 Endothelin-1
"Endothelin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
| Descriptor ID |
D019332
|
| MeSH Number(s) |
D12.644.276.400.225 D12.776.467.400.225 D23.529.400.225
|
| Concept/Terms |
Proendothelin (1-38)- Proendothelin (1-38)
- Big Endothelin
- Big Endothelin-1
- Big Endothelin 1
- Endothelin-1, Big
- Endothelin, Big
Preproendothelin-1- Preproendothelin-1
- Preproendothelin 1
- Preproendothelin
- Proendothelin-1 Precursor
- Precursor, Proendothelin-1
- Proendothelin 1 Precursor
|
Below are MeSH descriptors whose meaning is more general than "Endothelin-1".
Below are MeSH descriptors whose meaning is more specific than "Endothelin-1".
This graph shows the total number of publications written about "Endothelin-1" by people in this website by year, and whether "Endothelin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 5 | 6 | | 1999 | 3 | 1 | 4 | | 2000 | 1 | 4 | 5 | | 2001 | 2 | 0 | 2 | | 2002 | 0 | 2 | 2 | | 2004 | 3 | 0 | 3 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 1 | 4 | | 2007 | 2 | 2 | 4 | | 2008 | 2 | 0 | 2 | | 2009 | 3 | 2 | 5 | | 2010 | 3 | 5 | 8 | | 2011 | 2 | 1 | 3 | | 2012 | 8 | 2 | 10 | | 2013 | 3 | 2 | 5 | | 2014 | 3 | 0 | 3 | | 2015 | 4 | 2 | 6 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 1 | 3 | | 2019 | 1 | 2 | 3 | | 2020 | 2 | 2 | 4 | | 2022 | 1 | 1 | 2 | | 2023 | 1 | 1 | 2 | | 2025 | 1 | 2 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Endothelin-1" by people in Profiles.
-
Kanai SM, Garcia CR, Augustus MR, Sharafeldeen SA, Brooks EP, Sucharov J, Lencer ES, Nichols JT, Clouthier DE. The Gq/11 family of Ga subunits is necessary and sufficient for lower jaw development. Development. 2025 Apr 15; 152(8).
-
Garcia VP, Fandl HK, Wegerson KN, Berry AR, Ruzzene ST, Greiner JJ, Stockelman KA, Dow CA, Park AJ, Stauffer BL, DeSouza CA. Elevated circulating endothelial cell-derived microvesicles: a biomarker of endothelial vasomotor dysfunction in adults with obesity. J Appl Physiol (1985). 2025 May 01; 138(5):1143-1149.
-
Babcock MC, DuBose LE, Hildreth KL, Stauffer BL, Kohrt WM, Wenner MM, Moreau KL. Endothelial dysfunction in middle-aged and older men with low testosterone is associated with elevated circulating endothelin-1. Am J Physiol Regul Integr Comp Physiol. 2025 Mar 01; 328(3):R253-R261.
-
Kanai SM, Clouthier DE. Endothelin signaling in development. Development. 2023 Dec 15; 150(24).
-
Wenner MM, Welti LM, Dow CA, Greiner JJ, Stauffer BL, DeSouza CA. Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H732-H738.
-
Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, DiMaria MV, Davidson JA. Increased Circulating Endothelin 1 Is Associated With Postoperative Hypoxemia in Infants With Single-Ventricle Heart Disease Undergoing Superior Cavopulmonary Anastomosis. J Am Heart Assoc. 2022 03 15; 11(6):e024007.
-
Gohar EY, De Miguel C, Obi IE, Daugherty EM, Hyndman KA, Becker BK, Jin C, Sedaka R, Johnston JG, Liu P, Speed JS, Mitchell T, Kriegel AJ, Pollock JS, Pollock DM. Acclimation to a High-Salt Diet Is Sex Dependent. J Am Heart Assoc. 2022 03; 11(5):e020450.
-
Sedaka R, Hyndman KA, Mironova E, Stockand JD, Pollock JS. High salt intake induces collecting duct HDAC1-dependent NO signaling. Am J Physiol Renal Physiol. 2021 03 01; 320(3):F297-F307.
-
Gohar EY, Daugherty EM, Aceves JO, Sedaka R, Obi IE, Allan JM, Soliman RH, Jin C, De Miguel C, Lindsey SH, Pollock JS, Pollock DM. Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor. J Am Heart Assoc. 2020 05 18; 9(10):e015110.
-
Brewster LM, Garcia VP, Levy MV, Stockelman KA, Goulding A, DeSouza NM, Greiner JJ, Hijmans JG, DeSouza CA. Endothelin-1-induced endothelial microvesicles impair endothelial cell function. J Appl Physiol (1985). 2020 06 01; 128(6):1497-1505.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|