Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
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Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 1 | 2 | 1996 | 0 | 3 | 3 | 1997 | 0 | 1 | 1 | 1998 | 4 | 2 | 6 | 1999 | 2 | 1 | 3 | 2000 | 4 | 1 | 5 | 2001 | 0 | 2 | 2 | 2002 | 2 | 3 | 5 | 2003 | 4 | 3 | 7 | 2004 | 1 | 3 | 4 | 2005 | 1 | 4 | 5 | 2006 | 6 | 4 | 10 | 2007 | 1 | 2 | 3 | 2008 | 2 | 1 | 3 | 2009 | 3 | 1 | 4 | 2010 | 2 | 2 | 4 | 2011 | 0 | 2 | 2 | 2013 | 4 | 5 | 9 | 2014 | 1 | 3 | 4 | 2015 | 3 | 2 | 5 | 2016 | 4 | 3 | 7 | 2017 | 2 | 4 | 6 | 2018 | 4 | 3 | 7 | 2019 | 4 | 4 | 8 | 2020 | 1 | 6 | 7 | 2021 | 5 | 2 | 7 | 2022 | 1 | 2 | 3 | 2023 | 2 | 1 | 3 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen LL, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. Cell. 2024 Dec 26; 187(26):7621-7636.e19.
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Innes PA, Goebl AM, Smith CCR, Rosenberger K, Kane NC. Gene expression and alternative splicing contribute to adaptive divergence of ecotypes. Heredity (Edinb). 2024 03; 132(3):120-132.
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Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25; 14(1):7732.
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Gotthardt M, Badillo-Lisakowski V, Parikh VN, Ashley E, Furtado M, Carmo-Fonseca M, Schudy S, Meder B, Grosch M, Steinmetz L, Crocini C, Leinwand L. Cardiac splicing as a diagnostic and therapeutic target. Nat Rev Cardiol. 2023 08; 20(8):517-530.
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Han Y, Wennersten SA, Wright JM, Ludwig RW, Lau E, Lam MPY. Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging. Am J Physiol Heart Circ Physiol. 2022 09 01; 323(3):H538-H558.
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Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 08 30; 146(9):699-714.
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Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, Adams JS, Chun R. Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight. Skelet Muscle. 2022 05 31; 12(1):11.
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Carranza F, Shenasa H, Hertel KJ. Splice site proximity influences alternative exon definition. RNA Biol. 2022 01; 19(1):829-840.
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Kim SP, Srivatsan SN, Chavez M, Shirai CL, White BS, Ahmed T, Alberti MO, Shao J, Nunley R, White LS, Bednarski J, Pehrson JR, Walter MJ. Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice. Cell Rep. 2021 08 31; 36(9):109626.
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Dennison BJC, Larson ED, Fu R, Mo J, Fantauzzo KA. Srsf3 mediates alternative RNA splicing downstream of PDGFRa signaling in the facial mesenchyme. Development. 2021 07 15; 148(14).
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