 Pre-B-Cell Leukemia Transcription Factor 1
"Pre-B-Cell Leukemia Transcription Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
| Descriptor ID |
D000075062
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| MeSH Number(s) |
D12.776.260.400.836 D12.776.624.664.700.163 D12.776.930.712
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| Concept/Terms |
Pre-B-Cell Leukemia Transcription Factor 1- Pre-B-Cell Leukemia Transcription Factor 1
- Pre B Cell Leukemia Transcription Factor 1
- PBX1 Homeobox Protein
- Homeobox Protein, PBX1
- Pre-B-Cell Leukemia Homeobox 1 Protein
- Pre B Cell Leukemia Homeobox 1 Protein
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Below are MeSH descriptors whose meaning is more general than "Pre-B-Cell Leukemia Transcription Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Pre-B-Cell Leukemia Transcription Factor 1".
This graph shows the total number of publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in this website by year, and whether "Pre-B-Cell Leukemia Transcription Factor 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in Profiles.
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Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L. Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion. Development. 2018 03 01; 145(5).
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Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL. Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity. J Clin Invest. 2014 Jan; 124(1):222-36.
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Ferretti E, Li B, Zewdu R, Wells V, Hebert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L. A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell. 2011 Oct 18; 21(4):627-41.
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Bjerke GA, Hyman-Walsh C, Wotton D. Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. Mol Cell Biol. 2011 Sep; 31(18):3723-33.
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Hyman-Walsh C, Bjerke GA, Wotton D. An autoinhibitory effect of the homothorax domain of Meis2. FEBS J. 2010 Jun; 277(12):2584-97.
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Sagerstr?m CG. PbX marks the spot. Dev Cell. 2004 Jun; 6(6):737-8.
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Choe SK, Vlachakis N, Sagerstr?m CG. Meis family proteins are required for hindbrain development in the zebrafish. Development. 2002 Feb; 129(3):585-95.
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Vlachakis N, Ellstrom DR, Sagerstr?m CG. A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b. Dev Dyn. 2000 Jan; 217(1):109-19.
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