Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Irwin

Concepts (285)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Anemia, Sickle Cell
17
2026
318
6.460
Why?
Hemoglobins
12
2026
386
3.390
Why?
Hemopexin
5
2025
38
2.550
Why?
Hypertension, Pulmonary
13
2026
1957
2.470
Why?
Haptoglobins
6
2026
71
1.660
Why?
beta-Thalassemia
2
2025
40
1.610
Why?
Hemolysis
8
2026
242
1.610
Why?
Hypoxia
12
2026
1199
1.300
Why?
Altitude Sickness
4
2016
141
1.130
Why?
Exercise Tolerance
4
2025
283
1.080
Why?
Altitude
4
2022
463
1.070
Why?
Lung
8
2026
4116
1.050
Why?
Iron
4
2025
359
1.040
Why?
Heme
3
2025
90
1.030
Why?
Pulmonary Edema
3
2019
105
1.020
Why?
Vascular Remodeling
4
2026
209
0.850
Why?
Muscle, Skeletal
4
2025
1791
0.800
Why?
Animals
41
2026
38102
0.760
Why?
Spleen
1
2025
508
0.740
Why?
Oxygen
5
2024
981
0.720
Why?
Pulmonary Ventilation
1
2022
82
0.720
Why?
Rats
17
2024
5585
0.680
Why?
Capillary Permeability
4
2016
132
0.650
Why?
Beta vulgaris
1
2020
14
0.640
Why?
Disease Models, Animal
14
2026
4568
0.630
Why?
Pulmonary Artery
6
2022
1129
0.620
Why?
Proteome
1
2025
513
0.620
Why?
Rats, Sprague-Dawley
12
2024
2525
0.610
Why?
Emulsions
1
2019
59
0.600
Why?
Atrial Natriuretic Factor
3
2005
55
0.600
Why?
Endothelium, Vascular
3
2018
956
0.590
Why?
Macrophages
3
2026
1507
0.590
Why?
Vasodilator Agents
2
2013
330
0.590
Why?
Blood Substitutes
2
2009
27
0.570
Why?
Reactive Oxygen Species
2
2013
611
0.550
Why?
Fluorocarbons
1
2019
120
0.540
Why?
Mice
19
2026
18356
0.540
Why?
Oxygen Consumption
3
2024
719
0.520
Why?
Physical Exertion
1
2018
205
0.510
Why?
Carbonic Anhydrase Inhibitors
1
2016
14
0.500
Why?
Cerebral Veins
1
2016
16
0.490
Why?
Toll-Like Receptor 9
1
2017
37
0.490
Why?
Angiogenesis Inducing Agents
1
2016
25
0.490
Why?
Microvessels
1
2018
97
0.490
Why?
Brain Edema
1
2016
62
0.480
Why?
Water
1
2019
448
0.480
Why?
Cerebral Arteries
1
2016
59
0.480
Why?
Liver
1
2025
1899
0.470
Why?
Drug Delivery Systems
1
2019
381
0.470
Why?
NF-E2-Related Factor 2
2
2013
101
0.450
Why?
Muscle Contraction
1
2018
429
0.440
Why?
Angiogenesis Inhibitors
1
2016
239
0.430
Why?
Exercise
2
2024
2205
0.420
Why?
Transcriptional Activation
2
2013
372
0.400
Why?
Endothelial Cells
2
2013
878
0.390
Why?
Vascular Diseases
2
2015
252
0.390
Why?
Mice, Inbred C57BL
6
2025
5993
0.370
Why?
Myeloid Differentiation Factor 88
1
2013
119
0.370
Why?
Anemia, Hemolytic
2
2026
21
0.370
Why?
Inflammation
4
2026
2884
0.360
Why?
Hypoxia-Inducible Factor 1, alpha Subunit
3
2014
298
0.350
Why?
Oxidative Stress
5
2026
1360
0.320
Why?
Glutaral
1
2009
14
0.300
Why?
Lung Diseases
2
2015
782
0.290
Why?
Male
21
2026
73011
0.290
Why?
Phosphodiesterase Inhibitors
1
2009
73
0.290
Why?
Phosphodiesterase 5 Inhibitors
1
2009
40
0.290
Why?
Proteomics
3
2025
1188
0.290
Why?
Phenylpropionates
2
2019
27
0.280
Why?
Sulfones
1
2009
127
0.280
Why?
Pyridazines
2
2019
57
0.280
Why?
Vascular Resistance
3
2016
370
0.270
Why?
Endothelins
2
2018
61
0.270
Why?
Disease Progression
3
2023
2865
0.260
Why?
Polymers
2
2009
485
0.260
Why?
Humans
27
2026
145783
0.250
Why?
Nitric Oxide
3
2018
892
0.250
Why?
Piperazines
1
2009
375
0.240
Why?
Lipid Peroxidation
3
2018
168
0.240
Why?
Respiration
2
2022
207
0.240
Why?
Vascular Endothelial Growth Factor A
1
2009
552
0.240
Why?
Extracorporeal Circulation
1
2026
14
0.240
Why?
Cell Nucleus
1
2009
588
0.230
Why?
Physical Conditioning, Animal
2
2025
242
0.230
Why?
Transferrin
1
2025
50
0.220
Why?
Blood Pressure
5
2018
1782
0.220
Why?
Muscle, Smooth, Vascular
4
2017
450
0.220
Why?
Capillary Leak Syndrome
1
2005
12
0.220
Why?
Cardiac Output
3
2012
179
0.220
Why?
Cation Transport Proteins
1
2026
118
0.220
Why?
Lignans
1
2024
12
0.220
Why?
Glucosephosphate Dehydrogenase Deficiency
1
2025
34
0.210
Why?
Neprilysin
1
2005
47
0.210
Why?
Heme Oxygenase-1
1
2025
76
0.210
Why?
Biphenyl Compounds
1
2024
67
0.210
Why?
Glucosephosphate Dehydrogenase
1
2025
70
0.210
Why?
NAD
1
2024
79
0.210
Why?
Aerosols
1
2025
146
0.210
Why?
Sirtuin 3
1
2024
60
0.200
Why?
Intercellular Adhesion Molecule-1
2
2015
132
0.190
Why?
Endothelin-1
1
2005
181
0.190
Why?
Ventricular Function, Right
1
2025
297
0.190
Why?
Glycolysis
1
2025
340
0.190
Why?
Pulmonary Circulation
2
2019
430
0.190
Why?
Oxidation-Reduction
3
2018
1069
0.180
Why?
Antibodies
2
2021
397
0.180
Why?
Oxyhemoglobins
1
2021
28
0.170
Why?
Magnetics
1
2021
46
0.170
Why?
Scleroderma, Systemic
1
2022
123
0.170
Why?
Leukocytes, Mononuclear
1
2023
574
0.160
Why?
Muscle Proteins
1
2022
243
0.160
Why?
Monocytes
1
2023
539
0.160
Why?
Metabolic Diseases
1
2021
114
0.160
Why?
CD40 Antigens
1
2021
90
0.160
Why?
Extracellular Vesicles
1
2023
171
0.160
Why?
RNA, Long Noncoding
1
2022
172
0.150
Why?
Up-Regulation
2
2013
848
0.150
Why?
Alternative Splicing
1
2022
248
0.150
Why?
Endotoxins
1
2001
217
0.150
Why?
Histone Deacetylases
2
2012
207
0.150
Why?
Nitrates
1
2020
96
0.150
Why?
Phenotype
2
2026
3170
0.150
Why?
Receptors, G-Protein-Coupled
1
2021
231
0.150
Why?
Gadolinium
1
2019
84
0.140
Why?
Drug Evaluation, Preclinical
1
2019
196
0.140
Why?
Enoyl-CoA Hydratase
1
2018
12
0.140
Why?
Cell Line
2
2015
2823
0.140
Why?
Carrier Proteins
1
2022
729
0.140
Why?
Blood Gas Analysis
2
2008
82
0.140
Why?
Metabolome
1
2021
391
0.130
Why?
Double-Blind Method
2
2020
2064
0.130
Why?
Aminophylline
1
2017
12
0.130
Why?
Liver Diseases
1
2021
305
0.130
Why?
Antioxidants
2
2013
550
0.130
Why?
Lipids
2
2023
707
0.130
Why?
Cells, Cultured
6
2014
4151
0.130
Why?
Lipoproteins
1
2018
166
0.130
Why?
Deferoxamine
1
2016
27
0.120
Why?
Cell Proliferation
2
2017
2514
0.120
Why?
Acetazolamide
1
2016
26
0.120
Why?
Acclimatization
1
2018
170
0.120
Why?
Mice, Knockout
3
2022
3130
0.120
Why?
NF-kappa B
2
2013
667
0.120
Why?
Dietary Supplements
1
2020
584
0.120
Why?
Niacinamide
1
2016
104
0.120
Why?
Oligonucleotides
1
2016
153
0.110
Why?
Myocytes, Cardiac
3
2022
546
0.110
Why?
Cardiomyopathy, Dilated
1
2018
356
0.110
Why?
Methemoglobin
2
2021
24
0.110
Why?
Antihypertensive Agents
1
2019
521
0.110
Why?
Vasoconstriction
1
2016
216
0.110
Why?
Signal Transduction
5
2017
5224
0.110
Why?
Hypertrophy, Right Ventricular
1
2015
149
0.100
Why?
Cattle
2
2008
946
0.100
Why?
Chloride Channels
1
2014
33
0.100
Why?
RNA, Small Interfering
3
2012
638
0.100
Why?
Catalase
1
2013
134
0.100
Why?
Cell Membrane Permeability
1
2013
88
0.100
Why?
Genomics
1
2018
830
0.100
Why?
Histone Deacetylase Inhibitors
2
2012
218
0.100
Why?
Permeability
1
2013
169
0.100
Why?
Indoles
1
2016
507
0.090
Why?
Ventricular Remodeling
2
2012
278
0.090
Why?
Interleukin-6
1
2017
780
0.090
Why?
Cyclic N-Oxides
1
2012
32
0.090
Why?
Infusion Pumps
1
2012
33
0.090
Why?
Spin Labels
1
2012
59
0.090
Why?
Macrophages, Alveolar
1
2015
373
0.090
Why?
Heart Failure
2
2022
2326
0.090
Why?
Mitochondrial Proteins
1
2014
263
0.090
Why?
Gene Expression Regulation, Enzymologic
1
2012
267
0.090
Why?
Superoxide Dismutase
1
2013
308
0.090
Why?
Toll-Like Receptor 4
1
2013
276
0.080
Why?
Cerebellum
1
2013
224
0.080
Why?
Cardiovascular Diseases
2
2021
2191
0.080
Why?
Hydrogen Peroxide
1
2012
335
0.080
Why?
Microcirculation
2
2014
142
0.080
Why?
Blotting, Western
1
2012
1184
0.080
Why?
Sildenafil Citrate
1
2009
60
0.070
Why?
Pneumonia
1
2015
636
0.070
Why?
Active Transport, Cell Nucleus
1
2009
117
0.070
Why?
Hypoxia, Brain
1
2008
9
0.070
Why?
NG-Nitroarginine Methyl Ester
1
2008
49
0.070
Why?
Purines
1
2009
187
0.070
Why?
Mice, Transgenic
2
2025
2191
0.070
Why?
Nitric Oxide Synthase
1
2008
234
0.070
Why?
Epinephrine
1
2008
158
0.060
Why?
Norepinephrine
1
2008
201
0.060
Why?
Hemodynamics
1
2012
1118
0.060
Why?
Female
7
2022
79045
0.060
Why?
Dogs
1
2008
478
0.060
Why?
Mesocricetus
1
2026
52
0.060
Why?
Protein Isoforms
2
2022
399
0.060
Why?
Myocardium
1
2011
935
0.060
Why?
Cricetinae
1
2026
305
0.060
Why?
RNA, Messenger
1
2013
2805
0.060
Why?
Stress Fibers
1
2004
18
0.050
Why?
Stroke Volume
1
2008
655
0.050
Why?
Allyl Compounds
1
2024
25
0.050
Why?
Enzyme Inhibitors
1
2008
821
0.050
Why?
Tissue Distribution
1
2025
335
0.050
Why?
Treatment Outcome
1
2019
11794
0.050
Why?
Kidney
1
2012
1497
0.050
Why?
Sirtuins
1
2024
50
0.050
Why?
Heart Rate
1
2008
856
0.050
Why?
Phenols
1
2024
106
0.050
Why?
p38 Mitogen-Activated Protein Kinases
1
2004
264
0.050
Why?
Actins
1
2004
426
0.050
Why?
Hypertension
1
2011
1276
0.040
Why?
Catecholamines
1
2022
88
0.040
Why?
RNA Splicing Factors
1
2022
66
0.040
Why?
Thrombin
1
2023
172
0.040
Why?
In Situ Hybridization, Fluorescence
1
2022
328
0.040
Why?
Lipopolysaccharides
1
2004
858
0.040
Why?
Lung Neoplasms
1
2014
2668
0.040
Why?
Etanercept
1
2021
60
0.040
Why?
Salmonella enteritidis
1
2001
16
0.040
Why?
Case-Control Studies
2
2018
3634
0.040
Why?
Tumor Necrosis Factor-alpha
1
2004
1217
0.040
Why?
Protein Binding
1
2026
2240
0.040
Why?
Ligands
1
2021
668
0.040
Why?
Arrhythmias, Cardiac
1
2022
356
0.040
Why?
Intracellular Signaling Peptides and Proteins
1
2022
457
0.040
Why?
Metabolomics
1
2025
733
0.040
Why?
Fatty Acids
1
2022
457
0.040
Why?
Erythrocytes
1
2025
749
0.040
Why?
Heart
1
2022
626
0.030
Why?
Guinea Pigs
1
2018
159
0.030
Why?
Linkage Disequilibrium
1
2018
255
0.030
Why?
Tissue Donors
1
2021
420
0.030
Why?
Ventricular Dysfunction, Right
1
2021
248
0.030
Why?
Inflammation Mediators
1
2021
507
0.030
Why?
Cytochrome P-450 Enzyme System
1
2018
162
0.030
Why?
Cytoskeleton
1
2018
192
0.030
Why?
Genetics, Population
1
2018
217
0.030
Why?
Proteins
1
2023
1023
0.030
Why?
Heart Ventricles
2
2012
756
0.030
Why?
Mice, Inbred Strains
2
2014
396
0.030
Why?
Sequence Analysis, RNA
1
2018
442
0.030
Why?
Gene Regulatory Networks
1
2018
318
0.030
Why?
Adenosine
1
2017
255
0.030
Why?
Sarcoma, Experimental
1
2014
6
0.030
Why?
Rats, Nude
1
2014
25
0.030
Why?
Intravital Microscopy
1
2014
24
0.030
Why?
Drug Therapy, Combination
1
2017
1043
0.030
Why?
Heterografts
1
2014
143
0.030
Why?
Models, Biological
1
2021
1764
0.030
Why?
Coronary Vessels
1
2016
246
0.030
Why?
Genotype
1
2018
1857
0.020
Why?
Transcription Factor RelA
1
2014
86
0.020
Why?
Swine
1
2016
826
0.020
Why?
Familial Primary Pulmonary Hypertension
1
2014
196
0.020
Why?
Blood Flow Velocity
1
2014
421
0.020
Why?
Cytokines
1
2021
2069
0.020
Why?
Neovascularization, Pathologic
1
2014
287
0.020
Why?
Chemistry, Physical
1
2012
37
0.020
Why?
Fructans
1
1992
1
0.020
Why?
Genes, Immunoglobulin
1
1992
29
0.020
Why?
MicroRNAs
1
2018
686
0.020
Why?
Immunoglobulin Variable Region
1
1992
80
0.020
Why?
Immunoglobulin Light Chains
1
1992
52
0.020
Why?
Immunoglobulin Heavy Chains
1
1992
86
0.020
Why?
Adult
3
2023
40881
0.020
Why?
Mitochondria
1
2018
993
0.020
Why?
Gene Expression Profiling
1
2018
1777
0.020
Why?
Histone Deacetylase 6
1
2011
17
0.020
Why?
Polymorphism, Single Nucleotide
1
2018
2181
0.020
Why?
Young Adult
2
2018
14254
0.020
Why?
Benzamides
1
2012
226
0.020
Why?
Adenoviridae
1
2011
199
0.020
Why?
Regional Blood Flow
1
2012
514
0.020
Why?
RNA Interference
1
2011
475
0.020
Why?
Pyrimidines
1
2012
530
0.020
Why?
Polymerase Chain Reaction
1
2011
1043
0.020
Why?
Cohort Studies
1
2018
6033
0.020
Why?
Pyridines
1
2012
609
0.020
Why?
Cell Line, Tumor
1
2014
3551
0.020
Why?
Middle Aged
2
2018
36309
0.010
Why?
Antibodies, Monoclonal
1
1992
1505
0.010
Why?
Child
1
2023
22740
0.010
Why?
Breast Neoplasms
1
2014
2393
0.010
Why?
Adolescent
1
2017
22577
0.010
Why?
Antibody Diversity
1
1992
16
0.010
Why?
Immunoglobulin Isotypes
1
1992
36
0.010
Why?
Antibody Specificity
1
1992
179
0.010
Why?
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