 Retinoblastoma-Like Protein p107
"Retinoblastoma-Like Protein p107" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
| Descriptor ID |
D050720
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| MeSH Number(s) |
D12.776.624.776.717 D12.776.660.770 D12.776.744.747
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| Concept/Terms |
Retinoblastoma-Like Protein p107- Retinoblastoma-Like Protein p107
- p107, Retinoblastoma-Like Protein
- Retinoblastoma-Like Protein 1
- Retinoblastoma Like Protein 1
- RBL1 Protein
- Retinoblastoma Like Protein p107
- p107 Tumor Suppressor Protein
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Below are MeSH descriptors whose meaning is more general than "Retinoblastoma-Like Protein p107".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma-Like Protein p107".
This graph shows the total number of publications written about "Retinoblastoma-Like Protein p107" by people in this website by year, and whether "Retinoblastoma-Like Protein p107" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Retinoblastoma-Like Protein p107" by people in Profiles.
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Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 2010 May; 138(5):1920-30.
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Tyagi A, Agarwal C, Agarwal R. The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells. Cell Cycle. 2002 Mar-Apr; 1(2):137-42.
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Knudsen ES, Wang JY. Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130. Oncogene. 1998 Apr 02; 16(13):1655-63.
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Chen Y, Knudsen ES, Wang JY. The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells. Oncogene. 1996 Oct 17; 13(8):1765-71.
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