 Endothelin-1
"Endothelin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
| Descriptor ID |
D019332
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| MeSH Number(s) |
D12.644.276.400.225 D12.776.467.400.225 D23.529.400.225
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| Concept/Terms |
Proendothelin (1-38)- Proendothelin (1-38)
- Big Endothelin
- Big Endothelin-1
- Big Endothelin 1
- Endothelin-1, Big
- Endothelin, Big
Preproendothelin-1- Preproendothelin-1
- Preproendothelin 1
- Preproendothelin
- Proendothelin-1 Precursor
- Precursor, Proendothelin-1
- Proendothelin 1 Precursor
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Below are MeSH descriptors whose meaning is more general than "Endothelin-1".
Below are MeSH descriptors whose meaning is more specific than "Endothelin-1".
This graph shows the total number of publications written about "Endothelin-1" by people in this website by year, and whether "Endothelin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 5 | 6 | | 1999 | 3 | 1 | 4 | | 2000 | 2 | 4 | 6 | | 2001 | 3 | 0 | 3 | | 2002 | 0 | 2 | 2 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 1 | 4 | | 2007 | 2 | 2 | 4 | | 2008 | 2 | 0 | 2 | | 2009 | 3 | 2 | 5 | | 2010 | 3 | 5 | 8 | | 2011 | 2 | 1 | 3 | | 2012 | 8 | 2 | 10 | | 2013 | 3 | 3 | 6 | | 2014 | 3 | 0 | 3 | | 2015 | 4 | 2 | 6 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 2 | 4 | | 2019 | 1 | 2 | 3 | | 2020 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 1 | 2 | | 2025 | 1 | 4 | 5 | | 2026 | 0 | 2 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Endothelin-1" by people in Profiles.
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Ruzzene ST, Garcia VP, Berry AR, Stone MF, Wegerson KN, Ostrander EI, Fandl HK, Greiner JJ, Park AJ, Stauffer BL, DeSouza CA. Obesity-related circulating endothelial extracellular vesicles negatively affect cerebral microvascular cell function. Am J Physiol Endocrinol Metab. 2026 Aug 01; 331(2):E165-E173.
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Berry AR, Ruzzene ST, Garcia VP, Wegerson KN, Cardenas HL, Ostrander EI, Fandl HK, Izaias JE, Greiner JJ, Stauffer BL, DeSouza CA. Age-related circulating endothelial extracellular vesicles promote cerebral microvascular cell dysfunction. Am J Physiol Heart Circ Physiol. 2026 Aug 01; 331(2):H537-H546.
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Berry AR, Ruzzene ST, Ostrander EI, Wegerson KN, Orozco-Fersiva NC, Stone MF, Valenti WB, Izaias JE, Holzer JP, Greiner JJ, Garcia VP, DeSouza CA. The non-nutritive sweetener erythritol adversely affects brain microvascular endothelial cell function. J Appl Physiol (1985). 2025 Jun 01; 138(6):1571-1577.
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Nasci VL, Bopassa JC, Mironova E, Rhoads M, Singh R, Buehler DP, Pollock DM, Pochynyuk OM, Stockand JD, Gohar EY. Renal G protein-coupled estrogen receptor 1 regulates the epithelial sodium channel promoting natriuresis to a greater extent in females. Am J Physiol Renal Physiol. 2025 07 01; 329(1):F1-F10.
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Kanai SM, Garcia CR, Augustus MR, Sharafeldeen SA, Brooks EP, Sucharov J, Lencer ES, Nichols JT, Clouthier DE. The Gq/11 family of Ga subunits is necessary and sufficient for lower jaw development. Development. 2025 Apr 15; 152(8).
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Garcia VP, Fandl HK, Wegerson KN, Berry AR, Ruzzene ST, Greiner JJ, Stockelman KA, Dow CA, Park AJ, Stauffer BL, DeSouza CA. Elevated circulating endothelial cell-derived microvesicles: a biomarker of endothelial vasomotor dysfunction in adults with obesity. J Appl Physiol (1985). 2025 05 01; 138(5):1143-1149.
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Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Kohrt WM, Wenner MM, Moreau KL. Endothelial dysfunction in middle-aged and older men with low testosterone is associated with elevated circulating endothelin-1. Am J Physiol Regul Integr Comp Physiol. 2025 03 01; 328(3):R253-R261.
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Kanai SM, Clouthier DE. Endothelin signaling in development. Development. 2023 12 15; 150(24).
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Wenner MM, Welti LM, Dow CA, Greiner JJ, Stauffer BL, DeSouza CA. Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H732-H738.
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Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, DiMaria MV, Davidson JA. Increased Circulating Endothelin 1 Is Associated With Postoperative Hypoxemia in Infants With Single-Ventricle Heart Disease Undergoing Superior Cavopulmonary Anastomosis. J Am Heart Assoc. 2022 03 15; 11(6):e024007.
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