Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Colin Shearn

Concepts (291)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Cholestasis
10
2023
225
3.830
Why?
Aldehydes
15
2022
138
3.530
Why?
PTEN Phosphohydrolase
7
2018
140
2.770
Why?
Protein Carbonylation
10
2018
51
2.750
Why?
Liver Diseases, Alcoholic
12
2019
81
2.710
Why?
Liver
19
2022
1634
2.580
Why?
Ethanol
12
2019
538
2.030
Why?
Antioxidants
7
2023
530
1.810
Why?
Glutathione Transferase
8
2019
93
1.790
Why?
Cholangitis, Sclerosing
3
2023
66
1.520
Why?
Proto-Oncogene Proteins c-akt
6
2016
398
1.490
Why?
Oxidative Stress
14
2019
1076
1.360
Why?
Fatty Liver
3
2014
210
1.140
Why?
Inflammatory Bowel Diseases
3
2020
284
1.030
Why?
Fatty Liver, Alcoholic
2
2016
14
0.970
Why?
Carcinoma, Hepatocellular
3
2019
211
0.920
Why?
Thioredoxins
3
2018
33
0.900
Why?
Mice
34
2023
14860
0.880
Why?
AMP-Activated Protein Kinases
2
2014
172
0.810
Why?
Abdominal Injuries
1
2023
108
0.800
Why?
Protein Processing, Post-Translational
4
2016
399
0.750
Why?
Butylated Hydroxytoluene
2
2011
31
0.680
Why?
Animals
36
2023
31694
0.670
Why?
Hepatocytes
5
2021
195
0.660
Why?
Bile Acids and Salts
5
2023
171
0.650
Why?
Peroxiredoxins
2
2018
23
0.650
Why?
Liver Neoplasms
4
2019
506
0.640
Why?
NF-E2-Related Factor 2
2
2019
71
0.630
Why?
Thioredoxin-Disulfide Reductase
1
2018
14
0.620
Why?
Parenteral Nutrition
4
2023
96
0.610
Why?
Non-alcoholic Fatty Liver Disease
3
2017
245
0.600
Why?
Gene Knockout Techniques
1
2018
98
0.600
Why?
Liver Diseases
2
2021
255
0.590
Why?
Hepatitis
1
2017
45
0.570
Why?
Superoxide Dismutase
5
2019
305
0.560
Why?
Mitochondrial Proteins
2
2015
219
0.560
Why?
End Stage Liver Disease
1
2017
63
0.540
Why?
Chemical and Drug Induced Liver Injury, Chronic
1
2016
9
0.530
Why?
Thioredoxin Reductase 1
3
2023
8
0.520
Why?
Tandem Mass Spectrometry
5
2022
411
0.520
Why?
Liver Cirrhosis, Alcoholic
1
2015
17
0.510
Why?
Signal Transduction
9
2021
4509
0.500
Why?
Mice, Inbred C57BL
14
2021
4689
0.500
Why?
Alcoholism
3
2018
713
0.480
Why?
Mice, Knockout
8
2020
2565
0.460
Why?
Oxidants
2
2012
112
0.450
Why?
Diet, High-Fat
2
2016
225
0.450
Why?
Disease Models, Animal
10
2021
3531
0.430
Why?
Dietary Fats
2
2018
287
0.400
Why?
RNA, Messenger
6
2023
2552
0.400
Why?
Lipid Peroxidation
4
2016
139
0.390
Why?
Male
27
2022
55554
0.390
Why?
Xenobiotics
1
2011
24
0.370
Why?
Liver Cirrhosis
2
2023
227
0.370
Why?
Chromatography, Liquid
4
2017
347
0.360
Why?
Hydrogen Peroxide
1
2012
288
0.360
Why?
Cell Proliferation
3
2018
2186
0.360
Why?
Alcohol Drinking
1
2016
651
0.350
Why?
Oxidoreductases Acting on CH-CH Group Donors
1
2010
20
0.350
Why?
Mitochondria
4
2019
747
0.350
Why?
Receptors, Cytoplasmic and Nuclear
2
2021
192
0.340
Why?
Glutathione Reductase
3
2019
21
0.340
Why?
Tumor Necrosis Factor-alpha
4
2023
1139
0.340
Why?
Inflammation
5
2023
2477
0.340
Why?
Down-Regulation
1
2011
594
0.310
Why?
Carcinoma
1
2010
198
0.310
Why?
Autophagy
2
2022
233
0.310
Why?
Blotting, Western
4
2016
1147
0.310
Why?
Alcohol Oxidoreductases
1
2008
38
0.300
Why?
Colonic Neoplasms
1
2010
215
0.300
Why?
Carcinogens
1
2008
103
0.300
Why?
Catalase
2
2017
118
0.290
Why?
Phosphoric Monoester Hydrolases
1
2007
54
0.270
Why?
NF-kappa B
2
2021
638
0.270
Why?
Glutathione
4
2019
293
0.270
Why?
Case-Control Studies
3
2018
3003
0.260
Why?
Humans
27
2023
114623
0.260
Why?
Hep G2 Cells
3
2021
60
0.260
Why?
Alanine Transaminase
3
2016
141
0.260
Why?
Biomarkers
1
2015
3408
0.250
Why?
Up-Regulation
2
2019
807
0.250
Why?
Protein Kinase Inhibitors
1
2011
785
0.250
Why?
Gene Expression Regulation
5
2021
2319
0.250
Why?
Recombinant Proteins
4
2020
1230
0.250
Why?
Proteomics
4
2019
836
0.240
Why?
Enzyme Inhibitors
1
2008
750
0.240
Why?
Macrophage Activation
2
2023
164
0.240
Why?
Epithelial Cells
1
2010
950
0.230
Why?
Phosphorylation
3
2014
1569
0.230
Why?
Lipoproteins
2
2021
159
0.220
Why?
ARNTL Transcription Factors
1
2023
13
0.220
Why?
Genes, Regulator
1
2023
34
0.220
Why?
Cysteine Proteinase Inhibitors
2
2014
45
0.220
Why?
Prostatic Neoplasms
1
2010
921
0.210
Why?
Insulin Resistance
1
2011
1072
0.210
Why?
Sulfhydryl Compounds
2
2018
177
0.210
Why?
Triglycerides
2
2016
467
0.200
Why?
Fatty Acid-Binding Proteins
2
2013
60
0.200
Why?
Enzyme Activation
3
2013
785
0.200
Why?
Mitochondria, Liver
2
2013
67
0.200
Why?
Dioxanes
1
2021
5
0.200
Why?
Oxidation-Reduction
3
2019
923
0.190
Why?
NLR Family, Pyrin Domain-Containing 3 Protein
1
2023
144
0.190
Why?
Isoxazoles
1
2021
51
0.190
Why?
Phytosterols
1
2021
11
0.190
Why?
Models, Molecular
4
2014
1369
0.190
Why?
Cholesterol
2
2020
367
0.180
Why?
Phosphatidylinositol 4,5-Diphosphate
1
2020
24
0.180
Why?
Mucoproteins
1
2020
10
0.180
Why?
Phosphatidylcholines
1
2020
133
0.170
Why?
Vesicular Transport Proteins
1
2020
83
0.170
Why?
Liposomes
1
2020
146
0.170
Why?
Gene Expression
2
2021
1421
0.170
Why?
Cell Adhesion Molecules
1
2020
168
0.170
Why?
Chromatography, High Pressure Liquid
2
2013
470
0.160
Why?
Acylation
1
2019
28
0.160
Why?
Female
9
2021
59466
0.160
Why?
Lysosomes
1
2019
123
0.160
Why?
Lung
1
2011
3558
0.160
Why?
Colon
1
2020
233
0.160
Why?
PPAR alpha
2
2016
52
0.150
Why?
Ribosomes
1
2019
148
0.150
Why?
Mice, 129 Strain
1
2018
75
0.150
Why?
Heme Oxygenase-1
1
2018
52
0.150
Why?
Reactive Oxygen Species
2
2011
531
0.150
Why?
Sulfinic Acids
1
2018
7
0.150
Why?
Colitis
1
2020
223
0.150
Why?
Pyruvaldehyde
1
2018
27
0.150
Why?
Aminobutyrates
1
2018
31
0.150
Why?
Azo Compounds
1
2017
25
0.150
Why?
Middle Aged
4
2019
26719
0.150
Why?
Taurine
1
2018
41
0.150
Why?
Organ Specificity
1
2018
268
0.140
Why?
HSP70 Heat-Shock Proteins
1
2017
61
0.140
Why?
Malnutrition
1
2018
62
0.140
Why?
Protein Structure, Secondary
1
2018
325
0.140
Why?
Homocystinuria
1
2018
62
0.140
Why?
Gene Deletion
2
2015
356
0.140
Why?
Cell Line, Tumor
3
2020
2710
0.140
Why?
Mice, Inbred BALB C
2
2011
1143
0.140
Why?
Adult
4
2019
30528
0.130
Why?
Amino Acid Sequence
4
2015
1982
0.130
Why?
Lipogenesis
1
2016
56
0.130
Why?
Fatty Acids, Unsaturated
1
2016
84
0.130
Why?
Sirtuin 3
2
2019
52
0.130
Why?
Lysine
1
2017
242
0.130
Why?
Proteome
1
2019
339
0.120
Why?
Acetylation
4
2017
211
0.120
Why?
Cytochrome P-450 CYP4A
1
2014
4
0.120
Why?
Protein Isoforms
1
2015
338
0.120
Why?
Protein Binding
4
2020
1889
0.120
Why?
CD36 Antigens
1
2014
37
0.120
Why?
Endoplasmic Reticulum Stress
1
2014
91
0.110
Why?
Computational Biology
1
2017
530
0.110
Why?
Heat-Shock Proteins
1
2014
113
0.110
Why?
Phosphatidylinositol 3-Kinases
2
2013
329
0.110
Why?
Central Nervous System Depressants
1
2014
81
0.110
Why?
Carrier Proteins
1
2017
695
0.110
Why?
Adenosine Triphosphatases
1
2014
153
0.110
Why?
DNA Primers
2
2012
510
0.110
Why?
Acetyl-CoA Carboxylase
1
2013
33
0.110
Why?
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
1
2013
24
0.110
Why?
Sterol Regulatory Element Binding Protein 1
1
2013
54
0.110
Why?
Molecular Sequence Data
3
2015
2785
0.110
Why?
Endoplasmic Reticulum
2
2014
234
0.100
Why?
Polymerase Chain Reaction
2
2016
993
0.100
Why?
Models, Chemical
1
2014
248
0.100
Why?
Organ Size
1
2013
434
0.100
Why?
Adiponectin
1
2013
213
0.090
Why?
Reactive Nitrogen Species
1
2011
21
0.090
Why?
Glycogen Synthase Kinase 3 beta
1
2011
60
0.090
Why?
Peptide Mapping
1
2011
60
0.090
Why?
Binding Sites
2
2020
1168
0.090
Why?
Glycogen Synthase Kinase 3
1
2011
77
0.090
Why?
Receptors, Estrogen
1
2013
372
0.090
Why?
Oxygen Consumption
1
2013
588
0.090
Why?
Crotonates
1
2010
3
0.090
Why?
Toluidines
1
2010
6
0.090
Why?
Hydroxybutyrates
1
2010
11
0.090
Why?
Fenretinide
1
2010
7
0.090
Why?
Tumor Cells, Cultured
1
2012
849
0.090
Why?
Cell Line, Transformed
1
2010
133
0.090
Why?
Microscopy, Confocal
1
2011
304
0.090
Why?
Fluorescence Resonance Energy Transfer
1
2011
170
0.080
Why?
Nitriles
1
2010
149
0.080
Why?
Protein Conformation
1
2012
805
0.080
Why?
Glycoproteins
1
2011
304
0.080
Why?
Cell Survival
1
2012
1020
0.080
Why?
Alkylation
1
2008
18
0.080
Why?
Nuclear Proteins
1
2013
591
0.080
Why?
Kidney
1
2015
1188
0.080
Why?
DNA Damage
2
2021
351
0.080
Why?
RNA, Small Interfering
1
2010
535
0.070
Why?
Cytosol
1
2008
208
0.070
Why?
Spectrometry, Mass, Electrospray Ionization
1
2008
162
0.070
Why?
Lung Neoplasms
2
2011
2177
0.070
Why?
Base Sequence
1
2011
2114
0.070
Why?
Cells, Cultured
2
2013
3881
0.070
Why?
Phosphatidylinositol Phosphates
1
2007
38
0.070
Why?
Static Electricity
1
2007
114
0.070
Why?
Immunohistochemistry
1
2011
1629
0.070
Why?
Hydrolysis
1
2007
173
0.070
Why?
Amino Acid Substitution
1
2007
262
0.070
Why?
Cloning, Molecular
2
2020
522
0.070
Why?
Rats, Sprague-Dawley
1
2011
2218
0.060
Why?
Peptides
1
2011
848
0.060
Why?
Skin
1
2010
655
0.060
Why?
Metabolome
2
2019
282
0.060
Why?
Phospholipids
1
2007
197
0.060
Why?
Transcription Factors
1
2013
1528
0.060
Why?
Biomarkers, Tumor
1
2011
1040
0.060
Why?
Glycosylation
2
2016
130
0.060
Why?
Amino Acids
2
2018
448
0.050
Why?
Rats
1
2011
4958
0.050
Why?
Sterols
1
2021
17
0.050
Why?
Multidrug Resistance-Associated Proteins
1
2021
34
0.050
Why?
Fatty Acids
2
2016
381
0.050
Why?
Systems Analysis
1
2021
21
0.050
Why?
Electrophoresis, Gel, Two-Dimensional
2
2012
100
0.050
Why?
Intestinal Diseases
1
2021
33
0.050
Why?
Receptors, Tumor Necrosis Factor, Type I
1
2021
73
0.050
Why?
Bilirubin
1
2021
88
0.050
Why?
Infliximab
1
2021
94
0.050
Why?
Gas Chromatography-Mass Spectrometry
1
2021
124
0.050
Why?
Chromatin Immunoprecipitation
1
2021
128
0.050
Why?
Calcium
1
2007
1104
0.050
Why?
Apoptosis
1
2010
2362
0.050
Why?
Sphingomyelins
1
2020
26
0.050
Why?
Protein Conformation, beta-Strand
1
2020
15
0.050
Why?
Ursodeoxycholic Acid
1
2020
20
0.050
Why?
Phosphatidylinositols
1
2020
54
0.050
Why?
Phosphatidylethanolamines
1
2020
66
0.040
Why?
Dextran Sulfate
1
2020
70
0.040
Why?
Molecular Docking Simulation
1
2020
101
0.040
Why?
Phosphatidylserines
1
2020
87
0.040
Why?
Gene Knockdown Techniques
1
2021
299
0.040
Why?
Protein Interaction Domains and Motifs
1
2020
129
0.040
Why?
Lipid Bilayers
1
2020
99
0.040
Why?
Genetic Vectors
1
2020
289
0.040
Why?
Aged
1
2017
19061
0.040
Why?
Interleukin-1beta
1
2021
370
0.040
Why?
Crystallography, X-Ray
1
2020
402
0.040
Why?
Molecular Dynamics Simulation
1
2020
201
0.040
Why?
Sirtuins
1
2019
32
0.040
Why?
Disease Susceptibility
1
2020
316
0.040
Why?
gamma-Glutamyltransferase
1
2018
42
0.040
Why?
Metabolic Networks and Pathways
1
2019
168
0.040
Why?
Cystathionine beta-Synthase
1
2018
59
0.040
Why?
Escherichia coli
1
2020
720
0.040
Why?
Insulin-Secreting Cells
1
2020
317
0.030
Why?
F2-Isoprostanes
1
2016
14
0.030
Why?
Protein D-Aspartate-L-Isoaspartate Methyltransferase
1
2016
5
0.030
Why?
Sumoylation
1
2016
15
0.030
Why?
Mutation
1
2007
3344
0.030
Why?
Oxides
1
2016
43
0.030
Why?
Methylation
1
2016
208
0.030
Why?
Chemokine CXCL2
1
2014
41
0.030
Why?
Macrophages
1
2021
1261
0.030
Why?
Receptor, Platelet-Derived Growth Factor beta
1
2014
25
0.030
Why?
Oxidative Phosphorylation
1
2015
155
0.030
Why?
Lipopolysaccharide Receptors
1
2014
81
0.030
Why?
Unfolded Protein Response
1
2014
43
0.030
Why?
Matrix Metalloproteinases
1
2014
89
0.030
Why?
Protein Folding
1
2014
239
0.030
Why?
Cyclic AMP Response Element-Binding Protein
1
2013
127
0.030
Why?
Antibodies
1
2014
371
0.030
Why?
Anilino Naphthalenesulfonates
1
2012
10
0.030
Why?
Actins
1
2014
381
0.030
Why?
Fibrosis
1
2014
453
0.030
Why?
Lipid Metabolism
1
2015
444
0.030
Why?
Disease Progression
1
2019
2380
0.030
Why?
Transforming Growth Factor beta
1
2014
448
0.020
Why?
Ubiquitination
1
2012
86
0.020
Why?
Gene Expression Regulation, Enzymologic
1
2013
270
0.020
Why?
Immunoprecipitation
1
2012
151
0.020
Why?
Protein Structure, Tertiary
1
2014
796
0.020
Why?
Transcriptome
1
2016
725
0.020
Why?
Microsomes, Liver
1
2011
55
0.020
Why?
NAD
1
2011
63
0.020
Why?
Sequence Alignment
1
2011
323
0.020
Why?
Hypoxia
1
2016
957
0.020
Why?
Computer Simulation
1
2014
872
0.020
Why?
Reverse Transcriptase Polymerase Chain Reaction
1
2012
923
0.020
Why?
Lipids
1
2013
580
0.020
Why?
Mass Spectrometry
1
2012
633
0.020
Why?
Gene Expression Regulation, Neoplastic
1
2013
1141
0.020
Why?
Mice, Transgenic
1
2013
1947
0.020
Why?
Cytokines
1
2014
1840
0.020
Why?
Genetic Predisposition to Disease
1
2013
2084
0.010
Why?
Adolescent
1
2016
17831
0.010
Why?
Child
1
2016
18404
0.010
Why?
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