Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colin Shearn

Concepts (291)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Cholestasis
10
2023
225
3.790
Why?
Aldehydes
15
2022
138
3.490
Why?
PTEN Phosphohydrolase
7
2018
140
2.750
Why?
Protein Carbonylation
10
2018
51
2.720
Why?
Liver Diseases, Alcoholic
12
2019
81
2.680
Why?
Liver
19
2022
1633
2.560
Why?
Ethanol
12
2019
534
2.010
Why?
Antioxidants
7
2023
529
1.800
Why?
Glutathione Transferase
8
2019
93
1.770
Why?
Cholangitis, Sclerosing
3
2023
66
1.500
Why?
Proto-Oncogene Proteins c-akt
6
2016
397
1.470
Why?
Oxidative Stress
14
2019
1068
1.350
Why?
Fatty Liver
3
2014
209
1.130
Why?
Inflammatory Bowel Diseases
3
2020
284
1.030
Why?
Fatty Liver, Alcoholic
2
2016
14
0.960
Why?
Carcinoma, Hepatocellular
3
2019
210
0.920
Why?
Thioredoxins
3
2018
33
0.890
Why?
Mice
34
2023
14843
0.880
Why?
AMP-Activated Protein Kinases
2
2014
170
0.800
Why?
Abdominal Injuries
1
2023
107
0.800
Why?
Protein Processing, Post-Translational
4
2016
399
0.750
Why?
Butylated Hydroxytoluene
2
2011
31
0.680
Why?
Animals
36
2023
31565
0.660
Why?
Hepatocytes
5
2021
195
0.650
Why?
Bile Acids and Salts
5
2023
171
0.650
Why?
Peroxiredoxins
2
2018
23
0.640
Why?
Liver Neoplasms
4
2019
504
0.640
Why?
NF-E2-Related Factor 2
2
2019
71
0.620
Why?
Thioredoxin-Disulfide Reductase
1
2018
14
0.610
Why?
Parenteral Nutrition
4
2023
96
0.600
Why?
Non-alcoholic Fatty Liver Disease
3
2017
244
0.590
Why?
Gene Knockout Techniques
1
2018
98
0.590
Why?
Liver Diseases
2
2021
254
0.580
Why?
Hepatitis
1
2017
45
0.570
Why?
Superoxide Dismutase
5
2019
305
0.550
Why?
Mitochondrial Proteins
2
2015
213
0.550
Why?
End Stage Liver Disease
1
2017
61
0.540
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
9
0.530
Why?
Thioredoxin Reductase 1
3
2023
8
0.520
Why?
Tandem Mass Spectrometry
5
2022
410
0.510
Why?
Liver Cirrhosis, Alcoholic
1
2015
17
0.510
Why?
Signal Transduction
9
2021
4501
0.500
Why?
Mice, Inbred C57BL
14
2021
4680
0.490
Why?
Alcoholism
3
2018
710
0.480
Why?
Mice, Knockout
8
2020
2562
0.460
Why?
Oxidants
2
2012
112
0.450
Why?
Diet, High-Fat
2
2016
225
0.440
Why?
Disease Models, Animal
10
2021
3498
0.430
Why?
Dietary Fats
2
2018
287
0.400
Why?
RNA, Messenger
6
2023
2550
0.390
Why?
Male
27
2022
55396
0.380
Why?
Lipid Peroxidation
4
2016
139
0.380
Why?
Xenobiotics
1
2011
24
0.370
Why?
Liver Cirrhosis
2
2023
227
0.360
Why?
Chromatography, Liquid
4
2017
345
0.360
Why?
Cell Proliferation
3
2018
2173
0.360
Why?
Hydrogen Peroxide
1
2012
288
0.350
Why?
Alcohol Drinking
1
2016
650
0.350
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
20
0.350
Why?
Mitochondria
4
2019
744
0.340
Why?
Receptors, Cytoplasmic and Nuclear
2
2021
192
0.340
Why?
Tumor Necrosis Factor-alpha
4
2023
1128
0.340
Why?
Glutathione Reductase
3
2019
21
0.340
Why?
Inflammation
5
2023
2464
0.340
Why?
Down-Regulation
1
2011
594
0.310
Why?
Carcinoma
1
2010
198
0.310
Why?
Autophagy
2
2022
235
0.300
Why?
Blotting, Western
4
2016
1143
0.300
Why?
Alcohol Oxidoreductases
1
2008
37
0.300
Why?
Colonic Neoplasms
1
2010
212
0.300
Why?
Carcinogens
1
2008
102
0.290
Why?
Catalase
2
2017
118
0.290
Why?
Phosphoric Monoester Hydrolases
1
2007
54
0.270
Why?
NF-kappa B
2
2021
636
0.270
Why?
Glutathione
4
2019
293
0.260
Why?
Case-Control Studies
3
2018
3003
0.260
Why?
Humans
27
2023
114045
0.260
Why?
Hep G2 Cells
3
2021
59
0.250
Why?
Alanine Transaminase
3
2016
141
0.250
Why?
Biomarkers
1
2015
3397
0.250
Why?
Up-Regulation
2
2019
802
0.250
Why?
Protein Kinase Inhibitors
1
2011
784
0.250
Why?
Gene Expression Regulation
5
2021
2322
0.250
Why?
Proteomics
4
2019
815
0.240
Why?
Recombinant Proteins
4
2020
1228
0.240
Why?
Enzyme Inhibitors
1
2008
743
0.240
Why?
Macrophage Activation
2
2023
163
0.240
Why?
Epithelial Cells
1
2010
946
0.230
Why?
Phosphorylation
3
2014
1558
0.230
Why?
Lipoproteins
2
2021
159
0.220
Why?
ARNTL Transcription Factors
1
2023
13
0.220
Why?
Genes, Regulator
1
2023
34
0.220
Why?
Cysteine Proteinase Inhibitors
2
2014
45
0.210
Why?
Prostatic Neoplasms
1
2010
913
0.210
Why?
Insulin Resistance
1
2011
1072
0.210
Why?
Sulfhydryl Compounds
2
2018
176
0.210
Why?
Triglycerides
2
2016
467
0.200
Why?
Fatty Acid-Binding Proteins
2
2013
60
0.200
Why?
Enzyme Activation
3
2013
771
0.200
Why?
Mitochondria, Liver
2
2013
67
0.200
Why?
Dioxanes
1
2021
5
0.190
Why?
Oxidation-Reduction
3
2019
917
0.190
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
144
0.190
Why?
Isoxazoles
1
2021
51
0.190
Why?
Phytosterols
1
2021
11
0.190
Why?
Models, Molecular
4
2014
1368
0.180
Why?
Cholesterol
2
2020
368
0.180
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
24
0.180
Why?
Mucoproteins
1
2020
10
0.180
Why?
Phosphatidylcholines
1
2020
132
0.170
Why?
Vesicular Transport Proteins
1
2020
82
0.170
Why?
Gene Expression
2
2021
1417
0.170
Why?
Liposomes
1
2020
146
0.170
Why?
Cell Adhesion Molecules
1
2020
167
0.170
Why?
Chromatography, High Pressure Liquid
2
2013
465
0.160
Why?
Female
9
2021
59324
0.160
Why?
Acylation
1
2019
28
0.160
Why?
Lysosomes
1
2019
123
0.160
Why?
Lung
1
2011
3521
0.160
Why?
Colon
1
2020
232
0.160
Why?
PPAR alpha
2
2016
52
0.150
Why?
Ribosomes
1
2019
148
0.150
Why?
Mice, 129 Strain
1
2018
77
0.150
Why?
Reactive Oxygen Species
2
2011
522
0.150
Why?
Heme Oxygenase-1
1
2018
51
0.150
Why?
Sulfinic Acids
1
2018
7
0.150
Why?
Colitis
1
2020
223
0.150
Why?
Pyruvaldehyde
1
2018
27
0.150
Why?
Aminobutyrates
1
2018
31
0.150
Why?
Middle Aged
4
2019
26605
0.150
Why?
Azo Compounds
1
2017
25
0.140
Why?
Taurine
1
2018
41
0.140
Why?
Organ Specificity
1
2018
266
0.140
Why?
HSP70 Heat-Shock Proteins
1
2017
61
0.140
Why?
Malnutrition
1
2018
62
0.140
Why?
Protein Structure, Secondary
1
2018
325
0.140
Why?
Cell Line, Tumor
3
2020
2700
0.140
Why?
Gene Deletion
2
2015
356
0.140
Why?
Homocystinuria
1
2018
62
0.140
Why?
Mice, Inbred BALB C
2
2011
1144
0.140
Why?
Adult
4
2019
30375
0.130
Why?
Amino Acid Sequence
4
2015
1981
0.130
Why?
Lipogenesis
1
2016
56
0.130
Why?
Fatty Acids, Unsaturated
1
2016
84
0.130
Why?
Sirtuin 3
2
2019
51
0.130
Why?
Lysine
1
2017
241
0.130
Why?
Proteome
1
2019
337
0.120
Why?
Acetylation
4
2017
209
0.120
Why?
Cytochrome P-450 CYP4A
1
2014
4
0.120
Why?
Protein Isoforms
1
2015
337
0.120
Why?
Protein Binding
4
2020
1888
0.110
Why?
CD36 Antigens
1
2014
36
0.110
Why?
Computational Biology
1
2017
528
0.110
Why?
Endoplasmic Reticulum Stress
1
2014
92
0.110
Why?
Heat-Shock Proteins
1
2014
112
0.110
Why?
Phosphatidylinositol 3-Kinases
2
2013
328
0.110
Why?
Carrier Proteins
1
2017
694
0.110
Why?
Central Nervous System Depressants
1
2014
80
0.110
Why?
Adenosine Triphosphatases
1
2014
152
0.110
Why?
DNA Primers
2
2012
508
0.110
Why?
Acetyl-CoA Carboxylase
1
2013
33
0.110
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
24
0.110
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
54
0.100
Why?
Molecular Sequence Data
3
2015
2783
0.100
Why?
Endoplasmic Reticulum
2
2014
234
0.100
Why?
Polymerase Chain Reaction
2
2016
990
0.100
Why?
Models, Chemical
1
2014
248
0.100
Why?
Organ Size
1
2013
434
0.100
Why?
Adiponectin
1
2013
213
0.090
Why?
Reactive Nitrogen Species
1
2011
21
0.090
Why?
Glycogen Synthase Kinase 3 beta
1
2011
60
0.090
Why?
Peptide Mapping
1
2011
60
0.090
Why?
Binding Sites
2
2020
1166
0.090
Why?
Glycogen Synthase Kinase 3
1
2011
77
0.090
Why?
Receptors, Estrogen
1
2013
371
0.090
Why?
Oxygen Consumption
1
2013
587
0.090
Why?
Crotonates
1
2010
3
0.090
Why?
Toluidines
1
2010
6
0.090
Why?
Hydroxybutyrates
1
2010
11
0.090
Why?
Tumor Cells, Cultured
1
2012
845
0.090
Why?
Fenretinide
1
2010
7
0.090
Why?
Cell Line, Transformed
1
2010
133
0.080
Why?
Microscopy, Confocal
1
2011
304
0.080
Why?
Fluorescence Resonance Energy Transfer
1
2011
167
0.080
Why?
Nitriles
1
2010
149
0.080
Why?
Protein Conformation
1
2012
803
0.080
Why?
Glycoproteins
1
2011
304
0.080
Why?
Cell Survival
1
2012
1014
0.080
Why?
Alkylation
1
2008
18
0.080
Why?
Nuclear Proteins
1
2013
591
0.080
Why?
Kidney
1
2015
1182
0.080
Why?
DNA Damage
2
2021
351
0.070
Why?
RNA, Small Interfering
1
2010
534
0.070
Why?
Cytosol
1
2008
201
0.070
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
161
0.070
Why?
Lung Neoplasms
2
2011
2159
0.070
Why?
Base Sequence
1
2011
2114
0.070
Why?
Cells, Cultured
2
2013
3861
0.070
Why?
Phosphatidylinositol Phosphates
1
2007
38
0.070
Why?
Immunohistochemistry
1
2011
1624
0.070
Why?
Static Electricity
1
2007
112
0.070
Why?
Hydrolysis
1
2007
173
0.070
Why?
Amino Acid Substitution
1
2007
261
0.070
Why?
Rats, Sprague-Dawley
1
2011
2182
0.060
Why?
Cloning, Molecular
2
2020
522
0.060
Why?
Peptides
1
2011
847
0.060
Why?
Skin
1
2010
653
0.060
Why?
Metabolome
2
2019
274
0.060
Why?
Phospholipids
1
2007
194
0.060
Why?
Transcription Factors
1
2013
1526
0.060
Why?
Biomarkers, Tumor
1
2011
1032
0.060
Why?
Glycosylation
2
2016
130
0.050
Why?
Amino Acids
2
2018
445
0.050
Why?
Rats
1
2011
4913
0.050
Why?
Sterols
1
2021
17
0.050
Why?
Multidrug Resistance-Associated Proteins
1
2021
34
0.050
Why?
Fatty Acids
2
2016
380
0.050
Why?
Systems Analysis
1
2021
21
0.050
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
99
0.050
Why?
Intestinal Diseases
1
2021
33
0.050
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
73
0.050
Why?
Bilirubin
1
2021
88
0.050
Why?
Infliximab
1
2021
93
0.050
Why?
Gas Chromatography-Mass Spectrometry
1
2021
121
0.050
Why?
Chromatin Immunoprecipitation
1
2021
128
0.050
Why?
Apoptosis
1
2010
2349
0.050
Why?
Calcium
1
2007
1089
0.050
Why?
Sphingomyelins
1
2020
26
0.050
Why?
Protein Conformation, beta-Strand
1
2020
15
0.050
Why?
Ursodeoxycholic Acid
1
2020
20
0.040
Why?
Phosphatidylinositols
1
2020
53
0.040
Why?
Phosphatidylethanolamines
1
2020
66
0.040
Why?
Dextran Sulfate
1
2020
70
0.040
Why?
Molecular Docking Simulation
1
2020
101
0.040
Why?
Phosphatidylserines
1
2020
87
0.040
Why?
Gene Knockdown Techniques
1
2021
301
0.040
Why?
Protein Interaction Domains and Motifs
1
2020
129
0.040
Why?
Lipid Bilayers
1
2020
94
0.040
Why?
Aged
1
2017
18969
0.040
Why?
Genetic Vectors
1
2020
287
0.040
Why?
Interleukin-1beta
1
2021
368
0.040
Why?
Crystallography, X-Ray
1
2020
402
0.040
Why?
Molecular Dynamics Simulation
1
2020
200
0.040
Why?
Sirtuins
1
2019
32
0.040
Why?
Disease Susceptibility
1
2020
316
0.040
Why?
gamma-Glutamyltransferase
1
2018
42
0.040
Why?
Metabolic Networks and Pathways
1
2019
167
0.040
Why?
Cystathionine beta-Synthase
1
2018
59
0.040
Why?
Escherichia coli
1
2020
723
0.030
Why?
Insulin-Secreting Cells
1
2020
317
0.030
Why?
F2-Isoprostanes
1
2016
14
0.030
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.030
Why?
Mutation
1
2007
3338
0.030
Why?
Sumoylation
1
2016
15
0.030
Why?
Oxides
1
2016
40
0.030
Why?
Methylation
1
2016
208
0.030
Why?
Chemokine CXCL2
1
2014
41
0.030
Why?
Macrophages
1
2021
1259
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
25
0.030
Why?
Oxidative Phosphorylation
1
2015
154
0.030
Why?
Lipopolysaccharide Receptors
1
2014
81
0.030
Why?
Unfolded Protein Response
1
2014
44
0.030
Why?
Matrix Metalloproteinases
1
2014
89
0.030
Why?
Protein Folding
1
2014
239
0.030
Why?
Antibodies
1
2014
365
0.030
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
126
0.030
Why?
Actins
1
2014
376
0.030
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.030
Why?
Fibrosis
1
2014
452
0.030
Why?
Lipid Metabolism
1
2015
441
0.030
Why?
Disease Progression
1
2019
2371
0.020
Why?
Transforming Growth Factor beta
1
2014
445
0.020
Why?
Ubiquitination
1
2012
86
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2013
270
0.020
Why?
Immunoprecipitation
1
2012
151
0.020
Why?
Protein Structure, Tertiary
1
2014
796
0.020
Why?
Transcriptome
1
2016
723
0.020
Why?
Microsomes, Liver
1
2011
54
0.020
Why?
NAD
1
2011
63
0.020
Why?
Sequence Alignment
1
2011
323
0.020
Why?
Hypoxia
1
2016
956
0.020
Why?
Computer Simulation
1
2014
873
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
924
0.020
Why?
Lipids
1
2013
564
0.020
Why?
Mass Spectrometry
1
2012
622
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1145
0.020
Why?
Mice, Transgenic
1
2013
1947
0.020
Why?
Cytokines
1
2014
1824
0.020
Why?
Genetic Predisposition to Disease
1
2013
2090
0.010
Why?
Adolescent
1
2016
17800
0.010
Why?
Child
1
2016
18401
0.010
Why?
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