 Retinoblastoma Protein
"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.
| Descriptor ID |
D016160
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| MeSH Number(s) |
D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
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| Concept/Terms |
p105-Rb Protein- p105-Rb Protein
- p105 Rb Protein
- Retinoblastoma Nuclear Phosphoprotein p105-Rb
- Retinoblastoma Nuclear Phosphoprotein p105 Rb
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Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".
This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 1 | 4 | | 1997 | 4 | 2 | 6 | | 1998 | 3 | 1 | 4 | | 1999 | 1 | 0 | 1 | | 2000 | 4 | 2 | 6 | | 2001 | 2 | 0 | 2 | | 2002 | 3 | 0 | 3 | | 2003 | 1 | 0 | 1 | | 2004 | 5 | 2 | 7 | | 2005 | 0 | 5 | 5 | | 2006 | 2 | 1 | 3 | | 2007 | 4 | 0 | 4 | | 2008 | 2 | 4 | 6 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 1 | 2 | | 2011 | 4 | 1 | 5 | | 2012 | 2 | 3 | 5 | | 2013 | 1 | 4 | 5 | | 2014 | 4 | 1 | 5 | | 2015 | 1 | 2 | 3 | | 2016 | 0 | 3 | 3 | | 2017 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 | | 2025 | 2 | 0 | 2 | | 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.
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Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Kitagawa M, San TY, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Murine Embryonic Stem Cells Possess Distinct E2F Activity That Activates Tumor Suppressor Promoter Elements. Genes Cells. 2026 May; 31(3):e70121.
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Zhou Y, Nakajima R, Shirasawa M, Fikriyanti M, Watanabe A, Yang C, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. Distinct Regulation of the ARF and TAp73 Tumor Suppressor Genes by the Transcription Factor E2F1 Enables Discrimination of Cancer Cells from Normal Growing Cells. Cells. 2026 Jan 05; 15(1).
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Khong A, Ripin N, de Vasconcelos LM, Passanisi V, Spencer S, Parker R. Stress granules promote quiescence by enhancing p21 levels and reducing phospho-Rb. RNA. 2025 09 16; 31(10):1472-1487.
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Nakajima R, Zhou Y, Shirasawa M, Fikriyanti M, Iwanaga R, Bradford AP, Kurayoshi K, Araki K, Ohtani K. The Transcriptional Coactivator DEAD/H Box 5 (DDX5) Gene Is a Target of the Transcription Factor E2F1 Deregulated from the Tumor Suppressor pRB. Genes (Basel). 2025 Aug 01; 16(8).
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Kumarasamy V, Nambiar R, Wang J, Rosenheck H, Witkiewicz AK, Knudsen ES. RB loss determines selective resistance and novel vulnerabilities in ER-positive breast cancer models. Oncogene. 2022 07; 41(27):3524-3538.
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Sturmlechner I, Zhang C, Sine CC, van Deursen EJ, Jeganathan KB, Hamada N, Grasic J, Friedman D, Stutchman JT, Can I, Hamada M, Lim DY, Lee JH, Ordog T, Laberge RM, Shapiro V, Baker DJ, Li H, van Deursen JM. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021 Oct 29; 374(6567):eabb3420.
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Sousa LO, Sobral LM, de Almeida LO, Garcia CB, Greene LJ, Leopoldino AM. SET protein modulates H4 histone methylation status and regulates miR-137 level in oral squamous cell carcinoma. Epigenomics. 2020 03; 12(6):475-485.
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Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 12 13; 366(6471).
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Moser J, Miller I, Carter D, Spencer SL. Control of the Restriction Point by Rb and p21. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8219-E8227.
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Witkiewicz AK, Chung S, Brough R, Vail P, Franco J, Lord CJ, Knudsen ES. Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer. Cell Rep. 2018 01 30; 22(5):1185-1199.
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