 Interleukin-6
"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
| Descriptor ID |
D015850
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| MeSH Number(s) |
D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
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| Concept/Terms |
Interleukin-6- Interleukin-6
- Interleukin 6
- IL6
- B-Cell Stimulatory Factor 2
- B-Cell Stimulatory Factor-2
- Differentiation Factor-2, B-Cell
- Differentiation Factor 2, B Cell
- B-Cell Differentiation Factor-2
- B Cell Differentiation Factor 2
- BSF-2
- Hybridoma Growth Factor
- Growth Factor, Hybridoma
- IFN-beta 2
- Plasmacytoma Growth Factor
- Growth Factor, Plasmacytoma
- Hepatocyte-Stimulating Factor
- Hepatocyte Stimulating Factor
- MGI-2
- Myeloid Differentiation-Inducing Protein
- Differentiation-Inducing Protein, Myeloid
- Myeloid Differentiation Inducing Protein
- B-Cell Differentiation Factor
- B Cell Differentiation Factor
- Differentiation Factor, B-Cell
- Differentiation Factor, B Cell
- IL-6
- Interferon beta-2
- Interferon beta 2
- beta-2, Interferon
- B Cell Stimulatory Factor-2
- B Cell Stimulatory Factor 2
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Below are MeSH descriptors whose meaning is more general than "Interleukin-6".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".
This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 4 | 3 | 7 | | 1997 | 4 | 8 | 12 | | 1998 | 5 | 7 | 12 | | 1999 | 7 | 7 | 14 | | 2000 | 3 | 2 | 5 | | 2001 | 2 | 6 | 8 | | 2002 | 0 | 12 | 12 | | 2003 | 2 | 11 | 13 | | 2004 | 6 | 7 | 13 | | 2005 | 1 | 12 | 13 | | 2006 | 7 | 11 | 18 | | 2007 | 10 | 10 | 20 | | 2008 | 8 | 16 | 24 | | 2009 | 9 | 21 | 30 | | 2010 | 8 | 9 | 17 | | 2011 | 4 | 14 | 18 | | 2012 | 8 | 14 | 22 | | 2013 | 5 | 16 | 21 | | 2014 | 6 | 22 | 28 | | 2015 | 5 | 12 | 17 | | 2016 | 3 | 14 | 17 | | 2017 | 4 | 6 | 10 | | 2018 | 6 | 12 | 18 | | 2019 | 3 | 11 | 14 | | 2020 | 10 | 13 | 23 | | 2021 | 8 | 11 | 19 | | 2022 | 8 | 13 | 21 | | 2023 | 4 | 15 | 19 | | 2024 | 6 | 6 | 12 | | 2025 | 4 | 10 | 14 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-6" by people in Profiles.
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Singh S, Singh AK, Singh AN, Singh SK, Yadav VB, Gangwar M, Sahu M, Kumar D, Nath G. Efficacy of bacteriophage cocktails administered through mucosal and non-mucosal routes for urinary tract infections caused by Enterobacter cloacae: A preclinical study. Microb Pathog. 2025 Dec; 209:108024.
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Scharf G, Davidson CR, Ustiyan V, Falkenberg LG, Adavalli A, Meeker JD, Morgan H, Ostmann AJ, Hudock KM, Brewington JJ, Clancy JP, Kramer EL. TGF-ß induces excessive pulmonary IL-6 secretion in cystic fibrosis via PI3K. Am J Physiol Lung Cell Mol Physiol. 2025 Oct 01; 329(4):L470-L479.
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Khair S, Najarro KM, Walrath TM, Orlicky DJ, McMahan RH, Kovacs EJ. Post-burn Lung Inflammation Is Associated With Induction of Pulmonary Cathelicidin-related Antimicrobial Peptide and S100a8 in Mice. J Burn Care Res. 2025 08 30; 46(4):917-926.
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Grayck MR, Smith BJ, Sosa A, Golden E, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Dobrinskikh E, Rincon M, McCulley DJ, Orlicky DJ, Wright CJ. A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung. Am J Respir Cell Mol Biol. 2025 Aug; 73(2):232-250.
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Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025 Sep; 645(8080):496-506.
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Kowalski RG, Ledreux A, Violette JE, Paustian W, Sillau S, Thompson JA, Neumann RT, Ornelas D, Monte AA, Dylla L, Ginde AA, Farcas AM, Coughlan CM, Jones WJ, Grotta JC, Graner MW. Circulating Interleukin-6 Levels and Timing of Acute Ischemic Stroke Onset. Ann Clin Transl Neurol. 2025 Sep; 12(9):1926-1931.
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Hayashi Y, Hatano M, Kaneko S, Shimbo A, Irabu H, Mori M, Shimizu M. Macrophage activation syndrome associated with neonatal lupus erythematosus. Lupus. 2025 Aug; 34(9):978-981.
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Lundin JI, Peters U, Hu Y, Ammous F, Benjamin EJ, Bis JC, Brody JA, Cushman M, Fuller H, Gignoux C, Guo X, Haessler J, Haiman C, Joehanes R, Kasela S, Kenny E, Lappalainen T, Levy D, Liu C, Liu Y, Loos RJF, Matise T, North KE, Park SL, Ratliff SM, Reiner A, Rich SS, Rotter JI, Smith JA, Sotoodehnia N, Tracy R, Van den Berg D, Ye T, Zhao W, Raffield LM, Kooperberg C. Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease. Atherosclerosis. 2025 Aug; 407:120219.
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Larson EA, Smith LE, Perng W, Switkowski KM, Rifas-Shiman SL, Oken E. The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva. J Nutr. 2025 Jun; 155(6):1999-2005.
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Gong J, Chan KS, Rajesh A, Droho S, Lavine JA. Adrb2 Expression in Ocular-Infiltrating Macrophages Is Necessary for Interleukin-6 Expression and Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):43.
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