 Ku Autoantigen
"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.
| Descriptor ID |
D000072200
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| MeSH Number(s) |
D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
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| Concept/Terms |
Ku Autoantigen- Ku Autoantigen
- Autoantigen, Ku
- Ku Heterodimer
- Heterodimer, Ku
- Ku Protein
- Ku Antigen
- Antigen, Ku
- G22P1 Antigen
- Antigen, G22P1
Ku80 Antigen- Ku80 Antigen
- Antigen, Ku80
- Ku Autoantigen, 80 kDa
- XRCC5 Protein
- X-ray Repair Cross-Complementing Protein 5
- X ray Repair Cross Complementing Protein 5
Ku70 Antigen- Ku70 Antigen
- Antigen, Ku70
- Ku Autoantigen, 70 kDa
- XRCC6 Protein
- X-ray Repair Cross-Complementing Protein 6
- X ray Repair Cross Complementing Protein 6
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Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".
Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".
This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2004 | 0 | 2 | 2 | | 2013 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.
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Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J. Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN. Nature. 2017 09 20; 549(7673):548-552.
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Vaitaitis GM, Wagner DH. CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression. Cell Mol Immunol. 2013 Nov; 10(6):483-9.
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Hersh CP, Pillai SG, Zhu G, Lomas DA, Bakke P, Gulsvik A, DeMeo DL, Klanderman BJ, Lazarus R, Litonjua AA, Sparrow D, Reilly JJ, Agusti A, Calverley PM, Donner CF, Levy RD, Make BJ, Par? PD, Rennard SI, Vestbo J, Wouters EF, Scholand MB, Coon H, Hoidal J, Silverman EK. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med. 2010 Sep 01; 182(5):605-13.
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Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27.
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Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9.
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Teoh NC, Dan YY, Swisshelm K, Lehman S, Wright JH, Haque J, Gu Y, Fausto N. Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology. 2008 Jun; 47(6):2078-88.
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MacLaren EJ, Bennett B, Johnson TE, Sikela JM. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. Mamm Genome. 2006 Feb; 17(2):147-56.
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Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L. The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression. Mol Cell Biol. 2004 Oct; 24(19):8705-15.
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Wuttke DS. Targeting the end; the structure of the Ku80 C-terminal domain. Structure. 2004 Mar; 12(3):355-6.
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Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 2000 Oct; 11(10):3265-75.
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