 Interleukin-6
"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
| Descriptor ID |
D015850
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| MeSH Number(s) |
D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
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| Concept/Terms |
Interleukin-6- Interleukin-6
- Interleukin 6
- IL6
- B-Cell Stimulatory Factor 2
- B-Cell Stimulatory Factor-2
- Differentiation Factor-2, B-Cell
- Differentiation Factor 2, B Cell
- B-Cell Differentiation Factor-2
- B Cell Differentiation Factor 2
- BSF-2
- Hybridoma Growth Factor
- Growth Factor, Hybridoma
- IFN-beta 2
- Plasmacytoma Growth Factor
- Growth Factor, Plasmacytoma
- Hepatocyte-Stimulating Factor
- Hepatocyte Stimulating Factor
- MGI-2
- Myeloid Differentiation-Inducing Protein
- Differentiation-Inducing Protein, Myeloid
- Myeloid Differentiation Inducing Protein
- B-Cell Differentiation Factor
- B Cell Differentiation Factor
- Differentiation Factor, B-Cell
- Differentiation Factor, B Cell
- IL-6
- Interferon beta-2
- Interferon beta 2
- beta-2, Interferon
- B Cell Stimulatory Factor-2
- B Cell Stimulatory Factor 2
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Below are MeSH descriptors whose meaning is more general than "Interleukin-6".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".
This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 2 | 7 | | 1996 | 4 | 3 | 7 | | 1997 | 4 | 6 | 10 | | 1998 | 4 | 7 | 11 | | 1999 | 7 | 7 | 14 | | 2000 | 3 | 2 | 5 | | 2001 | 3 | 5 | 8 | | 2002 | 0 | 12 | 12 | | 2003 | 2 | 11 | 13 | | 2004 | 6 | 7 | 13 | | 2005 | 1 | 12 | 13 | | 2006 | 6 | 11 | 17 | | 2007 | 10 | 8 | 18 | | 2008 | 6 | 15 | 21 | | 2009 | 7 | 21 | 28 | | 2010 | 7 | 9 | 16 | | 2011 | 4 | 14 | 18 | | 2012 | 6 | 12 | 18 | | 2013 | 4 | 15 | 19 | | 2014 | 6 | 22 | 28 | | 2015 | 4 | 11 | 15 | | 2016 | 3 | 14 | 17 | | 2017 | 4 | 4 | 8 | | 2018 | 6 | 11 | 17 | | 2019 | 3 | 9 | 12 | | 2020 | 10 | 13 | 23 | | 2021 | 8 | 9 | 17 | | 2022 | 7 | 11 | 18 | | 2023 | 4 | 14 | 18 | | 2024 | 5 | 6 | 11 | | 2025 | 1 | 4 | 5 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-6" by people in Profiles.
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Gong J, Chan KS, Rajesh A, Droho S, Lavine JA. Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):43.
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Jiang Y, Brinck EA, Ascienzo S, Groves A, Trang K, Farewell CV. Child Maltreatment and Whole-person Health: Investigation of Psychosocial Buffers Using Structural Equation Modeling. Biopsychosoc Sci Med. 2025 Jun 01; 87(5):338-348.
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Bishop B, Webber WS, Atif SM, Ley A, Pankratz KA, Kostelecky R, Colgan SP, Dinarello CA, Zhang W, Li S. Micro- and nano-plastics induce inflammation and cell death in human cells. Front Immunol. 2025; 16:1528502.
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Li X, Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Yu KJ, Meng X. Aging Impairs the Capacity of Cardiac Functional Recovery Following Endotoxemia: Modulation of Myocardial Klotho Level for Remedy. J Surg Res. 2025 May; 309:25-36.
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Levy MV, Fandl HK, Hijmans JG, Stockelman KA, Ruzzene ST, Reiakvam WR, Goldthwaite ZA, Greiner JJ, DeSouza CA, Garcia VP. Effect of 17?-Estradiol on Endothelial Cell Expression of Inflammation- Related MicroRNA. Microrna. 2025; 14(1):3-8.
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Garcia VP, Stockelman KA, Levy MV, Fandl HK, Goulding A, Hijmans JG, Ruzzene ST, Berry AR, Greiner JJ, DeSouza CA. Microvesicles Derived from Nitric Oxide Synthase-Inhibited Endothelial Cells Promote Cell Dysfunction. J Vasc Res. 2025; 62(1):10-21.
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Brooks K, Nelson CE, Aguilar C, Hoang TN, Ortiz AM, Langner CA, Yee DS, Flynn JK, Vrba S, Laidlaw E, Vannella KM, Grazioli A, Saharia KK, Purcell M, Singireddy S, Wu J, Stankiewicz J, Chertow DS, Sereti I, Paiardini M, Hickman HD, Via LE, Barber DL, Brenchley JM. SARS-CoV-2 infection perturbs the gastrointestinal tract and induces modest microbial translocation across the intestinal barrier. J Virol. 2024 Oct 22; 98(10):e0128824.
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Saper VE, Tian L, Verstegen RHJ, Conrad CK, Cidon M, Hopper RK, Kuo CS, Osoegawa K, Baszis K, Bingham CA, Ferguson I, Hahn T, Horne A, Isupova EA, Jones JT, Kasapcopur ?, Klein-Gitelman MS, Kostik MM, Ozen S, Phadke O, Prahalad S, Randell RL, Sener S, Stingl C, Abdul-Aziz R, Akoghlanian S, Al Julandani D, Alvarez MB, Bader-Meunier B, Balay-Dustrude EE, Balboni I, Baxter SK, Berard RA, Bhattad S, Bolaria R, Boneparth A, Cassidy EA, Co DO, Collins KP, Dancey P, Dickinson AM, Edelheit BS, Espada G, Flanagan ER, Imundo LF, Jindal AK, Kim HA, Klaus G, Lake C, Lapin WB, Lawson EF, Marmor I, Mombourquette J, Ogunjimi B, Olveda R, Ombrello MJ, Onel K, Poholek C, Ramanan AV, Ravelli A, Reinhardt A, Robinson AD, Rouster-Stevens K, Saad N, Schneider R, Selmanovic V, Sefic Pasic I, Shenoi S, Shilo NR, Soep JB, Sura A, Taber SF, Tesher M, Tibaldi J, Torok KS, Tsin CM, Vasquez-Canizares N, Villacis Nunez DS, Way EE, Whitehead B, Zemel LS, Sharma S, Fern?ndez-Vi?a MA, Mellins ED. Interleukin (IL)-1/IL-6-Inhibitor-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses. J Allergy Clin Immunol Pract. 2024 Nov; 12(11):2996-3013.e7.
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Jiang MZ, Gaynor SM, Li X, Van Buren E, Stilp A, Buth E, Wang FF, Manansala R, Gogarten SM, Li Z, Polfus LM, Salimi S, Bis JC, Pankratz N, Yanek LR, Durda P, Tracy RP, Rich SS, Rotter JI, Mitchell BD, Lewis JP, Psaty BM, Pratte KA, Silverman EK, Kaplan RC, Avery C, North KE, Mathias RA, Faraday N, Lin H, Wang B, Carson AP, Norwood AF, Gibbs RA, Kooperberg C, Lundin J, Peters U, Dupuis J, Hou L, Fornage M, Benjamin EJ, Reiner AP, Bowler RP, Lin X, Auer PL, Raffield LM. Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium. Hum Mol Genet. 2024 08 06; 33(16):1429-1441.
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Tunstead C, Volkova E, Dunbar H, Hawthorne IJ, Bell A, Crowe L, Masterson JC, Dos Santos CC, McNicholas B, Laffey JG, English K. The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation. Mol Ther. 2024 Oct 02; 32(10):3422-3432.
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