Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Irwin

Concepts (285)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Anemia, Sickle Cell
16
2026
312
6.470
Why?
Hemoglobins
11
2026
381
3.230
Why?
Hemopexin
5
2025
38
2.570
Why?
Hypertension, Pulmonary
12
2026
1946
2.380
Why?
beta-Thalassemia
2
2025
40
1.630
Why?
Hemolysis
8
2026
242
1.620
Why?
Haptoglobins
5
2026
66
1.620
Why?
Hypoxia
11
2026
1193
1.170
Why?
Altitude Sickness
4
2016
141
1.140
Why?
Exercise Tolerance
4
2025
282
1.090
Why?
Altitude
4
2022
473
1.070
Why?
Iron
4
2025
356
1.050
Why?
Lung
7
2025
4084
1.040
Why?
Heme
3
2025
89
1.030
Why?
Pulmonary Edema
3
2019
105
1.030
Why?
Muscle, Skeletal
4
2025
1784
0.800
Why?
Animals
40
2026
37800
0.760
Why?
Spleen
1
2025
507
0.750
Why?
Oxygen
5
2024
978
0.720
Why?
Pulmonary Ventilation
1
2022
82
0.720
Why?
Rats
17
2024
5553
0.690
Why?
Capillary Permeability
4
2016
132
0.650
Why?
Vascular Remodeling
3
2022
203
0.650
Why?
Disease Models, Animal
14
2026
4525
0.640
Why?
Beta vulgaris
1
2020
14
0.640
Why?
Pulmonary Artery
6
2022
1124
0.630
Why?
Proteome
1
2025
512
0.620
Why?
Rats, Sprague-Dawley
12
2024
2512
0.620
Why?
Emulsions
1
2019
57
0.610
Why?
Atrial Natriuretic Factor
3
2005
55
0.600
Why?
Endothelium, Vascular
3
2018
948
0.600
Why?
Vasodilator Agents
2
2013
329
0.590
Why?
Blood Substitutes
2
2009
27
0.570
Why?
Reactive Oxygen Species
2
2013
601
0.550
Why?
Fluorocarbons
1
2019
119
0.550
Why?
Mice
19
2026
18218
0.540
Why?
Oxygen Consumption
3
2024
715
0.520
Why?
Physical Exertion
1
2018
205
0.520
Why?
Carbonic Anhydrase Inhibitors
1
2016
14
0.500
Why?
Cerebral Veins
1
2016
16
0.500
Why?
Toll-Like Receptor 9
1
2017
37
0.500
Why?
Angiogenesis Inducing Agents
1
2016
25
0.490
Why?
Microvessels
1
2018
98
0.490
Why?
Brain Edema
1
2016
62
0.490
Why?
Water
1
2019
465
0.480
Why?
Cerebral Arteries
1
2016
59
0.480
Why?
Liver
1
2025
1884
0.470
Why?
Drug Delivery Systems
1
2019
379
0.470
Why?
NF-E2-Related Factor 2
2
2013
95
0.460
Why?
Macrophages
2
2023
1496
0.460
Why?
Muscle Contraction
1
2018
429
0.440
Why?
Angiogenesis Inhibitors
1
2016
236
0.440
Why?
Exercise
2
2024
2183
0.420
Why?
Transcriptional Activation
2
2013
372
0.400
Why?
Endothelial Cells
2
2013
862
0.400
Why?
Vascular Diseases
2
2015
251
0.390
Why?
Myeloid Differentiation Factor 88
1
2013
117
0.370
Why?
Mice, Inbred C57BL
6
2025
5954
0.370
Why?
Inflammation
4
2026
2862
0.360
Why?
Hypoxia-Inducible Factor 1, alpha Subunit
3
2014
294
0.360
Why?
Glutaral
1
2009
13
0.300
Why?
Male
21
2026
72263
0.290
Why?
Phosphodiesterase 5 Inhibitors
1
2009
35
0.290
Why?
Lung Diseases
2
2015
780
0.290
Why?
Phosphodiesterase Inhibitors
1
2009
72
0.290
Why?
Proteomics
3
2025
1182
0.290
Why?
Phenylpropionates
2
2019
27
0.280
Why?
Oxidative Stress
4
2025
1331
0.280
Why?
Sulfones
1
2009
126
0.280
Why?
Pyridazines
2
2019
57
0.280
Why?
Vascular Resistance
3
2016
367
0.270
Why?
Endothelins
2
2018
61
0.270
Why?
Disease Progression
3
2023
2844
0.260
Why?
Polymers
2
2009
484
0.260
Why?
Nitric Oxide
3
2018
894
0.250
Why?
Humans
26
2026
144298
0.240
Why?
Lipid Peroxidation
3
2018
160
0.240
Why?
Piperazines
1
2009
378
0.240
Why?
Respiration
2
2022
204
0.240
Why?
Vascular Endothelial Growth Factor A
1
2009
549
0.240
Why?
Extracorporeal Circulation
1
2026
14
0.240
Why?
Physical Conditioning, Animal
2
2025
241
0.230
Why?
Cell Nucleus
1
2009
591
0.230
Why?
Transferrin
1
2025
50
0.230
Why?
Blood Pressure
5
2018
1763
0.220
Why?
Muscle, Smooth, Vascular
4
2017
440
0.220
Why?
Capillary Leak Syndrome
1
2005
12
0.220
Why?
Cardiac Output
3
2012
178
0.220
Why?
Cation Transport Proteins
1
2026
118
0.220
Why?
Lignans
1
2024
12
0.220
Why?
Glucosephosphate Dehydrogenase Deficiency
1
2025
34
0.210
Why?
Neprilysin
1
2005
47
0.210
Why?
Heme Oxygenase-1
1
2025
74
0.210
Why?
Biphenyl Compounds
1
2024
66
0.210
Why?
Glucosephosphate Dehydrogenase
1
2025
70
0.210
Why?
NAD
1
2024
82
0.210
Why?
Sirtuin 3
1
2024
58
0.200
Why?
Aerosols
1
2025
187
0.200
Why?
Intercellular Adhesion Molecule-1
2
2015
129
0.200
Why?
Endothelin-1
1
2005
181
0.190
Why?
Ventricular Function, Right
1
2025
296
0.190
Why?
Pulmonary Circulation
2
2019
429
0.190
Why?
Glycolysis
1
2025
340
0.190
Why?
Oxidation-Reduction
3
2018
1073
0.190
Why?
Antibodies
2
2021
396
0.180
Why?
Oxyhemoglobins
1
2021
28
0.170
Why?
Magnetics
1
2021
47
0.170
Why?
Scleroderma, Systemic
1
2022
123
0.170
Why?
Leukocytes, Mononuclear
1
2023
572
0.160
Why?
Muscle Proteins
1
2022
240
0.160
Why?
Monocytes
1
2023
534
0.160
Why?
Metabolic Diseases
1
2021
114
0.160
Why?
CD40 Antigens
1
2021
89
0.160
Why?
Extracellular Vesicles
1
2023
170
0.160
Why?
RNA, Long Noncoding
1
2022
172
0.160
Why?
Up-Regulation
2
2013
847
0.160
Why?
Alternative Splicing
1
2022
245
0.160
Why?
Endotoxins
1
2001
217
0.150
Why?
Histone Deacetylases
2
2012
207
0.150
Why?
Nitrates
1
2020
100
0.150
Why?
Phenotype
2
2026
3139
0.150
Why?
Receptors, G-Protein-Coupled
1
2021
231
0.150
Why?
Gadolinium
1
2019
84
0.150
Why?
Drug Evaluation, Preclinical
1
2019
193
0.140
Why?
Enoyl-CoA Hydratase
1
2018
12
0.140
Why?
Cell Line
2
2015
2821
0.140
Why?
Blood Gas Analysis
2
2008
81
0.140
Why?
Carrier Proteins
1
2022
733
0.140
Why?
Metabolome
1
2021
383
0.140
Why?
Double-Blind Method
2
2020
2032
0.140
Why?
Aminophylline
1
2017
12
0.130
Why?
Liver Diseases
1
2021
304
0.130
Why?
Antioxidants
2
2013
542
0.130
Why?
Lipids
2
2023
702
0.130
Why?
Cells, Cultured
6
2014
4102
0.130
Why?
Lipoproteins
1
2018
164
0.130
Why?
Anemia, Hemolytic
1
2017
16
0.130
Why?
Deferoxamine
1
2016
27
0.130
Why?
Cell Proliferation
2
2017
2485
0.130
Why?
Acetazolamide
1
2016
26
0.130
Why?
Acclimatization
1
2018
172
0.120
Why?
Niacinamide
1
2016
86
0.120
Why?
Mice, Knockout
3
2022
3106
0.120
Why?
NF-kappa B
2
2013
656
0.120
Why?
Dietary Supplements
1
2020
575
0.120
Why?
Myocytes, Cardiac
3
2022
538
0.120
Why?
Oligonucleotides
1
2016
151
0.120
Why?
Methemoglobin
2
2021
24
0.110
Why?
Cardiomyopathy, Dilated
1
2018
355
0.110
Why?
Antihypertensive Agents
1
2019
512
0.110
Why?
Signal Transduction
5
2017
5182
0.110
Why?
Vasoconstriction
1
2016
216
0.110
Why?
Hypertrophy, Right Ventricular
1
2015
149
0.100
Why?
Cattle
2
2008
971
0.100
Why?
Chloride Channels
1
2014
33
0.100
Why?
RNA, Small Interfering
3
2012
629
0.100
Why?
Catalase
1
2013
130
0.100
Why?
Cell Membrane Permeability
1
2013
85
0.100
Why?
Genomics
1
2018
828
0.100
Why?
Histone Deacetylase Inhibitors
2
2012
218
0.100
Why?
Permeability
1
2013
168
0.100
Why?
Indoles
1
2016
500
0.090
Why?
Interleukin-6
1
2017
770
0.090
Why?
Ventricular Remodeling
2
2012
275
0.090
Why?
Cyclic N-Oxides
1
2012
32
0.090
Why?
Infusion Pumps
1
2012
33
0.090
Why?
Spin Labels
1
2012
59
0.090
Why?
Macrophages, Alveolar
1
2015
368
0.090
Why?
Heart Failure
2
2022
2323
0.090
Why?
Mitochondrial Proteins
1
2014
262
0.090
Why?
Gene Expression Regulation, Enzymologic
1
2012
268
0.090
Why?
Superoxide Dismutase
1
2013
300
0.090
Why?
Toll-Like Receptor 4
1
2013
276
0.090
Why?
Cerebellum
1
2013
222
0.080
Why?
Cardiovascular Diseases
2
2021
2170
0.080
Why?
Hydrogen Peroxide
1
2012
332
0.080
Why?
Microcirculation
2
2014
141
0.080
Why?
Blotting, Western
1
2012
1160
0.080
Why?
Sildenafil Citrate
1
2009
60
0.070
Why?
Pneumonia
1
2015
627
0.070
Why?
Active Transport, Cell Nucleus
1
2009
120
0.070
Why?
Hypoxia, Brain
1
2008
9
0.070
Why?
NG-Nitroarginine Methyl Ester
1
2008
48
0.070
Why?
Purines
1
2009
187
0.070
Why?
Mice, Transgenic
2
2025
2177
0.070
Why?
Nitric Oxide Synthase
1
2008
234
0.070
Why?
Epinephrine
1
2008
154
0.060
Why?
Norepinephrine
1
2008
195
0.060
Why?
Hemodynamics
1
2012
1113
0.060
Why?
Female
7
2022
78137
0.060
Why?
Dogs
1
2008
435
0.060
Why?
Mesocricetus
1
2026
46
0.060
Why?
Protein Isoforms
2
2022
393
0.060
Why?
Myocardium
1
2011
927
0.060
Why?
Cricetinae
1
2026
296
0.060
Why?
RNA, Messenger
1
2013
2808
0.060
Why?
Stress Fibers
1
2004
18
0.060
Why?
Stroke Volume
1
2008
650
0.050
Why?
Enzyme Inhibitors
1
2008
819
0.050
Why?
Allyl Compounds
1
2024
26
0.050
Why?
Tissue Distribution
1
2025
333
0.050
Why?
Treatment Outcome
1
2019
11713
0.050
Why?
Sirtuins
1
2024
48
0.050
Why?
Kidney
1
2012
1493
0.050
Why?
Heart Rate
1
2008
849
0.050
Why?
Phenols
1
2024
107
0.050
Why?
p38 Mitogen-Activated Protein Kinases
1
2004
264
0.050
Why?
Actins
1
2004
421
0.050
Why?
Hypertension
1
2011
1259
0.050
Why?
Catecholamines
1
2022
87
0.050
Why?
RNA Splicing Factors
1
2022
66
0.040
Why?
Thrombin
1
2023
165
0.040
Why?
In Situ Hybridization, Fluorescence
1
2022
322
0.040
Why?
Lung Neoplasms
1
2014
2643
0.040
Why?
Lipopolysaccharides
1
2004
854
0.040
Why?
Etanercept
1
2021
60
0.040
Why?
Salmonella enteritidis
1
2001
17
0.040
Why?
Case-Control Studies
2
2018
3595
0.040
Why?
Tumor Necrosis Factor-alpha
1
2004
1206
0.040
Why?
Protein Binding
1
2026
2241
0.040
Why?
Ligands
1
2021
661
0.040
Why?
Arrhythmias, Cardiac
1
2022
355
0.040
Why?
Intracellular Signaling Peptides and Proteins
1
2022
454
0.040
Why?
Metabolomics
1
2025
722
0.040
Why?
Fatty Acids
1
2022
447
0.040
Why?
Erythrocytes
1
2025
750
0.040
Why?
Heart
1
2022
625
0.030
Why?
Guinea Pigs
1
2018
159
0.030
Why?
Linkage Disequilibrium
1
2018
249
0.030
Why?
Tissue Donors
1
2021
412
0.030
Why?
Ventricular Dysfunction, Right
1
2021
248
0.030
Why?
Inflammation Mediators
1
2021
503
0.030
Why?
Cytochrome P-450 Enzyme System
1
2018
161
0.030
Why?
Cytoskeleton
1
2018
195
0.030
Why?
Genetics, Population
1
2018
215
0.030
Why?
Proteins
1
2023
1011
0.030
Why?
Heart Ventricles
2
2012
750
0.030
Why?
Sequence Analysis, RNA
1
2018
441
0.030
Why?
Mice, Inbred Strains
2
2014
396
0.030
Why?
Gene Regulatory Networks
1
2018
318
0.030
Why?
Adenosine
1
2017
255
0.030
Why?
Sarcoma, Experimental
1
2014
6
0.030
Why?
Rats, Nude
1
2014
25
0.030
Why?
Intravital Microscopy
1
2014
24
0.030
Why?
Drug Therapy, Combination
1
2017
1044
0.030
Why?
Heterografts
1
2014
143
0.030
Why?
Coronary Vessels
1
2016
246
0.030
Why?
Models, Biological
1
2021
1807
0.030
Why?
Genotype
1
2018
1843
0.020
Why?
Transcription Factor RelA
1
2014
85
0.020
Why?
Swine
1
2016
817
0.020
Why?
Familial Primary Pulmonary Hypertension
1
2014
196
0.020
Why?
Blood Flow Velocity
1
2014
419
0.020
Why?
Cytokines
1
2021
2043
0.020
Why?
Neovascularization, Pathologic
1
2014
283
0.020
Why?
Chemistry, Physical
1
2012
39
0.020
Why?
Fructans
1
1992
1
0.020
Why?
Genes, Immunoglobulin
1
1992
29
0.020
Why?
MicroRNAs
1
2018
689
0.020
Why?
Immunoglobulin Variable Region
1
1992
80
0.020
Why?
Immunoglobulin Light Chains
1
1992
51
0.020
Why?
Immunoglobulin Heavy Chains
1
1992
85
0.020
Why?
Adult
3
2023
40408
0.020
Why?
Mitochondria
1
2018
981
0.020
Why?
Gene Expression Profiling
1
2018
1762
0.020
Why?
Histone Deacetylase 6
1
2011
17
0.020
Why?
Polymorphism, Single Nucleotide
1
2018
2134
0.020
Why?
Young Adult
2
2018
14092
0.020
Why?
Benzamides
1
2012
224
0.020
Why?
Adenoviridae
1
2011
199
0.020
Why?
Regional Blood Flow
1
2012
513
0.020
Why?
RNA Interference
1
2011
472
0.020
Why?
Pyrimidines
1
2012
518
0.020
Why?
Polymerase Chain Reaction
1
2011
1046
0.020
Why?
Cohort Studies
1
2018
5948
0.020
Why?
Pyridines
1
2012
601
0.020
Why?
Cell Line, Tumor
1
2014
3520
0.020
Why?
Middle Aged
2
2018
35892
0.010
Why?
Antibodies, Monoclonal
1
1992
1501
0.010
Why?
Child
1
2023
22562
0.010
Why?
Breast Neoplasms
1
2014
2363
0.010
Why?
Adolescent
1
2017
22370
0.010
Why?
Antibody Diversity
1
1992
16
0.010
Why?
Immunoglobulin Isotypes
1
1992
35
0.010
Why?
Antibody Specificity
1
1992
178
0.010
Why?
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