why?
Ribosomes
1
2019
193
0.130
Why?
Colon
1
2020
309
0.130
Why?
Aminobutyrates
1
2018
31
0.130
Why?
Lung
1
2011
4116
0.130
Why?
Azo Compounds
1
2017
30
0.130
Why?
Taurine
1
2018
41
0.130
Why?
Organ Specificity
1
2018
309
0.130
Why?
Colitis
1
2020
281
0.130
Why?
Pyruvaldehyde
1
2018
46
0.130
Why?
HSP70 Heat-Shock Proteins
1
2017
75
0.130
Why?
Protein Structure, Secondary
1
2018
371
0.130
Why?
Gene Deletion
2
2015
392
0.130
Why?
Homocystinuria
1
2018
62
0.130
Why?
Mice, Inbred BALB C
2
2011
1261
0.120
Why?
Malnutrition
1
2018
86
0.120
Why?
Diabetes Mellitus
1
2025
1101
0.120
Why?
Amino Acid Sequence
4
2015
2131
0.120
Why?
Lipogenesis
1
2016
62
0.110
Why?
Cell Line, Tumor
3
2020
3551
0.110
Why?
Fatty Acids, Unsaturated
1
2016
96
0.110
Why?
Sirtuin 3
2
2019
60
0.110
Why?
Middle Aged
4
2019
36309
0.110
Why?
Lysine
1
2017
305
0.110
Why?
Cytochrome P-450 CYP4A
1
2014
4
0.110
Why?
Acetylation
4
2017
259
0.110
Why?
CD36 Antigens
1
2014
32
0.100
Why?
Protein Isoforms
1
2015
399
0.100
Why?
Proteome
1
2019
513
0.100
Why?
Adult
4
2019
40881
0.100
Why?
Central Nervous System Depressants
1
2014
84
0.100
Why?
Heat-Shock Proteins
1
2014
139
0.100
Why?
DNA Primers
2
2012
505
0.100
Why?
Protein Binding
4
2020
2240
0.100
Why?
Phosphatidylinositol 3-Kinases
2
2013
383
0.100
Why?
Carrier Proteins
1
2017
729
0.100
Why?
Adenosine Triphosphatases
1
2014
159
0.100
Why?
Endoplasmic Reticulum Stress
1
2014
118
0.100
Why?
Molecular Sequence Data
3
2015
2883
0.100
Why?
Acetyl-CoA Carboxylase
1
2013
32
0.100
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
26
0.100
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
56
0.100
Why?
Models, Chemical
1
2014
250
0.090
Why?
Computational Biology
1
2017
669
0.090
Why?
Endoplasmic Reticulum
2
2014
264
0.090
Why?
Polymerase Chain Reaction
2
2016
1043
0.090
Why?
Organ Size
1
2013
461
0.090
Why?
Reactive Nitrogen Species
1
2011
16
0.080
Why?
Peptide Mapping
1
2011
62
0.080
Why?
Adiponectin
1
2013
242
0.080
Why?
Diabetes Mellitus, Type 2
1
2025
2602
0.080
Why?
Glycogen Synthase Kinase 3 beta
1
2011
74
0.080
Why?
Glycogen Synthase Kinase 3
1
2011
83
0.080
Why?
Binding Sites
2
2020
1311
0.080
Why?
Fenretinide
1
2010
3
0.080
Why?
Crotonates
1
2010
7
0.080
Why?
Receptors, Estrogen
1
2013
404
0.080
Why?
Toluidines
1
2010
10
0.080
Why?
Hydroxybutyrates
1
2010
15
0.080
Why?
Tumor Cells, Cultured
1
2012
887
0.080
Why?
Oxygen Consumption
1
2013
719
0.080
Why?
Cell Line, Transformed
1
2010
138
0.080
Why?
Microscopy, Confocal
1
2011
319
0.080
Why?
Fluorescence Resonance Energy Transfer
1
2011
179
0.070
Why?
Protein Conformation
1
2012
938
0.070
Why?
Glycoproteins
1
2011
354
0.070
Why?
Cell Survival
1
2012
1104
0.070
Why?
Nitriles
1
2010
211
0.070
Why?
Alkylation
1
2008
27
0.070
Why?
Diabetes Mellitus, Type 1
1
2025
3937
0.070
Why?
Nuclear Proteins
1
2013
740
0.070
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
174
0.070
Why?
RNA, Small Interfering
1
2010
638
0.070
Why?
Cytosol
1
2008
213
0.070
Why?
Base Sequence
1
2011
2171
0.060
Why?
DNA Damage
2
2021
437
0.060
Why?
Kidney
1
2015
1497
0.060
Why?
Cells, Cultured
2
2013
4151
0.060
Why?
Phosphatidylinositol Phosphates
1
2007
41
0.060
Why?
Static Electricity
1
2007
114
0.060
Why?
Immunohistochemistry
1
2011
1723
0.060
Why?
Hydrolysis
1
2007
197
0.060
Why?
Lung Neoplasms
2
2011
2668
0.060
Why?
Cloning, Molecular
2
2020
538
0.060
Why?
Amino Acid Substitution
1
2007
302
0.060
Why?
Phospholipids
1
2007
214
0.060
Why?
Rats, Sprague-Dawley
1
2011
2525
0.060
Why?
Peptides
1
2011
999
0.050
Why?
Skin
1
2010
754
0.050
Why?
Metabolome
2
2019
391
0.050
Why?
Kupffer Cells
1
2025
52
0.050
Why?
Transcription Factors
1
2013
1736
0.050
Why?
Biomarkers, Tumor
1
2011
1329
0.050
Why?
Glycosylation
2
2016
173
0.050
Why?
Amino Acids
2
2018
519
0.050
Why?
Rats
1
2011
5585
0.050
Why?
Sterols
1
2021
20
0.040
Why?
Systems Analysis
1
2021
22
0.040
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
80
0.040
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
110
0.040
Why?
Intestinal Diseases
1
2021
43
0.040
Why?
Apoptosis
1
2010
2444
0.040
Why?
Bilirubin
1
2021
99
0.040
Why?
Fatty Acids
2
2016
457
0.040
Why?
Gas Chromatography-Mass Spectrometry
1
2021
125
0.040
Why?
Infliximab
1
2021
111
0.040
Why?
Chromatin Immunoprecipitation
1
2021
139
0.040
Why?
Protein Conformation, beta-Strand
1
2020
18
0.040
Why?
Sphingomyelins
1
2020
22
0.040
Why?
Ursodeoxycholic Acid
1
2020
17
0.040
Why?
Calcium
1
2007
1191
0.040
Why?
Phosphatidylinositols
1
2020
58
0.040
Why?
Phosphatidylserines
1
2020
62
0.040
Why?
Phosphatidylethanolamines
1
2020
77
0.040
Why?
Gene Knockdown Techniques
1
2021
334
0.040
Why?
Molecular Docking Simulation
1
2020
119
0.040
Why?
Dextran Sulfate
1
2020
93
0.040
Why?
Protein Interaction Domains and Motifs
1
2020
145
0.040
Why?
Lipid Bilayers
1
2020
103
0.040
Why?
Interleukin-1beta
1
2021
390
0.040
Why?
Genetic Vectors
1
2020
335
0.040
Why?
Crystallography, X-Ray
1
2020
486
0.040
Why?
Disease Susceptibility
1
2020
344
0.040
Why?
Molecular Dynamics Simulation
1
2020
265
0.030
Why?
Sirtuins
1
2019
50
0.030
Why?
Metabolic Networks and Pathways
1
2019
175
0.030
Why?
gamma-Glutamyltransferase
1
2018
42
0.030
Why?
Gene Expression Profiling
1
2025
1777
0.030
Why?
Cystathionine beta-Synthase
1
2018
65
0.030
Why?
Aged
1
2017
26217
0.030
Why?
F2-Isoprostanes
1
2016
21
0.030
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.030
Why?
Sumoylation
1
2016
16
0.030
Why?
Escherichia coli
1
2020
835
0.030
Why?
Oxides
1
2016
47
0.030
Why?
Methylation
1
2016
242
0.030
Why?
Mutation
1
2007
4090
0.030
Why?
Chemokine CXCL2
1
2014
41
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
31
0.030
Why?
Lipopolysaccharide Receptors
1
2014
88
0.030
Why?
Matrix Metalloproteinases
1
2014
95
0.030
Why?
Oxidative Phosphorylation
1
2015
209
0.030
Why?
Unfolded Protein Response
1
2014
58
0.030
Why?
Protein Folding
1
2014
277
0.020
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
146
0.020
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.020
Why?
Antibodies
1
2014
397
0.020
Why?
Actins
1
2014
426
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2013
267
0.020
Why?
Fibrosis
1
2014
561
0.020
Why?
Immunoprecipitation
1
2012
149
0.020
Why?
Transforming Growth Factor beta
1
2014
474
0.020
Why?
Protein Structure, Tertiary
1
2014
855
0.020
Why?
Ubiquitination
1
2012
119
0.020
Why?
Lipid Metabolism
1
2015
529
0.020
Why?
Disease Progression
1
2019
2865
0.020
Why?
Microsomes, Liver
1
2011
85
0.020
Why?
NAD
1
2011
79
0.020
Why?
Sequence Alignment
1
2011
362
0.020
Why?
Transcriptome
1
2016
1042
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
979
0.020
Why?
Computer Simulation
1
2014
1003
0.020
Why?
Mass Spectrometry
1
2012
732
0.020
Why?
Hypoxia
1
2016
1199
0.020
Why?
Lipids
1
2013
707
0.020
Why?
Mice, Transgenic
1
2013
2191
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1450
0.020
Why?
Genetic Predisposition to Disease
1
2013
2399
0.010
Why?
Adolescent
1
2016
22577
0.010
Why?
Child
1
2016
22740
0.010
Why?
Shearn's Networks
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