Proto-Oncogene Proteins c-bcr

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"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.

Descriptor ID	D051562
MeSH Number(s)	D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171
Concept/Terms	Proto-Oncogene Proteins c-bcr Proto-Oncogene Proteins c-bcr Proto Oncogene Proteins c bcr c-bcr, Proto-Oncogene Proteins Proto-Oncogene Protein c-bcr Proto Oncogene Protein c bcr c-bcr, Proto-Oncogene Protein Breakpoint Cluster Region Protein c-bcr Proteins c bcr Proteins c-bcr Proto-Oncogene Proteins Proto-Oncogene Proteins, c-bcr c bcr Proto Oncogene Proteins bcr Proto-Oncogene Proteins Proto-Oncogene Proteins, bcr bcr Proto Oncogene Proteins Proto-Oncogene Protein bcr Proto Oncogene Protein bcr

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
GTP-Binding Protein Regulators [D12.644.360.325]
Guanine Nucleotide Exchange Factors [D12.644.360.325.300]
Rho Guanine Nucleotide Exchange Factors [D12.644.360.325.300.099]
Proto-Oncogene Proteins c-bcr [D12.644.360.325.300.099.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
GTP-Binding Protein Regulators [D12.776.476.325]
Guanine Nucleotide Exchange Factors [D12.776.476.325.300]
Rho Guanine Nucleotide Exchange Factors [D12.776.476.325.300.099]
Proto-Oncogene Proteins c-bcr [D12.776.476.325.300.099.500]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-bcr".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".

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