 KRIT1 Protein
"KRIT1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.
| Descriptor ID |
D000075927
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| MeSH Number(s) |
D12.776.220.600.450.458 D12.776.624.664.700.119 D12.776.631.560.465
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| Concept/Terms |
KRIT1 Protein- KRIT1 Protein
- Krev Interaction Trapped Protein 1
- Cerebral Cavernous Malformations 1 Protein
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Below are MeSH descriptors whose meaning is more general than "KRIT1 Protein".
Below are MeSH descriptors whose meaning is more specific than "KRIT1 Protein".
This graph shows the total number of publications written about "KRIT1 Protein" by people in this website by year, and whether "KRIT1 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "KRIT1 Protein" by people in Profiles.
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Schwefel K, Spiegler S, Kirchmaier BC, Dellweg PKE, Much CD, Pan?-Farr? J, Strom TM, Riedel K, Felbor U, Rath M. Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3. FASEB J. 2020 07; 34(7):9018-9033.
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Spiegler S, Rath M, Much CD, Sendtner BS, Felbor U. Precise CCM1 gene correction and inactivation in patient-derived endothelial cells: Modeling Knudson's two-hit hypothesis in vitro. Mol Genet Genomic Med. 2019 07; 7(7):e00755.
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Labowsky MT, Walter SD, McDonald MT, Mruthyunjaya P. Neuro-oculo-cutaneous cavernous hemangiomas: a CCM1 mutation-associated phakomatosis. J AAPOS. 2017 Oct; 21(5):426-429.e1.
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Gault J, Awad IA, Recksiek P, Shenkar R, Breeze R, Handler M, Kleinschmidt-DeMasters BK. Cerebral cavernous malformations: somatic mutations in vascular endothelial cells. Neurosurgery. 2009 Jul; 65(1):138-44; discussion 144-5.
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Gault J, Sain S, Hu LJ, Awad IA. Spectrum of genotype and clinical manifestations in cerebral cavernous malformations. Neurosurgery. 2006 Dec; 59(6):1278-84; discussion 1284-5.
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Gault J, Shenkar R, Recksiek P, Awad IA. Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion. Stroke. 2005 Apr; 36(4):872-4.
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