 Toll-Like Receptor 4
"Toll-Like Receptor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
| Descriptor ID |
D051197
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| MeSH Number(s) |
D12.776.543.750.705.910.500.400
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| Concept/Terms |
Toll-Like Receptor 4- Toll-Like Receptor 4
- Toll Like Receptor 4
- Toll-4 Receptor
- Toll 4 Receptor
- TLR4 Receptor
- Receptor, TLR4
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Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 4".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 4".
This graph shows the total number of publications written about "Toll-Like Receptor 4" by people in this website by year, and whether "Toll-Like Receptor 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2001 | 0 | 5 | 5 | | 2002 | 0 | 9 | 9 | | 2003 | 0 | 2 | 2 | | 2004 | 1 | 10 | 11 | | 2005 | 3 | 6 | 9 | | 2006 | 3 | 1 | 4 | | 2007 | 4 | 5 | 9 | | 2008 | 7 | 3 | 10 | | 2009 | 12 | 6 | 18 | | 2010 | 7 | 4 | 11 | | 2011 | 6 | 3 | 9 | | 2012 | 7 | 7 | 14 | | 2013 | 7 | 7 | 14 | | 2014 | 14 | 5 | 19 | | 2015 | 10 | 4 | 14 | | 2016 | 6 | 3 | 9 | | 2017 | 3 | 6 | 9 | | 2018 | 4 | 0 | 4 | | 2019 | 3 | 3 | 6 | | 2020 | 3 | 6 | 9 | | 2021 | 2 | 2 | 4 | | 2022 | 1 | 1 | 2 | | 2023 | 2 | 2 | 4 | | 2024 | 1 | 2 | 3 | | 2025 | 2 | 1 | 3 |
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Below are the most recent publications written about "Toll-Like Receptor 4" by people in Profiles.
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Thompson BJ, Carillion EL, Alper S, Bryant SJ. The foreign body response to biomaterial implants is reduced by co-inhibition of TLR2 and TLR4. Acta Biomater. 2025 Jul 01; 201:320-335.
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Thompson BJ, Saleh LS, Carillion EL, Alper S, Bryant SJ. Damage Associated Molecular Patterns (DAMPs) Mediate the Foreign Body Response to Poly(ethylene glycol) Diacrylate Hydrogels via Toll like Receptors. ACS Biomater Sci Eng. 2025 Jul 14; 11(7):4128-4138.
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Kroon S, Malcic D, Weidert L, Bircher L, Boldt L, Christen P, Kiefer P, Sintsova A, Nguyen BD, Barthel M, Steiger Y, Clerc M, Herzog MK, Chen C, Gül E, Guery B, Slack E, Sunagawa S, Vorholt JA, Maier L, Lacroix C, Hausmann A, Hardt WD. Sublethal systemic LPS in mice enables gut-luminal pathogens to bloom through oxygen species-mediated microbiota inhibition. Nat Commun. 2025 Mar 20; 16(1):2760.
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Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nat Commun. 2024 May 18; 15(1):4235.
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Pokharel MD, Fu P, Garcia-Flores A, Yegambaram M, Lu Q, Sun X, Unwalla H, Aggarwal S, Fineman JR, Wang T, Black SM. Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling. Free Radic Biol Med. 2024 Aug 20; 221:125-135.
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Timkovich AE, Holling GA, Afzali MF, Kisiday J, Santangelo KS. TLR4 antagonism provides short-term but not long-term clinical benefit in a full-depth cartilage defect mouse model. Connect Tissue Res. 2024 01; 65(1):26-40.
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Rana R, Manoharan J, Elwakiel A, Zimmermann S, Lindquist JA, Gupta D, Al-Dabet MM, Gadi I, Fallmann J, Singh K, Gupta A, Biemann R, Brandt S, Alo B, Kluge P, Garde R, Lamers C, Shahzad K, Künze G, Kohli S, Mertens PR, Isermann B. Glomerular-tubular crosstalk via cold shock Y-box binding protein-1 in the kidney. Kidney Int. 2024 01; 105(1):65-83.
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Brown KT, Levis SC, O'Neill CE, Levy C, Rice KC, Watkins LR, Bachtell RK. Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking. Psychopharmacology (Berl). 2023 Jul; 240(7):1587-1600.
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Ermisch AF, Bidne KL, Kurz SG, Bochantin KA, Wood JR. Ovarian inflammation mediated by Toll-like receptor 4 increased transcripts of maternal effect genes and decreased embryo development?. Biol Reprod. 2023 03 13; 108(3):423-436.
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Glaser K, Kern D, Speer CP, Schlegel N, Schwab M, Thome UH, H?rtel C, Wright CJ. Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14+CD16+ Subset upon Toll-like Receptor Stimulation. Int J Mol Sci. 2023 Mar 03; 24(5).
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