Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David Irwin

Concepts (278)

Concepts are derived automatically from a person's publications.

Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.

Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Anemia, Sickle Cell
12
2025
252
5.300
Why?
Hemoglobins
10
2021
339
3.310
Why?
Hemopexin
4
2025
27
1.830
Why?
beta-Thalassemia
2
2025
37
1.740
Why?
Hypertension, Pulmonary
9
2025
1894
1.540
Why?
Hemolysis
6
2025
199
1.320
Why?
Altitude Sickness
4
2016
141
1.230
Why?
Exercise Tolerance
4
2025
273
1.180
Why?
Altitude
4
2022
462
1.150
Why?
Hypoxia
10
2022
1084
1.130
Why?
Heme
3
2025
77
1.120
Why?
Pulmonary Edema
3
2019
106
1.100
Why?
Lung
5
2025
3927
0.940
Why?
Iron
2
2025
281
0.900
Why?
Muscle, Skeletal
4
2025
1613
0.890
Why?
Spleen
1
2025
506
0.810
Why?
Oxygen
5
2024
915
0.800
Why?
Pulmonary Ventilation
1
2022
77
0.780
Why?
Rats
17
2024
5482
0.740
Why?
Haptoglobins
3
2018
52
0.740
Why?
Capillary Permeability
4
2016
140
0.700
Why?
Vascular Remodeling
3
2022
192
0.700
Why?
Animals
35
2025
35309
0.690
Why?
Proteome
1
2025
438
0.690
Why?
Beta vulgaris
1
2020
11
0.690
Why?
Pulmonary Artery
6
2022
1095
0.670
Why?
Rats, Sprague-Dawley
12
2024
2396
0.670
Why?
Endothelium, Vascular
3
2018
901
0.650
Why?
Emulsions
1
2019
51
0.650
Why?
Atrial Natriuretic Factor
3
2005
56
0.650
Why?
Vasodilator Agents
2
2013
326
0.640
Why?
Blood Substitutes
2
2009
24
0.610
Why?
Reactive Oxygen Species
2
2013
596
0.590
Why?
Fluorocarbons
1
2019
109
0.580
Why?
Oxygen Consumption
3
2024
672
0.560
Why?
Physical Exertion
1
2018
205
0.550
Why?
Microvessels
1
2018
82
0.550
Why?
Carbonic Anhydrase Inhibitors
1
2016
14
0.540
Why?
Toll-Like Receptor 9
1
2017
31
0.540
Why?
Cerebral Veins
1
2016
15
0.530
Why?
Disease Models, Animal
11
2025
4057
0.530
Why?
Angiogenesis Inducing Agents
1
2016
24
0.530
Why?
Drug Delivery Systems
1
2019
333
0.530
Why?
Brain Edema
1
2016
60
0.520
Why?
Liver
1
2025
1839
0.520
Why?
Cerebral Arteries
1
2016
60
0.520
Why?
Water
1
2019
441
0.520
Why?
NF-E2-Related Factor 2
2
2013
79
0.500
Why?
Macrophages
2
2023
1484
0.500
Why?
Mice
16
2025
16915
0.490
Why?
Exercise
2
2024
1925
0.470
Why?
Angiogenesis Inhibitors
1
2016
220
0.470
Why?
Muscle Contraction
1
2018
422
0.470
Why?
Endothelial Cells
2
2013
746
0.450
Why?
Transcriptional Activation
2
2013
367
0.430
Why?
Vascular Diseases
2
2015
240
0.420
Why?
Mice, Inbred C57BL
6
2025
5439
0.420
Why?
Myeloid Differentiation Factor 88
1
2013
96
0.410
Why?
Hypoxia-Inducible Factor 1, alpha Subunit
3
2014
274
0.390
Why?
Glutaral
1
2009
15
0.320
Why?
Lung Diseases
2
2015
739
0.320
Why?
Proteomics
3
2025
1054
0.320
Why?
Phosphodiesterase 5 Inhibitors
1
2009
37
0.310
Why?
Phosphodiesterase Inhibitors
1
2009
89
0.310
Why?
Phenylpropionates
2
2019
18
0.310
Why?
Oxidative Stress
4
2025
1266
0.310
Why?
Sulfones
1
2009
108
0.300
Why?
Pyridazines
2
2019
54
0.300
Why?
Male
19
2025
63517
0.290
Why?
Inflammation
3
2023
2737
0.290
Why?
Vascular Resistance
3
2016
370
0.290
Why?
Endothelins
2
2018
62
0.290
Why?
Disease Progression
3
2023
2630
0.290
Why?
Polymers
2
2009
477
0.280
Why?
Piperazines
1
2009
341
0.260
Why?
Lipid Peroxidation
3
2018
151
0.260
Why?
Respiration
2
2022
191
0.260
Why?
Nitric Oxide
3
2018
901
0.260
Why?
Vascular Endothelial Growth Factor A
1
2009
530
0.260
Why?
Cell Nucleus
1
2009
586
0.250
Why?
Physical Conditioning, Animal
2
2025
229
0.250
Why?
Cardiac Output
3
2012
156
0.240
Why?
Capillary Leak Syndrome
1
2005
12
0.240
Why?
Blood Pressure
5
2018
1736
0.240
Why?
Muscle, Smooth, Vascular
4
2017
443
0.240
Why?
Humans
23
2025
129271
0.230
Why?
Lignans
1
2024
13
0.230
Why?
Heme Oxygenase-1
1
2025
62
0.230
Why?
Glucosephosphate Dehydrogenase Deficiency
1
2025
30
0.230
Why?
Neprilysin
1
2005
48
0.230
Why?
Glucosephosphate Dehydrogenase
1
2025
56
0.230
Why?
Biphenyl Compounds
1
2024
60
0.220
Why?
NAD
1
2024
75
0.220
Why?
Sirtuin 3
1
2024
58
0.220
Why?
Aerosols
1
2025
170
0.220
Why?
Intercellular Adhesion Molecule-1
2
2015
135
0.210
Why?
Endothelin-1
1
2005
179
0.210
Why?
Glycolysis
1
2025
311
0.210
Why?
Pulmonary Circulation
2
2019
430
0.200
Why?
Oxidation-Reduction
3
2018
1028
0.200
Why?
Antibodies
2
2021
398
0.190
Why?
Oxyhemoglobins
1
2021
21
0.190
Why?
Magnetics
1
2021
43
0.190
Why?
Scleroderma, Systemic
1
2022
114
0.180
Why?
Extracellular Vesicles
1
2023
129
0.170
Why?
Muscle Proteins
1
2022
220
0.170
Why?
Leukocytes, Mononuclear
1
2023
545
0.170
Why?
Metabolic Diseases
1
2021
104
0.170
Why?
Monocytes
1
2023
551
0.170
Why?
Alternative Splicing
1
2022
216
0.170
Why?
CD40 Antigens
1
2021
88
0.170
Why?
Nitrates
1
2020
88
0.170
Why?
Up-Regulation
2
2013
839
0.170
Why?
RNA, Long Noncoding
1
2022
179
0.160
Why?
Endotoxins
1
2001
220
0.160
Why?
Receptors, G-Protein-Coupled
1
2021
207
0.160
Why?
Histone Deacetylases
2
2012
212
0.160
Why?
Drug Evaluation, Preclinical
1
2019
171
0.160
Why?
Gadolinium
1
2019
78
0.160
Why?
Enoyl-CoA Hydratase
1
2018
8
0.160
Why?
Lipids
2
2023
625
0.150
Why?
Cell Line
2
2015
2779
0.150
Why?
Metabolome
1
2021
338
0.150
Why?
Double-Blind Method
2
2020
1875
0.150
Why?
Blood Gas Analysis
2
2008
71
0.150
Why?
Carrier Proteins
1
2022
742
0.150
Why?
Liver Diseases
1
2021
290
0.140
Why?
Aminophylline
1
2017
10
0.140
Why?
Antioxidants
2
2013
558
0.140
Why?
Lipoproteins
1
2018
171
0.140
Why?
Cells, Cultured
6
2014
4077
0.140
Why?
Anemia, Hemolytic
1
2017
16
0.140
Why?
Deferoxamine
1
2016
20
0.140
Why?
Cell Proliferation
2
2017
2375
0.140
Why?
Acetazolamide
1
2016
24
0.130
Why?
Acclimatization
1
2018
165
0.130
Why?
Mice, Knockout
3
2022
2871
0.130
Why?
Niacinamide
1
2016
75
0.130
Why?
Dietary Supplements
1
2020
534
0.130
Why?
Myocytes, Cardiac
3
2022
499
0.130
Why?
NF-kappa B
2
2013
665
0.120
Why?
Oligonucleotides
1
2016
140
0.120
Why?
Antihypertensive Agents
1
2019
485
0.120
Why?
Methemoglobin
2
2021
20
0.120
Why?
Cardiomyopathy, Dilated
1
2018
381
0.120
Why?
Signal Transduction
5
2017
4926
0.120
Why?
Vasoconstriction
1
2016
199
0.120
Why?
Hypertrophy, Right Ventricular
1
2015
145
0.110
Why?
Chloride Channels
1
2014
38
0.110
Why?
Cattle
2
2008
977
0.110
Why?
Indoles
1
2016
384
0.110
Why?
Genomics
1
2018
717
0.110
Why?
RNA, Small Interfering
3
2012
591
0.110
Why?
Catalase
1
2013
128
0.110
Why?
Cell Membrane Permeability
1
2013
82
0.110
Why?
Permeability
1
2013
157
0.100
Why?
Histone Deacetylase Inhibitors
2
2012
209
0.100
Why?
Interleukin-6
1
2017
720
0.100
Why?
Ventricular Remodeling
2
2012
255
0.100
Why?
Cyclic N-Oxides
1
2012
29
0.100
Why?
Infusion Pumps
1
2012
31
0.100
Why?
Spin Labels
1
2012
46
0.100
Why?
Heart Failure
2
2022
2135
0.100
Why?
Basic Helix-Loop-Helix Transcription Factors
1
2013
235
0.090
Why?
Macrophages, Alveolar
1
2015
389
0.090
Why?
Mitochondrial Proteins
1
2014
248
0.090
Why?
Gene Expression Regulation, Enzymologic
1
2012
286
0.090
Why?
Toll-Like Receptor 4
1
2013
263
0.090
Why?
Cerebellum
1
2013
218
0.090
Why?
Superoxide Dismutase
1
2013
342
0.090
Why?
Cardiovascular Diseases
2
2021
2003
0.090
Why?
Hydrogen Peroxide
1
2012
318
0.090
Why?
Microcirculation
2
2014
145
0.080
Why?
Blotting, Western
1
2012
1204
0.080
Why?
Sildenafil Citrate
1
2009
59
0.080
Why?
Pneumonia
1
2015
616
0.080
Why?
Active Transport, Cell Nucleus
1
2009
113
0.080
Why?
Hypoxia, Brain
1
2008
8
0.070
Why?
NG-Nitroarginine Methyl Ester
1
2008
48
0.070
Why?
Purines
1
2009
172
0.070
Why?
Female
7
2022
68556
0.070
Why?
Mice, Transgenic
2
2025
2117
0.070
Why?
Epinephrine
1
2008
141
0.070
Why?
Nitric Oxide Synthase
1
2008
237
0.070
Why?
Norepinephrine
1
2008
210
0.070
Why?
Hemodynamics
1
2012
1090
0.070
Why?
Dogs
1
2008
382
0.070
Why?
Protein Isoforms
2
2022
389
0.060
Why?
RNA, Messenger
1
2013
2703
0.060
Why?
Myocardium
1
2011
978
0.060
Why?
Treatment Outcome
1
2019
10202
0.060
Why?
Stress Fibers
1
2004
18
0.060
Why?
Stroke Volume
1
2008
592
0.060
Why?
Enzyme Inhibitors
1
2008
827
0.060
Why?
Allyl Compounds
1
2024
21
0.060
Why?
Kidney
1
2012
1385
0.060
Why?
Sirtuins
1
2024
39
0.060
Why?
Heart Rate
1
2008
802
0.060
Why?
Phenols
1
2024
96
0.050
Why?
p38 Mitogen-Activated Protein Kinases
1
2004
275
0.050
Why?
Actins
1
2004
411
0.050
Why?
Catecholamines
1
2022
96
0.050
Why?
RNA Splicing Factors
1
2022
52
0.050
Why?
Hypertension
1
2011
1242
0.050
Why?
Thrombin
1
2023
145
0.050
Why?
Lung Neoplasms
1
2014
2342
0.050
Why?
In Situ Hybridization, Fluorescence
1
2022
313
0.050
Why?
Lipopolysaccharides
1
2004
877
0.050
Why?
Etanercept
1
2021
56
0.040
Why?
Salmonella enteritidis
1
2001
18
0.040
Why?
Case-Control Studies
2
2018
3377
0.040
Why?
Arrhythmias, Cardiac
1
2022
317
0.040
Why?
Tumor Necrosis Factor-alpha
1
2004
1202
0.040
Why?
Ligands
1
2021
621
0.040
Why?
Metabolomics
1
2025
652
0.040
Why?
Erythrocytes
1
2025
673
0.040
Why?
Intracellular Signaling Peptides and Proteins
1
2022
442
0.040
Why?
Fatty Acids
1
2022
427
0.040
Why?
Tissue Donors
1
2021
391
0.040
Why?
Heart
1
2022
637
0.040
Why?
Guinea Pigs
1
2018
157
0.040
Why?
Ventricular Dysfunction, Right
1
2021
231
0.040
Why?
Linkage Disequilibrium
1
2018
257
0.040
Why?
Cytochrome P-450 Enzyme System
1
2018
151
0.040
Why?
Inflammation Mediators
1
2021
505
0.040
Why?
Genetics, Population
1
2018
200
0.040
Why?
Cytoskeleton
1
2018
183
0.040
Why?
Proteins
1
2023
941
0.030
Why?
Gene Regulatory Networks
1
2018
280
0.030
Why?
Sequence Analysis, RNA
1
2018
428
0.030
Why?
Heart Ventricles
2
2012
781
0.030
Why?
Mice, Inbred Strains
2
2014
406
0.030
Why?
Adenosine
1
2017
227
0.030
Why?
Sarcoma, Experimental
1
2014
7
0.030
Why?
Rats, Nude
1
2014
27
0.030
Why?
Intravital Microscopy
1
2014
25
0.030
Why?
Drug Therapy, Combination
1
2017
1040
0.030
Why?
Models, Biological
1
2021
1722
0.030
Why?
Heterografts
1
2014
131
0.030
Why?
Coronary Vessels
1
2016
239
0.030
Why?
Swine
1
2016
760
0.030
Why?
Transcription Factor RelA
1
2014
83
0.030
Why?
Genotype
1
2018
1835
0.030
Why?
Familial Primary Pulmonary Hypertension
1
2014
199
0.030
Why?
Blood Flow Velocity
1
2014
406
0.030
Why?
Adult
3
2023
35497
0.030
Why?
Chemistry, Physical
1
2012
37
0.030
Why?
Cytokines
1
2021
2013
0.030
Why?
Neovascularization, Pathologic
1
2014
296
0.030
Why?
Fructans
1
1992
1
0.020
Why?
Genes, Immunoglobulin
1
1992
28
0.020
Why?
Mitochondria
1
2018
877
0.020
Why?
Immunoglobulin Light Chains
1
1992
40
0.020
Why?
Immunoglobulin Variable Region
1
1992
79
0.020
Why?
Immunoglobulin Heavy Chains
1
1992
80
0.020
Why?
MicroRNAs
1
2018
676
0.020
Why?
Gene Expression Profiling
1
2018
1688
0.020
Why?
Young Adult
2
2018
12392
0.020
Why?
Histone Deacetylase 6
1
2011
17
0.020
Why?
Polymorphism, Single Nucleotide
1
2018
2063
0.020
Why?
Benzamides
1
2012
207
0.020
Why?
Adenoviridae
1
2011
192
0.020
Why?
Phenotype
1
2018
3074
0.020
Why?
Regional Blood Flow
1
2012
463
0.020
Why?
RNA Interference
1
2011
450
0.020
Why?
Pyrimidines
1
2012
459
0.020
Why?
Pyridines
1
2012
478
0.020
Why?
Polymerase Chain Reaction
1
2011
1036
0.020
Why?
Cohort Studies
1
2018
5409
0.020
Why?
Cell Line, Tumor
1
2014
3202
0.020
Why?
Middle Aged
2
2018
31091
0.020
Why?
Antibodies, Monoclonal
1
1992
1367
0.020
Why?
Child
1
2023
20785
0.010
Why?
Breast Neoplasms
1
2014
2140
0.010
Why?
Adolescent
1
2017
20315
0.010
Why?
Antibody Diversity
1
1992
16
0.010
Why?
Immunoglobulin Isotypes
1
1992
34
0.010
Why?
Antibody Specificity
1
1992
184
0.010
Why?
Irwin's Networks
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