Alternative Splicing
"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Descriptor ID |
D017398
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MeSH Number(s) |
G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
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Concept/Terms |
Alternative Splicing- Alternative Splicing
- Alternative Splicings
- Splicings, Alternative
- Alternate Splicing
- Alternate Splicings
- Splicing, Alternate
- Splicings, Alternate
- RNA Splicing, Alternative
- Alternative RNA Splicing
- Alternative RNA Splicings
- RNA Splicings, Alternative
- Splicing, Alternative RNA
- Splicings, Alternative RNA
- Splicing, Alternative
Nested Transcripts- Nested Transcripts
- Nested Transcript
- Transcript, Nested
- Transcripts, Nested
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Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".
Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".
This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 1 | 2 | 1996 | 0 | 3 | 3 | 1997 | 0 | 1 | 1 | 1998 | 3 | 3 | 6 | 1999 | 2 | 1 | 3 | 2000 | 4 | 1 | 5 | 2001 | 0 | 4 | 4 | 2002 | 2 | 5 | 7 | 2003 | 4 | 3 | 7 | 2004 | 1 | 3 | 4 | 2005 | 1 | 4 | 5 | 2006 | 6 | 4 | 10 | 2007 | 1 | 2 | 3 | 2008 | 2 | 1 | 3 | 2009 | 3 | 1 | 4 | 2010 | 3 | 2 | 5 | 2011 | 0 | 2 | 2 | 2013 | 4 | 7 | 11 | 2014 | 2 | 3 | 5 | 2015 | 3 | 2 | 5 | 2016 | 4 | 3 | 7 | 2017 | 2 | 4 | 6 | 2018 | 6 | 3 | 9 | 2019 | 4 | 4 | 8 | 2020 | 1 | 5 | 6 | 2021 | 5 | 2 | 7 | 2022 | 1 | 2 | 3 | 2023 | 2 | 1 | 3 | 2024 | 6 | 0 | 6 | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Alternative Splicing" by people in Profiles.
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Voss DM, Kral AJ, Sim G, Utama R, Lin KT, Cizmeciyan C, Schafer B, Cunniff PJ, Vakoc CR, Caruthers MH, Mishra L, Krainer AR. PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma. J Biol Chem. 2025 Apr; 301(4):108345.
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Elling CL, Ryan AF, Yarza TKL, Ghaffar A, Llanes EGDV, Kofonow JM, Reyes-Quintos MRT, Riazuddin S, Robertson CE, Tantoco MLC, Ahmed ZM, Chan AL, Frank DN, Chiong CM, Santos-Cortez RLP. A Novel SLPI Splice Variant Confers Susceptibility to Otitis Media in Humans. Int J Mol Sci. 2025 Feb 07; 26(4).
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Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen LL, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB. Regulation of human interferon signaling by transposon exonization. Cell. 2024 Dec 26; 187(26):7621-7636.e19.
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Ueda MT, Inamo J, Miya F, Shimada M, Yamaguchi K, Kochi Y. Functional and dynamic profiling of transcript isoforms reveals essential roles of alternative splicing in interferon response. Cell Genom. 2024 Oct 09; 4(10):100654.
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Inamo J, Suzuki A, Ueda MT, Yamaguchi K, Nishida H, Suzuki K, Kaneko Y, Takeuchi T, Hatano H, Ishigaki K, Ishihama Y, Yamamoto K, Kochi Y. Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms. Nat Commun. 2024 May 28; 15(1):4285.
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Wan L, Kral AJ, Voss D, Sch?fer B, Sudheendran K, Danielsen M, Caruthers MH, Krainer AR. Screening Splice-Switching Antisense Oligonucleotides in Pancreas-Cancer Organoids. Nucleic Acid Ther. 2024 08; 34(4):188-198.
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Pandi B, Brenman S, Black A, Ng DCM, Lau E, Lam MPY. Tissue Usage Preference and Intrinsically Disordered Region Remodeling of Alternative Splicing Derived Proteoforms in the Heart. J Proteome Res. 2024 Aug 02; 23(8):3161-3173.
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Lee FFY, Harris C, Alper S. RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator. J Mol Biol. 2024 Apr 15; 436(8):168497.
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Innes PA, Goebl AM, Smith CCR, Rosenberger K, Kane NC. Gene expression and alternative splicing contribute to adaptive divergence of ecotypes. Heredity (Edinb). 2024 03; 132(3):120-132.
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Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 11 25; 14(1):7732.
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