 Promyelocytic Leukemia Protein
"Promyelocytic Leukemia Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells.
| Descriptor ID |
D000071156
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| MeSH Number(s) |
D12.776.624.776.654 D12.776.660.745 D12.776.930.713 D12.776.934.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Protein".
Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Protein".
This graph shows the total number of publications written about "Promyelocytic Leukemia Protein" by people in this website by year, and whether "Promyelocytic Leukemia Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Promyelocytic Leukemia Protein" by people in Profiles.
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Nichol JN, Galbraith MD, Kleinman CL, Espinosa JM, Miller WH. NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia. Cell Rep. 2016 Mar 29; 14(12):2938-49.
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Erickson KD, Bouchet-Marquis C, Heiser K, Szomolanyi-Tsuda E, Mishra R, Lamothe B, Hoenger A, Garcea RL. Virion assembly factories in the nucleus of polyomavirus-infected cells. PLoS Pathog. 2012; 8(4):e1002630.
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Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londo?o-Vallejo A. Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15726-31.
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Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Mol Cell Biol. 2005 Oct; 25(20):8925-37.
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