 Proto-Oncogene Proteins c-cbl
"Proto-Oncogene Proteins c-cbl" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a UBIQUITIN-PROTEIN LIGASE and the cellular homologue of ONCOGENE PROTEIN V-CBL.
| Descriptor ID |
D050721
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| MeSH Number(s) |
D08.811.464.938.750.374 D12.776.624.664.700.172
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| Concept/Terms |
Proto-Oncogene Proteins c-cbl- Proto-Oncogene Proteins c-cbl
- Proto Oncogene Proteins c cbl
- c-cbl, Proto-Oncogene Proteins
- RING Finger Protein 55
- c-cbl Protein
- cbl Proto-Oncogene Protein
- Proto-Oncogene Protein, cbl
- cbl Proto Oncogene Protein
- CBL E3 Ubiquitin Protein Ligase
- c-cbl Proto-Oncogene Protein
- Proto-Oncogene Protein, c-cbl
- c cbl Proto Oncogene Protein
- RNF55 Protein
- Proto-Oncogene Protein c-cbl
- Proto Oncogene Protein c cbl
- c-cbl, Proto-Oncogene Protein
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-cbl".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-cbl".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-cbl" by people in this website by year, and whether "Proto-Oncogene Proteins c-cbl" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-cbl" by people in Profiles.
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Hecht A, Meyer JA, Behnert A, Wong E, Chehab F, Olshen A, Hechmer A, Aftandilian C, Bhat R, Choi SW, Chonat S, Farrar JE, Fluchel M, Frangoul H, Han JH, Kolb EA, Kuo DJ, MacMillan ML, Maese L, Maloney KW, Narendran A, Oshrine B, Schultz KR, Sulis ML, Van Mater D, Tasian SK, Hofmann WK, Loh ML, Stieglitz E. Molecular and phenotypic diversity of CBL-mutated juvenile myelomonocytic leukemia. Haematologica. 2022 01 01; 107(1):178-186.
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Norris GA, Tsai AC, Schneider KW, Wu YH, Caulfield T, Green AL. A novel, germline, deactivating CBL variant p.L493F alters domain orientation and is associated with multiple childhood cancers. Cancer Genet. 2021 06; 254-255:18-24.
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Kumar J, Kumar R, Kumar Singh A, Tsakem EL, Kathania M, Riese MJ, Theiss AL, Davila ML, Venuprasad K. Deletion of Cbl-b inhibits CD8+ T-cell exhaustion and promotes CAR T-cell function. J Immunother Cancer. 2021 01; 9(1).
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Shah NN, Qin H, Yates B, Su L, Shalabi H, Raffeld M, Ahlman MA, Stetler-Stevenson M, Yuan C, Guo S, Liu S, Hughes SH, Fry TJ, Wu X. Clonal expansion of CAR T cells harboring lentivector integration in the CBL gene following anti-CD22 CAR T-cell therapy. Blood Adv. 2019 08 13; 3(15):2317-2322.
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Noble M, Mayer-Pr?schel M, Li Z, Dong T, Cui W, Pr?schel C, Ambeskovic I, Dietrich J, Han R, Yang YM, Folts C, Stripay J, Chen HY, Stevens BM. Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment. Free Radic Biol Med. 2015 Feb; 79:300-23.
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Stevens BM, Folts CJ, Cui W, Bardin AL, Walter K, Carson-Walter E, Vescovi A, Noble M. Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo. Stem Cells. 2014 May; 32(5):1124-35.
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Chen HY, Yang YM, Stevens BM, Noble M. Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells. EMBO Mol Med. 2013 May; 5(5):723-36.
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Doherty M, Osborne DG, Browning DL, Parker DC, Wetzel SA. Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b. J Immunol. 2010 Apr 01; 184(7):3598-608.
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Purev E, Neff L, Horne WC, Baron R. c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes. Mol Biol Cell. 2009 Sep; 20(18):4021-30.
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Yang B, Gay DL, MacLeod MK, Cao X, Hala T, Sweezer EM, Kappler J, Marrack P, Oliver PM. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008 Dec; 9(12):1356-63.
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