 Proto-Oncogene Proteins c-rel
"Proto-Oncogene Proteins c-rel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.
| Descriptor ID |
D020569
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| MeSH Number(s) |
D12.776.260.682 D12.776.624.664.700.192 D12.776.660.767 D12.776.930.730
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| Concept/Terms |
Proto-Oncogene Proteins c-rel- Proto-Oncogene Proteins c-rel
- Proto Oncogene Proteins c rel
- c-rel, Proto-Oncogene Proteins
- p68 c-rel
- c-rel, p68
- p68 c rel
- Proto-Oncogene Protein c-rel
- Proto Oncogene Protein c rel
- c-rel, Proto-Oncogene Protein
- Proto-Oncogene Proteins rel
- Proto Oncogene Proteins rel
- c-rel Protein
- Protein, c-rel
- c rel Protein
- p68(c-rel)
- rel Proto-Oncogene Product p68
- rel Proto Oncogene Product p68
- Proto-Oncogene Products c-rel
- Proto Oncogene Products c rel
- c-rel, Proto-Oncogene Products
- c-rel Proteins
- Proteins, c-rel
- c rel Proteins
- rel Proto-Oncogene Proteins
- Proto-Oncogene Proteins, rel
- rel Proto Oncogene Proteins
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-rel".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-rel".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-rel" by people in this website by year, and whether "Proto-Oncogene Proteins c-rel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-rel" by people in Profiles.
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Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. PLoS One. 2013; 8(6):e67319.
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Hu CJ, Rao S, Ramirez-Bergeron DL, Garrett-Sinha LA, Gerondakis S, Clark MR, Simon MC. PU.1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity. 2001 Oct; 15(4):545-55.
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Bushdid PB, Brantley DM, Yull FE, Blaeuer GL, Hoffman LH, Niswander L, Kerr LD. Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis. Nature. 1998 Apr 09; 392(6676):615-8.
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Chu ZL, McKinsey TA, Liu L, Qi X, Ballard DW. Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product. Mol Cell Biol. 1996 Nov; 16(11):5974-84.
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Rottjakob EM, Sachdev S, Leanna CA, McKinsey TA, Hannink M. PEST-dependent cytoplasmic retention of v-Rel by I(kappa)B-alpha: evidence that I(kappa)B-alpha regulates cellular localization of c-Rel and v-Rel by distinct mechanisms. J Virol. 1996 May; 70(5):3176-88.
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Cogswell PC, Scheinman RI, Baldwin AS. Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL. J Immunol. 1993 Apr 01; 150(7):2794-804.
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Diehl JA, McKinsey TA, Hannink M. Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins. Mol Cell Biol. 1993 Mar; 13(3):1769-78.
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Beg AA, Ruben SM, Scheinman RI, Haskill S, Rosen CA, Baldwin AS. I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention. Genes Dev. 1992 Oct; 6(10):1899-913.
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