 Blood Substitutes
"Blood Substitutes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
| Descriptor ID |
D001802
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| MeSH Number(s) |
D27.505.954.502.140 J01.637.087.249
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| Concept/Terms |
Blood Substitutes- Blood Substitutes
- Blood Substitute
- Substitute, Blood
- Substitutes, Blood
- Artificial Blood
- Artificial Bloods
- Bloods, Artificial
- Blood, Artificial
Artificial Erythrocytes- Artificial Erythrocytes
- Artificial Erythrocyte
- Erythrocyte, Artificial
- Erythrocytes, Artificial
- Red Cell Substitutes
- Cell Substitute, Red
- Cell Substitutes, Red
- Red Cell Substitute
- Substitute, Red Cell
- Substitutes, Red Cell
- Erythrocyte Substitutes
- Erythrocyte Substitute
- Substitute, Erythrocyte
- Substitutes, Erythrocyte
Artificial Hemoglobin- Artificial Hemoglobin
- Artificial Hemoglobins
- Hemoglobin, Artificial
- Hemoglobins, Artificial
- Hemoglobin Substitutes
- Hemoglobin Substitute
- Substitute, Hemoglobin
- Substitutes, Hemoglobin
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Below are MeSH descriptors whose meaning is more general than "Blood Substitutes".
Below are MeSH descriptors whose meaning is more specific than "Blood Substitutes".
This graph shows the total number of publications written about "Blood Substitutes" by people in this website by year, and whether "Blood Substitutes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 2 | 1 | 3 | | 2006 | 1 | 1 | 2 | | 2007 | 3 | 0 | 3 | | 2008 | 4 | 0 | 4 | | 2009 | 3 | 0 | 3 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Blood Substitutes" by people in Profiles.
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Tan GM, Guinn NR, Frank SM, Shander A. Proceedings From the Society for Advancement of Blood Management Annual Meeting 2017: Management Dilemmas of the Surgical Patient-When Blood Is Not an Option. Anesth Analg. 2019 01; 128(1):144-151.
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Morton AP, Moore EE, Moore HB, Gonzalez E, Chapman MP, Peltz E, Banerjee A, Silliman C. Hemoglobin-based oxygen carriers promote systemic hyperfibrinolysis that is both dependent and independent of plasmin. J Surg Res. 2017 06 01; 213:166-170.
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Lo KK, Bey EA, Patra B, Benson DD, Boothman DA, Silliman CC, Barnett CC. Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression. Ann Surg Oncol. 2013 Jun; 20(6):2073-7.
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Baek JH, Zhou Y, Harris DR, Schaer DJ, Palmer AF, Buehler PW. Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicol Sci. 2012 Jun; 127(2):567-81.
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Buehler PW, D'Agnillo F, Schaer DJ. Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med. 2010 Oct; 16(10):447-57.
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Gotshall RW, Hamilton KL, Foreman B, van Patot MC, Irwin DC. Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition. Crit Care Med. 2009 Jun; 37(6):1988-93.
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Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):200-9.
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Moore EE, Johnson JL, Moore FA, Moore HB. The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: scientific rationale, study design, and results. Crit Care Clin. 2009 Apr; 25(2):325-56, Table of Contents.
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Roach JP, Moore EE, Partrick DA, Damle SS, Silliman CC, McIntyre RC, Banerjee A. Heme oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion. Shock. 2009 Mar; 31(3):251-7.
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Sauaia A, Moore EE, Banerjee A. Hemoglobin-based blood substitutes and risk of myocardial infarction and death. JAMA. 2008 Sep 17; 300(11):1297; author reply 1298-9.
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