 Interleukin-6
"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
| Descriptor ID |
D015850
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| MeSH Number(s) |
D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
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| Concept/Terms |
Interleukin-6- Interleukin-6
- Interleukin 6
- IL6
- B-Cell Stimulatory Factor 2
- B-Cell Stimulatory Factor-2
- Differentiation Factor-2, B-Cell
- Differentiation Factor 2, B Cell
- B-Cell Differentiation Factor-2
- B Cell Differentiation Factor 2
- BSF-2
- Hybridoma Growth Factor
- Growth Factor, Hybridoma
- IFN-beta 2
- Plasmacytoma Growth Factor
- Growth Factor, Plasmacytoma
- Hepatocyte-Stimulating Factor
- Hepatocyte Stimulating Factor
- MGI-2
- Myeloid Differentiation-Inducing Protein
- Differentiation-Inducing Protein, Myeloid
- Myeloid Differentiation Inducing Protein
- B-Cell Differentiation Factor
- B Cell Differentiation Factor
- Differentiation Factor, B-Cell
- Differentiation Factor, B Cell
- IL-6
- Interferon beta-2
- Interferon beta 2
- beta-2, Interferon
- B Cell Stimulatory Factor-2
- B Cell Stimulatory Factor 2
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Below are MeSH descriptors whose meaning is more general than "Interleukin-6".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".
This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 3 | 7 | | 1997 | 4 | 8 | 12 | | 1998 | 4 | 7 | 11 | | 1999 | 5 | 7 | 12 | | 2000 | 2 | 2 | 4 | | 2001 | 2 | 5 | 7 | | 2002 | 0 | 12 | 12 | | 2003 | 2 | 10 | 12 | | 2004 | 5 | 7 | 12 | | 2005 | 1 | 11 | 12 | | 2006 | 6 | 11 | 17 | | 2007 | 9 | 10 | 19 | | 2008 | 6 | 16 | 22 | | 2009 | 9 | 21 | 30 | | 2010 | 8 | 10 | 18 | | 2011 | 4 | 15 | 19 | | 2012 | 8 | 15 | 23 | | 2013 | 6 | 17 | 23 | | 2014 | 6 | 21 | 27 | | 2015 | 4 | 12 | 16 | | 2016 | 4 | 13 | 17 | | 2017 | 4 | 6 | 10 | | 2018 | 5 | 12 | 17 | | 2019 | 4 | 10 | 14 | | 2020 | 11 | 13 | 24 | | 2021 | 8 | 11 | 19 | | 2022 | 8 | 14 | 22 | | 2023 | 3 | 15 | 18 | | 2024 | 6 | 6 | 12 | | 2025 | 4 | 12 | 16 | | 2026 | 1 | 6 | 7 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-6" by people in Profiles.
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Files DC, Matthay MA, Chapple AG, Barragan AB, Mabrey L, Gibbs KW, Krall J, Aggarwal NR, Burnham EL, Liu KD, Meyer NJ, Nates JL, Youssef FA, Friedman E, Kett DH, Koff J, Russell DW, Calfee CS, Eklund M, Esserman LJ. Biological subphenotypes in severe acute hypoxaemic respiratory failure and acute respiratory distress syndrome using rapid prospective classification (SPARC) in the USA: a multicentre, observational, study. Lancet Respir Med. 2026 Jul; 14(7):601-608.
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Bettcher BM, Ren S, Wang Y, Carlson NE, Lippitt WL, McConnell BV, Wilson EN, Shapiro ALB, Coughlan C, Carlisle TC, Unger JR, Cook GG, Bengtson K, Gorla L, Ueberheide BM, Kanshin E, Potter H, Schulz L, Frazer-Abel A, Pelak VS. Relation of blood-based inflammation conditional networks to key immune health status and Alzheimer's biomarkers in aging adults. Neurobiol Aging. 2026 Oct; 166:14-28.
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Owens JM, Weppner HK, Ignes-Romeu A, Burleson JW, Hind LE. Interleukin-6 regulates the neutrophil response to diverse bacteria. Front Immunol. 2026; 17:1783843.
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Counts BR, Bonetto A, Chan HL, Au ED, Jiang Y, Couch ME, Guttridge DC, Ostrowski MC, Koniaris LG, Zimmers TA. High-fat diet and obesity each increase tumor cell proliferation and muscle wasting in experimental cancer cachexia. Am J Physiol Cell Physiol. 2026 04 01; 330(4):C727-C740.
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Oshima K, Yan B, Tao R, Amorim G, Di Gravio C, McMurtry SA, Burke RC, Nam Y, Nikolli I, Kravitz MS, Stephenson D, Issaian A, Hansen KC, D'Alessandro A, Douglas IS, Self WH, Lindsell CJ, Leroux C, Ringor A, Matthay MA, Schildcrout JS, Shapiro NI, Schmidt EP. Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis. J Clin Invest. 2026 04 01; 136(7).
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Moran M, Salmon K, Dhaliwal SK, Dabelea D, Perng W. Associations of Maternal Prenatal Inflammation With Child Adiposity: The Healthy Start Study. Pediatr Obes. 2026 Feb; 21(2):e70088.
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Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T. Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. Microbiol Immunol. 2026 Mar; 70(3):148-159.
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Takahashi K, Yamakawa K, Siletz AE, Katsura M, Holcomb JB, Cotton BA, Wade CE, Cardenas JC, Martin M, Inaba K, Matsushima K. Hyperfibrinolysis in trauma-induced coagulopathy: exploring the role of inflammatory cytokines. J Thromb Haemost. 2026 Jun; 24(6):2235-2242.
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Singh S, Singh AK, Singh AN, Singh SK, Yadav VB, Gangwar M, Sahu M, Kumar D, Nath G. Efficacy of bacteriophage cocktails administered through mucosal and non-mucosal routes for urinary tract infections caused by Enterobacter cloacae: A preclinical study. Microb Pathog. 2025 Dec; 209:108024.
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Scharf G, Davidson CR, Ustiyan V, Falkenberg LG, Adavalli A, Meeker JD, Morgan H, Ostmann AJ, Hudock KM, Brewington JJ, Clancy JP, Kramer EL. TGF-ß induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. Am J Physiol Lung Cell Mol Physiol. 2025 10 01; 329(4):L470-L479.
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