Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Irwin

Concepts (285)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Anemia, Sickle Cell
16
2026
312
6.500
Why?
Hemoglobins
11
2026
384
3.240
Why?
Hemopexin
5
2025
38
2.580
Why?
Hypertension, Pulmonary
12
2026
1980
2.370
Why?
beta-Thalassemia
2
2025
40
1.630
Why?
Hemolysis
8
2026
243
1.630
Why?
Haptoglobins
5
2026
66
1.630
Why?
Hypoxia
11
2026
1199
1.170
Why?
Altitude Sickness
4
2016
141
1.150
Why?
Exercise Tolerance
4
2025
283
1.100
Why?
Altitude
4
2022
473
1.080
Why?
Iron
4
2025
359
1.050
Why?
Heme
3
2025
89
1.040
Why?
Lung
7
2025
4109
1.040
Why?
Pulmonary Edema
3
2019
106
1.030
Why?
Muscle, Skeletal
4
2025
1795
0.810
Why?
Animals
40
2026
38058
0.760
Why?
Spleen
1
2025
508
0.750
Why?
Pulmonary Ventilation
1
2022
83
0.720
Why?
Oxygen
5
2024
995
0.720
Why?
Rats
17
2024
5597
0.690
Why?
Capillary Permeability
4
2016
134
0.660
Why?
Vascular Remodeling
3
2022
205
0.650
Why?
Beta vulgaris
1
2020
14
0.640
Why?
Disease Models, Animal
14
2026
4557
0.640
Why?
Pulmonary Artery
6
2022
1134
0.630
Why?
Proteome
1
2025
518
0.620
Why?
Rats, Sprague-Dawley
12
2024
2527
0.620
Why?
Emulsions
1
2019
57
0.610
Why?
Atrial Natriuretic Factor
3
2005
57
0.610
Why?
Endothelium, Vascular
3
2018
965
0.600
Why?
Vasodilator Agents
2
2013
331
0.600
Why?
Blood Substitutes
2
2009
28
0.570
Why?
Reactive Oxygen Species
2
2013
621
0.550
Why?
Mice
19
2026
18339
0.540
Why?
Fluorocarbons
1
2019
143
0.530
Why?
Physical Exertion
1
2018
207
0.520
Why?
Oxygen Consumption
3
2024
724
0.520
Why?
Carbonic Anhydrase Inhibitors
1
2016
14
0.510
Why?
Cerebral Veins
1
2016
16
0.500
Why?
Toll-Like Receptor 9
1
2017
37
0.500
Why?
Angiogenesis Inducing Agents
1
2016
26
0.500
Why?
Microvessels
1
2018
99
0.500
Why?
Brain Edema
1
2016
62
0.490
Why?
Cerebral Arteries
1
2016
58
0.480
Why?
Water
1
2019
469
0.480
Why?
Liver
1
2025
1887
0.480
Why?
Drug Delivery Systems
1
2019
380
0.480
Why?
NF-E2-Related Factor 2
2
2013
95
0.460
Why?
Macrophages
2
2023
1511
0.460
Why?
Muscle Contraction
1
2018
429
0.440
Why?
Angiogenesis Inhibitors
1
2016
237
0.440
Why?
Exercise
2
2024
2201
0.420
Why?
Transcriptional Activation
2
2013
383
0.400
Why?
Endothelial Cells
2
2013
869
0.400
Why?
Vascular Diseases
2
2015
251
0.390
Why?
Myeloid Differentiation Factor 88
1
2013
114
0.380
Why?
Mice, Inbred C57BL
6
2025
5992
0.370
Why?
Inflammation
4
2026
2878
0.370
Why?
Hypoxia-Inducible Factor 1, alpha Subunit
3
2014
297
0.360
Why?
Glutaral
1
2009
13
0.300
Why?
Phosphodiesterase 5 Inhibitors
1
2009
35
0.300
Why?
Male
21
2026
72315
0.300
Why?
Lung Diseases
2
2015
787
0.290
Why?
Phosphodiesterase Inhibitors
1
2009
73
0.290
Why?
Proteomics
3
2025
1195
0.290
Why?
Phenylpropionates
2
2019
27
0.290
Why?
Oxidative Stress
4
2025
1339
0.280
Why?
Sulfones
1
2009
127
0.280
Why?
Pyridazines
2
2019
57
0.280
Why?
Vascular Resistance
3
2016
367
0.270
Why?
Endothelins
2
2018
63
0.270
Why?
Disease Progression
3
2023
2847
0.260
Why?
Polymers
2
2009
499
0.260
Why?
Nitric Oxide
3
2018
897
0.250
Why?
Lipid Peroxidation
3
2018
160
0.250
Why?
Humans
26
2026
144759
0.240
Why?
Piperazines
1
2009
381
0.240
Why?
Respiration
2
2022
206
0.240
Why?
Extracorporeal Circulation
1
2026
15
0.240
Why?
Vascular Endothelial Growth Factor A
1
2009
557
0.240
Why?
Physical Conditioning, Animal
2
2025
243
0.230
Why?
Cell Nucleus
1
2009
618
0.230
Why?
Transferrin
1
2025
50
0.230
Why?
Blood Pressure
5
2018
1769
0.230
Why?
Muscle, Smooth, Vascular
4
2017
452
0.220
Why?
Capillary Leak Syndrome
1
2005
12
0.220
Why?
Cation Transport Proteins
1
2026
118
0.220
Why?
Cardiac Output
3
2012
179
0.220
Why?
Lignans
1
2024
12
0.220
Why?
Glucosephosphate Dehydrogenase Deficiency
1
2025
34
0.220
Why?
Neprilysin
1
2005
47
0.210
Why?
Heme Oxygenase-1
1
2025
74
0.210
Why?
Biphenyl Compounds
1
2024
68
0.210
Why?
Glucosephosphate Dehydrogenase
1
2025
69
0.210
Why?
NAD
1
2024
81
0.210
Why?
Sirtuin 3
1
2024
60
0.200
Why?
Aerosols
1
2025
186
0.200
Why?
Intercellular Adhesion Molecule-1
2
2015
138
0.200
Why?
Endothelin-1
1
2005
184
0.190
Why?
Ventricular Function, Right
1
2025
297
0.190
Why?
Pulmonary Circulation
2
2019
430
0.190
Why?
Glycolysis
1
2025
339
0.190
Why?
Oxidation-Reduction
3
2018
1087
0.190
Why?
Antibodies
2
2021
401
0.180
Why?
Oxyhemoglobins
1
2021
28
0.180
Why?
Magnetics
1
2021
48
0.170
Why?
Scleroderma, Systemic
1
2022
123
0.170
Why?
Leukocytes, Mononuclear
1
2023
573
0.160
Why?
Muscle Proteins
1
2022
244
0.160
Why?
Monocytes
1
2023
538
0.160
Why?
Metabolic Diseases
1
2021
114
0.160
Why?
CD40 Antigens
1
2021
90
0.160
Why?
Extracellular Vesicles
1
2023
171
0.160
Why?
Up-Regulation
2
2013
851
0.160
Why?
Alternative Splicing
1
2022
247
0.160
Why?
RNA, Long Noncoding
1
2022
177
0.160
Why?
Histone Deacetylases
2
2012
210
0.150
Why?
Endotoxins
1
2001
221
0.150
Why?
Nitrates
1
2020
100
0.150
Why?
Phenotype
2
2026
3162
0.150
Why?
Receptors, G-Protein-Coupled
1
2021
233
0.150
Why?
Gadolinium
1
2019
84
0.150
Why?
Drug Evaluation, Preclinical
1
2019
194
0.150
Why?
Enoyl-CoA Hydratase
1
2018
12
0.140
Why?
Cell Line
2
2015
2882
0.140
Why?
Carrier Proteins
1
2022
737
0.140
Why?
Blood Gas Analysis
2
2008
83
0.140
Why?
Metabolome
1
2021
384
0.140
Why?
Double-Blind Method
2
2020
2029
0.140
Why?
Aminophylline
1
2017
12
0.130
Why?
Liver Diseases
1
2021
304
0.130
Why?
Antioxidants
2
2013
549
0.130
Why?
Lipids
2
2023
710
0.130
Why?
Cells, Cultured
6
2014
4154
0.130
Why?
Anemia, Hemolytic
1
2017
16
0.130
Why?
Lipoproteins
1
2018
169
0.130
Why?
Deferoxamine
1
2016
25
0.130
Why?
Cell Proliferation
2
2017
2496
0.130
Why?
Acetazolamide
1
2016
26
0.130
Why?
Acclimatization
1
2018
172
0.120
Why?
Niacinamide
1
2016
86
0.120
Why?
Mice, Knockout
3
2022
3121
0.120
Why?
Dietary Supplements
1
2020
576
0.120
Why?
NF-kappa B
2
2013
661
0.120
Why?
Oligonucleotides
1
2016
151
0.120
Why?
Myocytes, Cardiac
3
2022
556
0.120
Why?
Antihypertensive Agents
1
2019
510
0.110
Why?
Methemoglobin
2
2021
24
0.110
Why?
Cardiomyopathy, Dilated
1
2018
359
0.110
Why?
Vasoconstriction
1
2016
217
0.110
Why?
Signal Transduction
5
2017
5226
0.110
Why?
Hypertrophy, Right Ventricular
1
2015
150
0.110
Why?
Chloride Channels
1
2014
34
0.100
Why?
Cattle
2
2008
1000
0.100
Why?
RNA, Small Interfering
3
2012
635
0.100
Why?
Catalase
1
2013
130
0.100
Why?
Cell Membrane Permeability
1
2013
85
0.100
Why?
Genomics
1
2018
834
0.100
Why?
Histone Deacetylase Inhibitors
2
2012
220
0.100
Why?
Permeability
1
2013
168
0.100
Why?
Indoles
1
2016
501
0.090
Why?
Ventricular Remodeling
2
2012
276
0.090
Why?
Interleukin-6
1
2017
780
0.090
Why?
Cyclic N-Oxides
1
2012
33
0.090
Why?
Infusion Pumps
1
2012
32
0.090
Why?
Spin Labels
1
2012
59
0.090
Why?
Macrophages, Alveolar
1
2015
368
0.090
Why?
Mitochondrial Proteins
1
2014
262
0.090
Why?
Heart Failure
2
2022
2323
0.090
Why?
Gene Expression Regulation, Enzymologic
1
2012
269
0.090
Why?
Superoxide Dismutase
1
2013
301
0.090
Why?
Toll-Like Receptor 4
1
2013
276
0.090
Why?
Cerebellum
1
2013
223
0.080
Why?
Cardiovascular Diseases
2
2021
2168
0.080
Why?
Hydrogen Peroxide
1
2012
336
0.080
Why?
Microcirculation
2
2014
138
0.080
Why?
Blotting, Western
1
2012
1187
0.080
Why?
Sildenafil Citrate
1
2009
60
0.070
Why?
Pneumonia
1
2015
631
0.070
Why?
Active Transport, Cell Nucleus
1
2009
121
0.070
Why?
Hypoxia, Brain
1
2008
9
0.070
Why?
NG-Nitroarginine Methyl Ester
1
2008
49
0.070
Why?
Purines
1
2009
187
0.070
Why?
Mice, Transgenic
2
2025
2182
0.070
Why?
Nitric Oxide Synthase
1
2008
235
0.070
Why?
Epinephrine
1
2008
155
0.070
Why?
Norepinephrine
1
2008
196
0.060
Why?
Hemodynamics
1
2012
1121
0.060
Why?
Female
7
2022
78271
0.060
Why?
Dogs
1
2008
437
0.060
Why?
Mesocricetus
1
2026
46
0.060
Why?
Protein Isoforms
2
2022
402
0.060
Why?
Myocardium
1
2011
939
0.060
Why?
Cricetinae
1
2026
303
0.060
Why?
RNA, Messenger
1
2013
2832
0.060
Why?
Stress Fibers
1
2004
18
0.060
Why?
Stroke Volume
1
2008
651
0.050
Why?
Tissue Distribution
1
2025
327
0.050
Why?
Allyl Compounds
1
2024
26
0.050
Why?
Enzyme Inhibitors
1
2008
824
0.050
Why?
Treatment Outcome
1
2019
11679
0.050
Why?
Sirtuins
1
2024
50
0.050
Why?
Kidney
1
2012
1495
0.050
Why?
Heart Rate
1
2008
855
0.050
Why?
Phenols
1
2024
114
0.050
Why?
p38 Mitogen-Activated Protein Kinases
1
2004
266
0.050
Why?
Actins
1
2004
425
0.050
Why?
Catecholamines
1
2022
87
0.050
Why?
Hypertension
1
2011
1263
0.050
Why?
RNA Splicing Factors
1
2022
64
0.040
Why?
Thrombin
1
2023
166
0.040
Why?
In Situ Hybridization, Fluorescence
1
2022
322
0.040
Why?
Lung Neoplasms
1
2014
2637
0.040
Why?
Lipopolysaccharides
1
2004
863
0.040
Why?
Etanercept
1
2021
60
0.040
Why?
Salmonella enteritidis
1
2001
17
0.040
Why?
Case-Control Studies
2
2018
3604
0.040
Why?
Tumor Necrosis Factor-alpha
1
2004
1217
0.040
Why?
Protein Binding
1
2026
2273
0.040
Why?
Ligands
1
2021
673
0.040
Why?
Arrhythmias, Cardiac
1
2022
361
0.040
Why?
Intracellular Signaling Peptides and Proteins
1
2022
459
0.040
Why?
Fatty Acids
1
2022
450
0.040
Why?
Metabolomics
1
2025
727
0.040
Why?
Erythrocytes
1
2025
757
0.040
Why?
Heart
1
2022
636
0.030
Why?
Guinea Pigs
1
2018
159
0.030
Why?
Linkage Disequilibrium
1
2018
246
0.030
Why?
Tissue Donors
1
2021
424
0.030
Why?
Ventricular Dysfunction, Right
1
2021
248
0.030
Why?
Inflammation Mediators
1
2021
509
0.030
Why?
Cytochrome P-450 Enzyme System
1
2018
162
0.030
Why?
Cytoskeleton
1
2018
195
0.030
Why?
Genetics, Population
1
2018
214
0.030
Why?
Proteins
1
2023
1021
0.030
Why?
Heart Ventricles
2
2012
760
0.030
Why?
Mice, Inbred Strains
2
2014
397
0.030
Why?
Sequence Analysis, RNA
1
2018
442
0.030
Why?
Gene Regulatory Networks
1
2018
318
0.030
Why?
Adenosine
1
2017
255
0.030
Why?
Sarcoma, Experimental
1
2014
6
0.030
Why?
Rats, Nude
1
2014
25
0.030
Why?
Intravital Microscopy
1
2014
25
0.030
Why?
Drug Therapy, Combination
1
2017
1047
0.030
Why?
Heterografts
1
2014
143
0.030
Why?
Coronary Vessels
1
2016
251
0.030
Why?
Models, Biological
1
2021
1821
0.030
Why?
Genotype
1
2018
1833
0.030
Why?
Transcription Factor RelA
1
2014
85
0.020
Why?
Swine
1
2016
833
0.020
Why?
Familial Primary Pulmonary Hypertension
1
2014
197
0.020
Why?
Blood Flow Velocity
1
2014
413
0.020
Why?
Chemistry, Physical
1
2012
39
0.020
Why?
Cytokines
1
2021
2061
0.020
Why?
Neovascularization, Pathologic
1
2014
286
0.020
Why?
Fructans
1
1992
1
0.020
Why?
Genes, Immunoglobulin
1
1992
29
0.020
Why?
Immunoglobulin Variable Region
1
1992
80
0.020
Why?
Immunoglobulin Light Chains
1
1992
51
0.020
Why?
MicroRNAs
1
2018
701
0.020
Why?
Immunoglobulin Heavy Chains
1
1992
85
0.020
Why?
Adult
3
2023
40449
0.020
Why?
Mitochondria
1
2018
984
0.020
Why?
Gene Expression Profiling
1
2018
1782
0.020
Why?
Histone Deacetylase 6
1
2011
17
0.020
Why?
Polymorphism, Single Nucleotide
1
2018
2145
0.020
Why?
Young Adult
2
2018
14105
0.020
Why?
Benzamides
1
2012
224
0.020
Why?
Adenoviridae
1
2011
199
0.020
Why?
Regional Blood Flow
1
2012
514
0.020
Why?
RNA Interference
1
2011
476
0.020
Why?
Pyrimidines
1
2012
532
0.020
Why?
Polymerase Chain Reaction
1
2011
1054
0.020
Why?
Cohort Studies
1
2018
5960
0.020
Why?
Pyridines
1
2012
605
0.020
Why?
Cell Line, Tumor
1
2014
3540
0.020
Why?
Middle Aged
2
2018
35875
0.010
Why?
Antibodies, Monoclonal
1
1992
1519
0.010
Why?
Child
1
2023
22633
0.010
Why?
Breast Neoplasms
1
2014
2452
0.010
Why?
Adolescent
1
2017
22428
0.010
Why?
Antibody Diversity
1
1992
16
0.010
Why?
Immunoglobulin Isotypes
1
1992
35
0.010
Why?
Antibody Specificity
1
1992
181
0.010
Why?
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