 Proto-Oncogene Proteins pp60(c-src)
"Proto-Oncogene Proteins pp60(c-src)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of carboxy-terminal residues in pp60(c-src) leads to PP60(V-SRC) which has the ability to transform cells. This kinase pp60 c-src should not be confused with csk, also known as c-src kinase.
| Descriptor ID |
D016392
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| MeSH Number(s) |
D08.811.913.696.620.682.725.800.630 D12.776.624.664.700.202
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| Concept/Terms |
Proto-Oncogene Proteins pp60(c-src)- Proto-Oncogene Proteins pp60(c-src)
- Phosphoprotein pp60(c-src)
- pp60 c-src
- c-src, pp60
- pp60 c src
- pp60(c-src)
- Proto-Oncogene Protein src
- Protein src, Proto-Oncogene
- Proto Oncogene Protein src
- src Proto-Oncogene Product
- Proto-Oncogene Product, src
- src Proto Oncogene Product
- src Proto-Oncogene Protein pp60
- src Proto Oncogene Protein pp60
- c-src Protein pp60
- Protein pp60, c-src
- c src Protein pp60
- pp60, c-src Protein
- Proto-Oncogene Protein pp60(c-src)
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins pp60(c-src)".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins pp60(c-src)".
This graph shows the total number of publications written about "Proto-Oncogene Proteins pp60(c-src)" by people in this website by year, and whether "Proto-Oncogene Proteins pp60(c-src)" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 2009 | 2 | 0 | 2 | | 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins pp60(c-src)" by people in Profiles.
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Dabo AJ, Ezegbunam W, Wyman AE, Moon J, Railwah C, Lora A, Majka SM, Geraghty P, Foronjy RF. Targeting c-Src Reverses Accelerated GPX-1 mRNA Decay in Chronic Obstructive Pulmonary Disease Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2020 05; 62(5):598-607.
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Lyu H, Yang XH, Edgerton SM, Thor AD, Wu X, He Z, Liu B. The erbB3- and IGF-1 receptor-initiated signaling pathways exhibit distinct effects on lapatinib sensitivity against trastuzumab-resistant breast cancer cells. Oncotarget. 2016 Jan 19; 7(3):2921-35.
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Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, Karam SD. Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget. 2015 Apr 20; 6(11):8929-46.
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Neuber S, J?ger S, Meyer M, Wischmann V, Koch PJ, Moll R, Schmidt A. c-Src mediated tyrosine phosphorylation of plakophilin 3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress. Cell Tissue Res. 2015 Mar; 359(3):799-816.
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Friend SF, Peterson LK, Kedl RM, Dragone LL. SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunol Res. 2013 Mar; 55(1-3):116-24.
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Peterson LK, Shaw LA, Joetham A, Sakaguchi S, Gelfand EW, Dragone LL. SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice. J Immunol. 2011 Feb 15; 186(4):2273-81.
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Teoh D, Ayeni TA, Rubatt JM, Adams DJ, Grace L, Starr MD, Barry WT, Berchuck A, Murphy SK, Secord AA. Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells. Gynecol Oncol. 2011 Apr; 121(1):187-92.
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Rajeshkumar NV, Tan AC, De Oliveira E, Womack C, Wombwell H, Morgan S, Warren MV, Walker J, Green TP, Jimeno A, Messersmith WA, Hidalgo M. Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer. Clin Cancer Res. 2009 Jun 15; 15(12):4138-46.
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Schweppe RE, Kerege AA, French JD, Sharma V, Grzywa RL, Haugen BR. Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer. J Clin Endocrinol Metab. 2009 Jun; 94(6):2199-203.
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Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res. 2005 Apr 01; 96(6):635-42.
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