 Myristoylated Alanine-Rich C Kinase Substrate
"Myristoylated Alanine-Rich C Kinase Substrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane and ACTIN CYTOSKELETON associated, N-terminal myristoylated protein that binds CALMODULIN and is a prominent substrate for PROTEIN KINASE C. Both phosphorylation and poly(ADP)-ribosylation inhibit its F-ACTIN crosslinking activity; phosphorylation also causes MARCKS to relocate from the membrane to cytoplasm.
| Descriptor ID |
D000076250
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| MeSH Number(s) |
D05.750.078.730.556 D12.644.360.537 D12.776.157.142.375 D12.776.157.687.496 D12.776.220.525.556 D12.776.476.539 D12.776.543.637 D12.776.660.720.496
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Myristoylated Alanine-Rich C Kinase Substrate".
Below are MeSH descriptors whose meaning is more specific than "Myristoylated Alanine-Rich C Kinase Substrate".
This graph shows the total number of publications written about "Myristoylated Alanine-Rich C Kinase Substrate" by people in this website by year, and whether "Myristoylated Alanine-Rich C Kinase Substrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 | | 2016 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Myristoylated Alanine-Rich C Kinase Substrate" by people in Profiles.
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Ziemba BP, Falke JJ. A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. PLoS One. 2018; 13(5):e0196678.
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Kastelowitz N, Tamura R, Onasoga A, Stalker TJ, White OR, Brown PN, Brodsky GL, Brass LF, Branchford BR, Di Paola J, Yin H. Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine. Sci Rep. 2017 06 27; 7(1):4275.
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Ziemba BP, Swisher GH, Masson G, Burke JE, Williams RL, Falke JJ. Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module. Biochemistry. 2016 Nov 22; 55(46):6395-6405.
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de Jesus AJ, White OR, Flynn AD, Yin H. Determinants of Curvature-Sensing Behavior for MARCKS-Fragment Peptides. Biophys J. 2016 05 10; 110(9):1980-92.
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Ziemba BP, Burke JE, Masson G, Williams RL, Falke JJ. Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway. Biophys J. 2016 04 26; 110(8):1811-1825.
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Le-Niculescu H, Levey DF, Ayalew M, Palmer L, Gavrin LM, Jain N, Winiger E, Bhosrekar S, Shankar G, Radel M, Bellanger E, Duckworth H, Olesek K, Vergo J, Schweitzer R, Yard M, Ballew A, Shekhar A, Sandusky GE, Schork NJ, Kurian SM, Salomon DR, Niculescu AB. Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry. 2013 Dec; 18(12):1249-64.
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Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25.
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Estrada-Bernal A, Gatlin JC, Sunpaweravong S, Pfenninger KH. Dynamic adhesions and MARCKS in melanoma cells. J Cell Sci. 2009 Jul 01; 122(Pt 13):2300-10.
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Gatlin JC, Estrada-Bernal A, Sanford SD, Pfenninger KH. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Mol Biol Cell. 2006 Dec; 17(12):5115-30.
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