 RUNX1 Translocation Partner 1 Protein
"RUNX1 Translocation Partner 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.
| Descriptor ID |
D000075142
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| MeSH Number(s) |
D12.776.624.664.700.936 D12.776.930.780.625.575
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "RUNX1 Translocation Partner 1 Protein".
Below are MeSH descriptors whose meaning is more specific than "RUNX1 Translocation Partner 1 Protein".
This graph shows the total number of publications written about "RUNX1 Translocation Partner 1 Protein" by people in this website by year, and whether "RUNX1 Translocation Partner 1 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
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Below are the most recent publications written about "RUNX1 Translocation Partner 1 Protein" by people in Profiles.
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Nick HJ, Kim HG, Chang CW, Harris KW, Reddy V, Klug CA. Distinct classes of c-Kit-activating mutations differ in their ability to promote RUNX1-ETO-associated acute myeloid leukemia. Blood. 2012 Feb 09; 119(6):1522-31.
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Paskulin GA, Philips G, Morgan R, Sandberg A, Richkind K, Borovik C, McGavran L, Rabinovich N, Dietz-Band J, Erickson P, Drabkin H, Varella-Garcia M. Pre-clinical evaluation of probes to detect t(8;21) AML minimal residual disease by fluorescence in situ hybridization. Genes Chromosomes Cancer. 1998 Feb; 21(2):144-51.
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Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA. ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease. Blood. 1996 Sep 01; 88(5):1813-23.
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