 Karyopherins
"Karyopherins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
| Descriptor ID |
D028884
|
| MeSH Number(s) |
D12.776.157.530.750.500 D12.776.543.585.750.500 D12.776.660.502
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Karyopherins".
Below are MeSH descriptors whose meaning is more specific than "Karyopherins".
This graph shows the total number of publications written about "Karyopherins" by people in this website by year, and whether "Karyopherins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2009 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Karyopherins" by people in Profiles.
-
Wang J, Lee JE, Riemondy K, Yu Y, Marquez SM, Lai EC, Yi R. XPO5 promotes primary miRNA processing independently of RanGTP. Nat Commun. 2020 04 15; 11(1):1845.
-
DeSisto JA, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, Bales NJ, Kashyap T, Moroze E, Venkataraman S, Kung AL, Carter BD, Landesman Y, Vibhakar R, Green AL. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-?B Pathway in Preclinical Models of Pediatric High-Grade Glioma. Mol Cancer Ther. 2020 02; 19(2):540-551.
-
Marcus JM, Burke RT, Doak AE, Park S, Orth JD. Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death. Cell Cycle. 2018; 17(11):1329-1344.
-
Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, Rodell CB, Burdick JA, King OD, Gitler AD, Lagier-Tourenne C, Pandey UB, Chook YM, Taylor JP, Shorter J. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018 04 19; 173(3):677-692.e20.
-
Vogl DT, Dingli D, Cornell RF, Huff CA, Jagannath S, Bhutani D, Zonder J, Baz R, Nooka A, Richter J, Cole C, Vij R, Jakubowiak A, Abonour R, Schiller G, Parker TL, Costa LJ, Kaminetzky D, Hoffman JE, Yee AJ, Chari A, Siegel D, Fonseca R, Van Wier S, Ahmann G, Lopez I, Kauffman M, Shacham S, Saint-Martin JR, Picklesimer CD, Choe-Juliak C, Stewart AK. Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma. J Clin Oncol. 2018 03 20; 36(9):859-866.
-
Burke RT, Marcus JM, Orth JD. Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. Oncotarget. 2017 Jun 13; 8(24):39460-39475.
-
Jia H, Zhang X, Wang W, Bai Y, Ling Y, Cao C, Ma RZ, Zhong H, Wang X, Xu Q. A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphase. BMC Cell Biol. 2015 Feb 27; 16:6.
-
Green AL, Ramkissoon SH, McCauley D, Jones K, Perry JA, Hsu JH, Ramkissoon LA, Maire CL, Hubbell-Engler B, Knoff DS, Shacham S, Ligon KL, Kung AL. Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. Neuro Oncol. 2015 May; 17(5):697-707.
-
Pierce JB, Chafe SC, Eswara MB, van der Merwe G, Mangroo D. Strategies for investigating nuclear-cytoplasmic tRNA dynamics in yeast and mammalian cells. Methods Cell Biol. 2014; 122:415-36.
-
Pierce JB, van der Merwe G, Mangroo D. Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p. Eukaryot Cell. 2014 Feb; 13(2):209-30.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|