 Endothelin-1
"Endothelin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
| Descriptor ID |
D019332
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| MeSH Number(s) |
D12.644.276.400.225 D12.776.467.400.225 D23.529.400.225
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| Concept/Terms |
Proendothelin (1-38)- Proendothelin (1-38)
- Big Endothelin
- Big Endothelin-1
- Big Endothelin 1
- Endothelin-1, Big
- Endothelin, Big
Preproendothelin-1- Preproendothelin-1
- Preproendothelin 1
- Preproendothelin
- Proendothelin-1 Precursor
- Precursor, Proendothelin-1
- Proendothelin 1 Precursor
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Below are MeSH descriptors whose meaning is more general than "Endothelin-1".
Below are MeSH descriptors whose meaning is more specific than "Endothelin-1".
This graph shows the total number of publications written about "Endothelin-1" by people in this website by year, and whether "Endothelin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 | | 1996 | 2 | 0 | 2 | | 1997 | 0 | 1 | 1 | | 1998 | 1 | 5 | 6 | | 1999 | 3 | 1 | 4 | | 2000 | 2 | 4 | 6 | | 2001 | 2 | 0 | 2 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 1 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2006 | 3 | 1 | 4 | | 2007 | 2 | 2 | 4 | | 2008 | 2 | 0 | 2 | | 2009 | 3 | 2 | 5 | | 2010 | 2 | 5 | 7 | | 2011 | 2 | 1 | 3 | | 2012 | 8 | 1 | 9 | | 2013 | 3 | 3 | 6 | | 2014 | 3 | 0 | 3 | | 2015 | 4 | 2 | 6 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 1 | 3 | | 2019 | 1 | 1 | 2 | | 2020 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 | | 2023 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Endothelin-1" by people in Profiles.
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Kanai SM, Clouthier DE. Endothelin signaling in development. Development. 2023 Dec 15; 150(24).
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Wenner MM, Welti LM, Dow CA, Greiner JJ, Stauffer BL, DeSouza CA. Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H732-H738.
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Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, DiMaria MV, Davidson JA. Increased Circulating Endothelin 1 Is Associated With Postoperative Hypoxemia in Infants With Single-Ventricle Heart Disease Undergoing Superior Cavopulmonary Anastomosis. J Am Heart Assoc. 2022 03 15; 11(6):e024007.
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Brewster LM, Garcia VP, Levy MV, Stockelman KA, Goulding A, DeSouza NM, Greiner JJ, Hijmans JG, DeSouza CA. Endothelin-1-induced endothelial microvesicles impair endothelial cell function. J Appl Physiol (1985). 2020 06 01; 128(6):1497-1505.
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Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 03; 34(3):4283-4292.
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Thosar SS, Berman AM, Herzig MX, McHill AW, Bowles NP, Swanson CM, Clemons NA, Butler MP, Clemons AA, Emens JS, Shea SA. Circadian Rhythm of Vascular Function in Midlife Adults. Arterioscler Thromb Vasc Biol. 2019 06; 39(6):1203-1211.
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Frank BS, Urban TT, Lewis K, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta. Congenit Heart Dis. 2019 May; 14(3):446-453.
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Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC. Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):154-163.
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Dow CA, Stauffer BL, Brunjes DL, Greiner JJ, DeSouza CA. Regular aerobic exercise reduces endothelin-1-mediated vasoconstrictor tone in overweight and obese adults. Exp Physiol. 2017 09 01; 102(9):1133-1142.
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Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 06 01; 144(11):2021-2031.
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