Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Colin Shearn

Concepts (291)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Cholestasis
10
2023
224
3.850
Why?
Aldehydes
15
2022
142
3.550
Why?
PTEN Phosphohydrolase
7
2018
140
2.790
Why?
Protein Carbonylation
10
2018
51
2.770
Why?
Liver Diseases, Alcoholic
12
2019
84
2.720
Why?
Liver
19
2022
1681
2.580
Why?
Ethanol
12
2019
548
2.030
Why?
Antioxidants
7
2023
530
1.820
Why?
Glutathione Transferase
8
2019
95
1.800
Why?
Cholangitis, Sclerosing
3
2023
70
1.520
Why?
Proto-Oncogene Proteins c-akt
6
2016
400
1.500
Why?
Oxidative Stress
14
2019
1085
1.370
Why?
Fatty Liver
3
2014
217
1.150
Why?
Inflammatory Bowel Diseases
3
2020
288
1.040
Why?
Fatty Liver, Alcoholic
2
2016
16
0.980
Why?
Carcinoma, Hepatocellular
3
2019
218
0.930
Why?
Thioredoxins
3
2018
33
0.900
Why?
Mice
34
2023
14928
0.890
Why?
Abdominal Injuries
1
2023
95
0.820
Why?
AMP-Activated Protein Kinases
2
2014
175
0.810
Why?
Protein Processing, Post-Translational
4
2016
399
0.760
Why?
Butylated Hydroxytoluene
2
2011
32
0.690
Why?
Animals
36
2023
31868
0.670
Why?
Hepatocytes
5
2021
196
0.660
Why?
Bile Acids and Salts
5
2023
172
0.660
Why?
Peroxiredoxins
2
2018
23
0.650
Why?
Liver Neoplasms
4
2019
516
0.640
Why?
NF-E2-Related Factor 2
2
2019
71
0.630
Why?
Thioredoxin-Disulfide Reductase
1
2018
14
0.620
Why?
Parenteral Nutrition
4
2023
93
0.610
Why?
Non-alcoholic Fatty Liver Disease
3
2017
246
0.600
Why?
Gene Knockout Techniques
1
2018
99
0.600
Why?
Liver Diseases
2
2021
259
0.590
Why?
Hepatitis
1
2017
45
0.580
Why?
Superoxide Dismutase
5
2019
305
0.560
Why?
Mitochondrial Proteins
2
2015
220
0.560
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
9
0.540
Why?
End Stage Liver Disease
1
2017
73
0.540
Why?
Thioredoxin Reductase 1
3
2023
8
0.530
Why?
Tandem Mass Spectrometry
5
2022
413
0.520
Why?
Liver Cirrhosis, Alcoholic
1
2015
18
0.520
Why?
Signal Transduction
9
2021
4525
0.500
Why?
Mice, Inbred C57BL
14
2021
4718
0.500
Why?
Alcoholism
3
2018
716
0.480
Why?
Mice, Knockout
8
2020
2585
0.460
Why?
Oxidants
2
2012
112
0.460
Why?
Diet, High-Fat
2
2016
225
0.450
Why?
Disease Models, Animal
10
2021
3545
0.430
Why?
Dietary Fats
2
2018
290
0.400
Why?
RNA, Messenger
6
2023
2563
0.400
Why?
Lipid Peroxidation
4
2016
139
0.390
Why?
Male
27
2022
55735
0.390
Why?
Xenobiotics
1
2011
24
0.370
Why?
Liver Cirrhosis
2
2023
235
0.370
Why?
Chromatography, Liquid
4
2017
348
0.360
Why?
Hydrogen Peroxide
1
2012
287
0.360
Why?
Cell Proliferation
3
2018
2191
0.360
Why?
Alcohol Drinking
1
2016
655
0.350
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
20
0.350
Why?
Mitochondria
4
2019
750
0.350
Why?
Receptors, Cytoplasmic and Nuclear
2
2021
193
0.350
Why?
Glutathione Reductase
3
2019
21
0.340
Why?
Tumor Necrosis Factor-alpha
4
2023
1138
0.340
Why?
Inflammation
5
2023
2485
0.340
Why?
Down-Regulation
1
2011
599
0.320
Why?
Carcinoma
1
2010
199
0.310
Why?
Autophagy
2
2022
234
0.310
Why?
Blotting, Western
4
2016
1149
0.310
Why?
Alcohol Oxidoreductases
1
2008
38
0.310
Why?
Colonic Neoplasms
1
2010
222
0.300
Why?
Carcinogens
1
2008
105
0.300
Why?
Catalase
2
2017
117
0.290
Why?
Phosphoric Monoester Hydrolases
1
2007
54
0.280
Why?
NF-kappa B
2
2021
637
0.270
Why?
Glutathione
4
2019
302
0.270
Why?
Case-Control Studies
3
2018
3015
0.260
Why?
Humans
27
2023
115049
0.260
Why?
Hep G2 Cells
3
2021
61
0.260
Why?
Alanine Transaminase
3
2016
140
0.260
Why?
Biomarkers
1
2015
3419
0.250
Why?
Up-Regulation
2
2019
812
0.250
Why?
Protein Kinase Inhibitors
1
2011
788
0.250
Why?
Gene Expression Regulation
5
2021
2329
0.250
Why?
Recombinant Proteins
4
2020
1237
0.250
Why?
Proteomics
4
2019
844
0.250
Why?
Enzyme Inhibitors
1
2008
752
0.240
Why?
Macrophage Activation
2
2023
164
0.240
Why?
Epithelial Cells
1
2010
956
0.230
Why?
Phosphorylation
3
2014
1572
0.230
Why?
Lipoproteins
2
2021
160
0.230
Why?
ARNTL Transcription Factors
1
2023
13
0.220
Why?
Genes, Regulator
1
2023
34
0.220
Why?
Cysteine Proteinase Inhibitors
2
2014
45
0.220
Why?
Prostatic Neoplasms
1
2010
921
0.210
Why?
Insulin Resistance
1
2011
1077
0.210
Why?
Sulfhydryl Compounds
2
2018
177
0.210
Why?
Triglycerides
2
2016
471
0.210
Why?
Fatty Acid-Binding Proteins
2
2013
61
0.200
Why?
Mitochondria, Liver
2
2013
66
0.200
Why?
Enzyme Activation
3
2013
791
0.200
Why?
Dioxanes
1
2021
7
0.200
Why?
Oxidation-Reduction
3
2019
926
0.190
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
144
0.190
Why?
Isoxazoles
1
2021
52
0.190
Why?
Phytosterols
1
2021
11
0.190
Why?
Models, Molecular
4
2014
1379
0.190
Why?
Cholesterol
2
2020
368
0.180
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
24
0.180
Why?
Mucoproteins
1
2020
10
0.180
Why?
Phosphatidylcholines
1
2020
133
0.170
Why?
Vesicular Transport Proteins
1
2020
83
0.170
Why?
Liposomes
1
2020
146
0.170
Why?
Gene Expression
2
2021
1423
0.170
Why?
Cell Adhesion Molecules
1
2020
168
0.170
Why?
Chromatography, High Pressure Liquid
2
2013
474
0.170
Why?
Acylation
1
2019
28
0.160
Why?
Female
9
2021
59617
0.160
Why?
Lysosomes
1
2019
123
0.160
Why?
Colon
1
2020
233
0.160
Why?
Lung
1
2011
3595
0.160
Why?
PPAR alpha
2
2016
52
0.160
Why?
Ribosomes
1
2019
148
0.150
Why?
Mice, 129 Strain
1
2018
76
0.150
Why?
Heme Oxygenase-1
1
2018
52
0.150
Why?
Reactive Oxygen Species
2
2011
536
0.150
Why?
Sulfinic Acids
1
2018
7
0.150
Why?
Colitis
1
2020
226
0.150
Why?
Pyruvaldehyde
1
2018
27
0.150
Why?
Aminobutyrates
1
2018
32
0.150
Why?
Azo Compounds
1
2017
25
0.150
Why?
Middle Aged
4
2019
26830
0.150
Why?
Organ Specificity
1
2018
270
0.150
Why?
Taurine
1
2018
41
0.150
Why?
HSP70 Heat-Shock Proteins
1
2017
61
0.140
Why?
Malnutrition
1
2018
61
0.140
Why?
Protein Structure, Secondary
1
2018
325
0.140
Why?
Homocystinuria
1
2018
62
0.140
Why?
Gene Deletion
2
2015
356
0.140
Why?
Cell Line, Tumor
3
2020
2716
0.140
Why?
Mice, Inbred BALB C
2
2011
1153
0.140
Why?
Amino Acid Sequence
4
2015
1990
0.130
Why?
Adult
4
2019
30658
0.130
Why?
Lipogenesis
1
2016
57
0.130
Why?
Fatty Acids, Unsaturated
1
2016
85
0.130
Why?
Sirtuin 3
2
2019
52
0.130
Why?
Lysine
1
2017
242
0.130
Why?
Proteome
1
2019
339
0.130
Why?
Acetylation
4
2017
211
0.120
Why?
Cytochrome P-450 CYP4A
1
2014
4
0.120
Why?
Protein Isoforms
1
2015
339
0.120
Why?
CD36 Antigens
1
2014
37
0.120
Why?
Protein Binding
4
2020
1898
0.120
Why?
Endoplasmic Reticulum Stress
1
2014
91
0.110
Why?
Heat-Shock Proteins
1
2014
113
0.110
Why?
Computational Biology
1
2017
533
0.110
Why?
Phosphatidylinositol 3-Kinases
2
2013
331
0.110
Why?
Central Nervous System Depressants
1
2014
82
0.110
Why?
Carrier Proteins
1
2017
696
0.110
Why?
Adenosine Triphosphatases
1
2014
155
0.110
Why?
DNA Primers
2
2012
514
0.110
Why?
Acetyl-CoA Carboxylase
1
2013
33
0.110
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
24
0.110
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
54
0.110
Why?
Molecular Sequence Data
3
2015
2796
0.110
Why?
Endoplasmic Reticulum
2
2014
234
0.110
Why?
Polymerase Chain Reaction
2
2016
999
0.100
Why?
Models, Chemical
1
2014
250
0.100
Why?
Organ Size
1
2013
444
0.100
Why?
Adiponectin
1
2013
212
0.100
Why?
Reactive Nitrogen Species
1
2011
21
0.090
Why?
Glycogen Synthase Kinase 3 beta
1
2011
61
0.090
Why?
Peptide Mapping
1
2011
60
0.090
Why?
Binding Sites
2
2020
1173
0.090
Why?
Glycogen Synthase Kinase 3
1
2011
78
0.090
Why?
Receptors, Estrogen
1
2013
372
0.090
Why?
Oxygen Consumption
1
2013
588
0.090
Why?
Crotonates
1
2010
3
0.090
Why?
Toluidines
1
2010
6
0.090
Why?
Hydroxybutyrates
1
2010
10
0.090
Why?
Fenretinide
1
2010
7
0.090
Why?
Tumor Cells, Cultured
1
2012
851
0.090
Why?
Cell Line, Transformed
1
2010
133
0.090
Why?
Microscopy, Confocal
1
2011
305
0.090
Why?
Fluorescence Resonance Energy Transfer
1
2011
171
0.080
Why?
Nitriles
1
2010
152
0.080
Why?
Protein Conformation
1
2012
811
0.080
Why?
Glycoproteins
1
2011
305
0.080
Why?
Cell Survival
1
2012
1022
0.080
Why?
Alkylation
1
2008
18
0.080
Why?
Nuclear Proteins
1
2013
593
0.080
Why?
Kidney
1
2015
1186
0.080
Why?
DNA Damage
2
2021
357
0.080
Why?
RNA, Small Interfering
1
2010
541
0.070
Why?
Cytosol
1
2008
208
0.070
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
162
0.070
Why?
Base Sequence
1
2011
2119
0.070
Why?
Cells, Cultured
2
2013
3896
0.070
Why?
Lung Neoplasms
2
2011
2201
0.070
Why?
Phosphatidylinositol Phosphates
1
2007
38
0.070
Why?
Static Electricity
1
2007
114
0.070
Why?
Immunohistochemistry
1
2011
1634
0.070
Why?
Hydrolysis
1
2007
174
0.070
Why?
Amino Acid Substitution
1
2007
262
0.070
Why?
Cloning, Molecular
2
2020
524
0.070
Why?
Rats, Sprague-Dawley
1
2011
2212
0.070
Why?
Peptides
1
2011
849
0.060
Why?
Skin
1
2010
659
0.060
Why?
Metabolome
2
2019
285
0.060
Why?
Phospholipids
1
2007
199
0.060
Why?
Transcription Factors
1
2013
1531
0.060
Why?
Biomarkers, Tumor
1
2011
1045
0.060
Why?
Glycosylation
2
2016
131
0.060
Why?
Amino Acids
2
2018
451
0.050
Why?
Rats
1
2011
4973
0.050
Why?
Sterols
1
2021
17
0.050
Why?
Multidrug Resistance-Associated Proteins
1
2021
35
0.050
Why?
Fatty Acids
2
2016
385
0.050
Why?
Systems Analysis
1
2021
22
0.050
Why?
Intestinal Diseases
1
2021
29
0.050
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
101
0.050
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
72
0.050
Why?
Bilirubin
1
2021
88
0.050
Why?
Infliximab
1
2021
94
0.050
Why?
Gas Chromatography-Mass Spectrometry
1
2021
125
0.050
Why?
Chromatin Immunoprecipitation
1
2021
128
0.050
Why?
Calcium
1
2007
1104
0.050
Why?
Apoptosis
1
2010
2366
0.050
Why?
Protein Conformation, beta-Strand
1
2020
15
0.050
Why?
Sphingomyelins
1
2020
27
0.050
Why?
Ursodeoxycholic Acid
1
2020
21
0.050
Why?
Phosphatidylinositols
1
2020
53
0.050
Why?
Phosphatidylethanolamines
1
2020
66
0.050
Why?
Dextran Sulfate
1
2020
70
0.040
Why?
Molecular Docking Simulation
1
2020
102
0.040
Why?
Phosphatidylserines
1
2020
87
0.040
Why?
Gene Knockdown Techniques
1
2021
299
0.040
Why?
Protein Interaction Domains and Motifs
1
2020
132
0.040
Why?
Lipid Bilayers
1
2020
99
0.040
Why?
Genetic Vectors
1
2020
291
0.040
Why?
Aged
1
2017
19122
0.040
Why?
Interleukin-1beta
1
2021
370
0.040
Why?
Crystallography, X-Ray
1
2020
405
0.040
Why?
Molecular Dynamics Simulation
1
2020
201
0.040
Why?
Sirtuins
1
2019
32
0.040
Why?
Disease Susceptibility
1
2020
316
0.040
Why?
gamma-Glutamyltransferase
1
2018
42
0.040
Why?
Metabolic Networks and Pathways
1
2019
168
0.040
Why?
Cystathionine beta-Synthase
1
2018
59
0.040
Why?
Escherichia coli
1
2020
719
0.040
Why?
Insulin-Secreting Cells
1
2020
318
0.030
Why?
F2-Isoprostanes
1
2016
14
0.030
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.030
Why?
Sumoylation
1
2016
15
0.030
Why?
Mutation
1
2007
3350
0.030
Why?
Oxides
1
2016
43
0.030
Why?
Methylation
1
2016
208
0.030
Why?
Chemokine CXCL2
1
2014
37
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
25
0.030
Why?
Macrophages
1
2021
1267
0.030
Why?
Oxidative Phosphorylation
1
2015
156
0.030
Why?
Lipopolysaccharide Receptors
1
2014
81
0.030
Why?
Unfolded Protein Response
1
2014
43
0.030
Why?
Matrix Metalloproteinases
1
2014
89
0.030
Why?
Protein Folding
1
2014
239
0.030
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
127
0.030
Why?
Antibodies
1
2014
372
0.030
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.030
Why?
Actins
1
2014
383
0.030
Why?
Fibrosis
1
2014
454
0.030
Why?
Lipid Metabolism
1
2015
449
0.030
Why?
Disease Progression
1
2019
2389
0.030
Why?
Transforming Growth Factor beta
1
2014
448
0.030
Why?
Ubiquitination
1
2012
86
0.030
Why?
Gene Expression Regulation, Enzymologic
1
2013
271
0.020
Why?
Immunoprecipitation
1
2012
152
0.020
Why?
Protein Structure, Tertiary
1
2014
798
0.020
Why?
Transcriptome
1
2016
726
0.020
Why?
Microsomes, Liver
1
2011
56
0.020
Why?
NAD
1
2011
64
0.020
Why?
Sequence Alignment
1
2011
325
0.020
Why?
Hypoxia
1
2016
959
0.020
Why?
Computer Simulation
1
2014
881
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
928
0.020
Why?
Lipids
1
2013
586
0.020
Why?
Mass Spectrometry
1
2012
634
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1145
0.020
Why?
Mice, Transgenic
1
2013
1955
0.020
Why?
Cytokines
1
2014
1843
0.020
Why?
Genetic Predisposition to Disease
1
2013
2108
0.010
Why?
Adolescent
1
2016
17864
0.010
Why?
Child
1
2016
18407
0.010
Why?
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