 Retinoblastoma-Like Protein p107
"Retinoblastoma-Like Protein p107" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. It contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
| Descriptor ID |
D050720
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| MeSH Number(s) |
D12.776.624.776.717 D12.776.660.770 D12.776.744.747
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| Concept/Terms |
Retinoblastoma-Like Protein p107- Retinoblastoma-Like Protein p107
- p107, Retinoblastoma-Like Protein
- Retinoblastoma-Like Protein 1
- Retinoblastoma Like Protein 1
- RBL1 Protein
- Retinoblastoma Like Protein p107
- p107 Tumor Suppressor Protein
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Below are MeSH descriptors whose meaning is more general than "Retinoblastoma-Like Protein p107".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma-Like Protein p107".
This graph shows the total number of publications written about "Retinoblastoma-Like Protein p107" by people in this website by year, and whether "Retinoblastoma-Like Protein p107" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Retinoblastoma-Like Protein p107" by people in Profiles.
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Perampalam P, Hassan HM, Lilly GE, Passos DT, Torchia J, Kiser PK, Bozovic A, Kulasingam V, Dick FA. Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice. J Clin Invest. 2021 02 15; 131(4).
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Rivadeneira DB, Mayhew CN, Thangavel C, Sotillo E, Reed CA, Graña X, Knudsen ES. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 2010 May; 138(5):1920-30.
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Tyagi A, Agarwal C, Agarwal R. The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells. Cell Cycle. 2002 Mar-Apr; 1(2):137-42.
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Knudsen ES, Wang JY. Hyperphosphorylated p107 and p130 bind to T-antigen: identification of a critical regulatory sequence present in RB but not in p107/p130. Oncogene. 1998 Apr 02; 16(13):1655-63.
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Chen Y, Knudsen ES, Wang JY. The RB/p107/p130 phosphorylation pathway is not inhibited in rapamycin-induced G1-prolongation of NIH3T3 cells. Oncogene. 1996 Oct 17; 13(8):1765-71.
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