 Wnt-5a Protein
"Wnt-5a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Wnt protein and ligand for FRIZZLED RECEPTORS that may function as an inhibitor or activator of the WNT SIGNALING PATHWAY. For example, it activates signaling in the presence of Frizzled-4 but is inhibitory when coupled with ROR2 TYROSINE KINASE. It is required for axis formation during EMBRYOGENESIS and inhibits the proliferation, migration, and invasiveness of cancer cells.
| Descriptor ID |
D000071818
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| MeSH Number(s) |
D12.776.467.984.050 D12.776.624.664.700.962 D23.529.984.050
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| Concept/Terms |
Wnt-5a Protein- Wnt-5a Protein
- Wnt 5a Protein
- Wingless-Type MMTV Integration Site Family, Member 5A
- Wingless Type MMTV Integration Site Family, Member 5A
- Wnt5a Protein
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Below are MeSH descriptors whose meaning is more general than "Wnt-5a Protein".
Below are MeSH descriptors whose meaning is more specific than "Wnt-5a Protein".
This graph shows the total number of publications written about "Wnt-5a Protein" by people in this website by year, and whether "Wnt-5a Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 2 | 2 | 4 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Wnt-5a Protein" by people in Profiles.
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Poppova L, Pavlova S, Gonzalez B, Kotaskova J, Plevova K, Dumbovic G, Janovska P, Bystry V, Panovska A, Bezdekova L, Maslejova S, Brychtova Y, Doubek M, Krzyzankova M, Borsky M, Mayer J, Bryja V, Alonso S, Pospisilova S. Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene. Epigenetics. 2022 12; 17(12):1628-1635.
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Yao Q, Epstein CB, Banskota S, Issner R, Kim Y, Bernstein BE, Pinello L, Asgari MM. Epigenetic Alterations in Keratinocyte Carcinoma. J Invest Dermatol. 2021 05; 141(5):1207-1218.
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Martin-Medina A, Lehmann M, Burgy O, Hermann S, Baarsma HA, Wagner DE, De Santis MM, Ciolek F, Hofer TP, Frankenberger M, Aichler M, Lindner M, Gesierich W, Guenther A, Walch A, Coughlan C, Wolters P, Lee JS, Behr J, K?nigshoff M. Increased Extracellular Vesicles Mediate WNT5A Signaling in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 12 15; 198(12):1527-1538.
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Merks AM, Swinarski M, Meyer AM, M?ller NV, ?zcan I, Donat S, Burger A, Gilbert S, Mosimann C, Abdelilah-Seyfried S, Pan?kov? D. Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nat Commun. 2018 06 04; 9(1):2161.
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Mumford PW, Romero MA, Mao X, Mobley CB, Kephart WC, Haun CT, Roberson PA, Young KC, Martin JS, Yarrow JF, Beck DT, Roberts MD. Cross talk between androgen and Wnt signaling potentially contributes to age-related skeletal muscle atrophy in rats. J Appl Physiol (1985). 2018 08 01; 125(2):486-494.
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Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 01 01; 27(1):107-119.
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Connacher MK, Tay JW, Ahn NG. Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration. Mol Biol Cell. 2017 Jul 07; 28(14):1924-1936.
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Behera R, Kaur A, Webster MR, Kim S, Ndoye A, Kugel CH, Alicea GM, Wang J, Ghosh K, Cheng P, Lisanti S, Marchbank K, Dang V, Levesque M, Dummer R, Xu X, Herlyn M, Aplin AE, Roesch A, Caino C, Altieri DC, Weeraratna AT. Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho. Clin Cancer Res. 2017 Jun 15; 23(12):3181-3190.
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Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, G?nther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim A?, K?nigshoff M. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017 01; 214(1):143-163.
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Dietz K, de Los Reyes Jim?nez M, Gollwitzer ES, Chaker AM, Zissler UM, R?dmark OP, Baarsma HA, K?nigshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J. Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways. J Allergy Clin Immunol. 2017 Apr; 139(4):1343-1354.e6.
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