Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Mercedes Rincon

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Research 
    Collapse research activities and funding
    R01CA301643     (DEGREGORI, JAMES V)Mar 1, 2025 - Feb 28, 2030
    NIH
    Role of respiratory viral infections and inflammation in promoting metastatic outgrowth in the lung
    Role: Co-Principal Investigator
    R21CA287678     (RINCON, MERCEDES)Jul 1, 2024 - Jun 30, 2026
    NIH
    IL-6 and IL-6R genetic polymorphisms in immune-related adverse events caused by cancer immunotherapy
    Role: Principal Investigator
    R21AI167201     (RINCON, MERCEDES)Jul 1, 2022 - Jun 30, 2024
    NIH
    GSK3b and dsRNA in CD8 cells
    Role: Principal Investigator
    R01CA260909     (RINCON, MERCEDES)Mar 1, 2022 - Feb 28, 2027
    NIH
    Enhancing mitochondrial metabolism to improve anti-tumor CD8 immune response
    Role: Principal Investigator
    R44DK129102     (ARBEENY, CYNTHIA)Jun 1, 2021 - Jul 31, 2024
    NIH
    A novel approach to treat non-alcoholic steatohepatitis (NASH)
    Role: Co-Principal Investigator
    R56AI148434     (RINCON, MERCEDES)Dec 1, 2020 - Nov 30, 2021
    NIH
    Targeting mitochondrial regulator MCJ to enhance CD8 cell immune response
    Role: Principal Investigator
    R21AI149187     (RINCON, MERCEDES)Jan 31, 2020 - Dec 31, 2021
    NIH
    Fine-tuning of mitochondrial Complex I activity in CD8 cells
    Role: Principal Investigator
    R41DK117760     (RINCON, MERCEDES)Jul 1, 2018 - Jan 27, 2021
    NIH
    A Novel Treatment for Acetominophen-Induced Liver Injury
    Role: Principal Investigator
    R21CA223389     (RINCON, MERCEDES)Jun 1, 2018 - May 31, 2021
    NIH
    A novel target to overcome chemoresistance in breast cancer
    Role: Principal Investigator
    R41DK112429     (RINCON, MERCEDES)Jul 5, 2017 - Jun 30, 2019
    NIH
    A novel approach to treat non-alcoholic steatohepatitis (NASH)
    Role: Principal Investigator
    R56AI116255     (RINCON, MERCEDES)May 1, 2016 - Apr 30, 2018
    NIH
    IL-6 as a regulator of mitochondria function in T cells
    Role: Principal Investigator
    R25GM116701     (IRVIN, CHARLES G.)Apr 1, 2016 - Feb 28, 2021
    NIH
    Fostering entrepreneurship in biomedical research
    Role: Co-Principal Investigator
    R21AI110016     (RINCON, MERCEDES)Feb 10, 2014 - Jan 31, 2017
    NIH
    Regulation of mitochondrial function in T cells
    Role: Principal Investigator
    R56AI094027     (RINCON, MERCEDES)Apr 15, 2012 - Mar 31, 2014
    NIH
    IL-6: an innate immune regulator for the plasticity of Tfh cells
    Role: Principal Investigator
    R21CA127099     (RINCON, MERCEDES)Apr 1, 2007 - Feb 28, 2011
    NIH
    MCJ function in mouse mammary tumor properties
    Role: Principal Investigator
    R01AI051454     (RINCON, MERCEDES)Jun 1, 2002 - Jul 31, 2021
    NIH
    GSK3B in TCR repertoire and immune diseases
    Role: Principal Investigator
    R56AI051454     (RINCON, MERCEDES R.)Jun 1, 2002 - Jan 31, 2009
    NIH
    p38 MAP kinase in early thymocyte development
    Role: Principal Investigator
    R21AI051454     (RINCON, MERCEDES R.)Jun 1, 2002 - May 31, 2003
    NIH
    p53 and p38 MAP Kinase in thymocyte development
    Role: Principal Investigator
    R01HL069136     (RINCON, MERCEDES R.)Sep 30, 2001 - Jul 31, 2007
    NIH
    Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Role: Principal Investigator
    R29AI042138     (RINCON, MERCEDES R.)Jun 1, 1998 - May 31, 2003
    NIH
    SIGNALING PATHWAYS--THYMIC T CELL DEVELOPMENT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Grayck MR, Smith BJ, Sosa A, Golden E, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Dobrinskikh E, Rincon M, McCulley DJ, Orlicky DJ, Wright CJ. A Single Early Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung. Am J Respir Cell Mol Biol. 2025 Jan 21. PMID: 39836061.
      View in: PubMed
    2. Valen?a-Pereira F, Sheridan RM, Riemondy KA, Thornton T, Fang Q, Barret B, Paludo G, Thompson C, Collins P, Santiago M, Oltz E, Rincon M. Inactivation of GSK3? by Ser389 phosphorylation prevents thymocyte necroptosis and impacts Tcr repertoire diversity. Cell Death Differ. 2025 May; 32(5):880-898. PMID: 39779909.
      View in: PubMed
    3. Wu MH, Valenca-Pereira F, Cendali F, Giddings EL, Pham-Danis C, Yarnell MC, Novak AJ, Brunetti TM, Thompson SB, Henao-Mejia J, Flavell RA, D'Alessandro A, Kohler ME, Rincon M. Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies. Nat Commun. 2024 May 24; 15(1):4444. PMID: 38789421.
      View in: PubMed
    4. Chia SB, Johnson BJ, Hu J, Vermeulen R, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, Pereira FV, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Papanicolaou M, Beheshti A, Baylin SB, Costello J, Bartley JM, Morrison TE, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs. Res Sq. 2024 Apr 05. PMID: 38645169.
      View in: PubMed
    5. Calvo B, Fernandez M, Rincon M, Tranque P. GSK3? Inhibition by Phosphorylation at Ser389 Controls Neuroinflammation. Int J Mol Sci. 2022 Dec 25; 24(1). PMID: 36613781.
      View in: PubMed
    6. Stancil IT, Michalski JE, Hennessy CE, Hatakka KL, Yang IV, Kurche JS, Rincon M, Schwartz DA. Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling. Sci Transl Med. 2022 07 20; 14(654):eabo5254. PMID: 35857823.
      View in: PubMed
    7. Valen?a-Pereira F, Fang Q, Mari? IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M. IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway. Proc Natl Acad Sci U S A. 2021 09 14; 118(37). PMID: 34507993.
      View in: PubMed
    8. Giddings EL, Champagne DP, Wu MH, Laffin JM, Thornton TM, Valenca-Pereira F, Culp-Hill R, Fortner KA, Romero N, East J, Cao P, Arias-Pulido H, Sidhu KS, Silverstrim B, Kam Y, Kelley S, Pereira M, Bates SE, Bunn JY, Fiering SN, Matthews DE, Robey RW, Stich D, D'Alessandro A, Rincon M. Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance. Nat Commun. 2021 05 14; 12(1):2804. PMID: 33990571.
      View in: PubMed
    9. Calvo B, Thornton TM, Rincon M, Tranque P, Fernandez M. Regulation of GSK3? by Ser389 Phosphorylation During Neural Development. Mol Neurobiol. 2021 Feb; 58(2):809-820. PMID: 33029741.
      View in: PubMed
    10. Menson KE, Mank MM, Reed LF, Walton CJ, Van Der Vliet KE, Ather JL, Chapman DG, Smith BJ, Rincon M, Poynter ME. Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma. Am J Physiol Lung Cell Mol Physiol. 2020 10 01; 319(4):L693-L709. PMID: 32783616.
      View in: PubMed
    11. Karki A, Giddings E, Carreras A, Champagne D, Fortner K, Rincon M, Wu J. Sonoporation as an Approach for siRNA delivery into T cells. Ultrasound Med Biol. 2019 12; 45(12):3222-3231. PMID: 31540758.
      View in: PubMed
    12. Rincon M, Pereira FV. A New Perspective: Mitochondrial Stat3 as a Regulator for Lymphocyte Function. Int J Mol Sci. 2018 Jun 04; 19(6). PMID: 29866996.
      View in: PubMed
    13. Hare BD, Thornton TM, Rincon M, Golijanin B, King SB, Jaworski DM, Falls WA. Two Weeks of Variable Stress Increases Gamma-H2AX Levels in the Mouse Bed Nucleus of the Stria Terminalis. Neuroscience. 2018 03 01; 373:137-144. PMID: 29352998.
      View in: PubMed
    14. Thornton TM, Hare B, Coli? S, Pendlebury WW, Nebreda AR, Falls W, Jaworski DM, Rincon M. Failure to Inactivate Nuclear GSK3? by Ser389-Phosphorylation Leads to Focal Neuronal Death and Prolonged Fear Response. Neuropsychopharmacology. 2018 Jan; 43(2):393-405. PMID: 28832021.
      View in: PubMed
    15. Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-Cas?s N, Silberger DJ, Weaver CT, Haynes L, Rincon M. IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells. J Exp Med. 2016 10 17; 213(11):2281-2291. PMID: 27670591.
      View in: PubMed
    16. Champagne DP, Hatle KM, Fortner KA, D'Alessandro A, Thornton TM, Yang R, Torralba D, Tom?s-Cort?zar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M. Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus. Immunity. 2016 06 21; 44(6):1299-311. PMID: 27234056.
      View in: PubMed
    17. Fern?ndez-Cabezudo MJ, Faour I, Jones K, Champagne DP, Jaloudi MA, Mohamed YA, Bashir G, Almarzooqi S, Albawardi A, Hashim MJ, Roberts TS, El-Salhat H, El-Taji H, Kassis A, O'Sullivan DE, Christensen BC, DeGregori J, Al-Ramadi BK, Rincon M. Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer. JCI Insight. 2016 May 19; 1(7). PMID: 27275014.
      View in: PubMed
    18. Yang R, Rincon M. Mitochondrial Stat3, the Need for Design Thinking. Int J Biol Sci. 2016; 12(5):532-44. PMID: 27019635.
      View in: PubMed
    19. Krementsov DN, Thornton TM, Teuscher C, Rincon M. The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models. Mol Cell Biol. 2013 Oct; 33(19):3728-34. PMID: 23897428.
      View in: PubMed
    20. Hatle KM, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, Fortner K, Burg E, Suratt BT, Hammer J, Radermacher M, Taatjes DJ, Thornton T, Anguita J, Rincon M. MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol. 2013 Jun; 33(11):2302-14. PMID: 23530063.
      View in: PubMed
    21. Noubade R, Krementsov DN, Del Rio R, Thornton T, Nagaleekar V, Saligrama N, Spitzack A, Spach K, Sabio G, Davis RJ, Rincon M, Teuscher C. Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis. Blood. 2011 Sep 22; 118(12):3290-300. PMID: 21791428.
      View in: PubMed
    22. Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, Whittaker LA, Rincon M. Fungal allergen ?-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1133-41. PMID: 21642586.
      View in: PubMed
    23. Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE. Translational control of NKT cell cytokine production by p38 MAPK. J Immunol. 2011 Apr 01; 186(7):4140-6. PMID: 21368234.
      View in: PubMed
    24. H?bner A, Cavanagh-Kyros J, Rincon M, Flavell RA, Davis RJ. Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. Mol Cell Biol. 2010 Jan; 30(1):98-105. PMID: 19841067.
      View in: PubMed
    25. Wood CD, Thornton TM, Sabio G, Davis RA, Rincon M. Nuclear localization of p38 MAPK in response to DNA damage. Int J Biol Sci. 2009 Jun 16; 5(5):428-37. PMID: 19564926.
      View in: PubMed
    26. Allard JB, Rinaldi L, Wargo MJ, Allen G, Akira S, Uematsu S, Poynter ME, Hogan DA, Rincon M, Whittaker LA. Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Eur J Immunol. 2009 Mar; 39(3):776-88. PMID: 19224641.
      View in: PubMed
    27. Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med. 2009 Jan 16; 206(1):69-78. PMID: 19139170.
      View in: PubMed
    28. Thornton TM, Rincon M. Non-classical p38 map kinase functions: cell cycle checkpoints and survival. Int J Biol Sci. 2009; 5(1):44-51. PMID: 19159010.
      View in: PubMed
    29. Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science. 2008 May 02; 320(5876):667-70. PMID: 18451303.
      View in: PubMed
    30. Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, Rincon M, Teuscher C. Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Invest. 2007 Nov; 117(11):3507-18. PMID: 17965772.
      View in: PubMed
    31. Allard JB, Poynter ME, Marr KA, Cohn L, Rincon M, Whittaker LA. Aspergillus fumigatus generates an enhanced Th2-biased immune response in mice with defective cystic fibrosis transmembrane conductance regulator. J Immunol. 2006 Oct 15; 177(8):5186-94. PMID: 17015704.
      View in: PubMed
    32. Lee PJ, Zhang X, Shan P, Ma B, Lee CG, Homer RJ, Zhu Z, Rincon M, Mossman BT, Elias JA. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan; 116(1):163-73. PMID: 16374521.
      View in: PubMed
    33. Jimi E, Phillips RJ, Rincon M, Voll R, Karasuyama H, Flavell R, Ghosh S. Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 2005 Jun; 17(6):815-25. PMID: 15908447.
      View in: PubMed
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