 p21-Activated Kinases
"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
| Descriptor ID |
D054462
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| MeSH Number(s) |
D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
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| Concept/Terms |
p21-Activated Kinases- p21-Activated Kinases
- Kinases, p21-Activated
- p21 Activated Kinases
- PAK Kinases
- Kinases, PAK
p21-Activated Kinase 2- p21-Activated Kinase 2
- p21 Activated Kinase 2
- p65(PAK)
- p65PAK Protein
- PAK-2 Kinase
- PAK 2 Kinase
- PAK2 Kinase
- PAK65
- gamma-PAK
- gamma PAK
p21-Activated Kinase 1- p21-Activated Kinase 1
- p21 Activated Kinase 1
- Serine-Threonine-Protein Kinase PAK 1
- Serine Threonine Protein Kinase PAK 1
- alpha p21-Activated Kinase
- alpha p21 Activated Kinase
- alpha-PAK
- PAK1 Kinase
- PAK-1 Kinase
- PAK 1 Kinase
p21-Activated Kinase 3- p21-Activated Kinase 3
- p21 Activated Kinase 3
- Oligophrenin-3
- Oligophrenin 3
- Serine-Threonine-Protein Kinase PAK 3
- Serine Threonine Protein Kinase PAK 3
- PAK3 Kinase
- beta p21-Activated Kinase
- beta p21 Activated Kinase
- p21-Activated Kinase, beta
- beta-PAK
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Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".
Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".
This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2011 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.
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Kathania M, Kumar R, Lenou ET, Basrur V, Theiss AL, Chernoff J, Venuprasad K. Pak2-mediated phosphorylation promotes ROR?t ubiquitination and inhibits colonic inflammation. Cell Rep. 2022 09 13; 40(11):111345.
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Brown TL, Hashimoto H, Finseth LT, Wood TL, Macklin WB. PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination. J Neurosci. 2021 03 03; 41(9):1864-1877.
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Korobeynikov V, Borakove M, Feng Y, Wuest WM, Koval AB, Nikonova AS, Serebriiskii I, Chernoff J, Borges VF, Golemis EA, Shagisultanova E. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Res Treat. 2019 Sep; 177(2):369-382.
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Grace PM, Fabisiak TJ, Green-Fulgham SM, Anderson ND, Strand KA, Kwilasz AJ, Galer EL, Walker FR, Greenwood BN, Maier SF, Fleshner M, Watkins LR. Prior voluntary wheel running attenuates neuropathic pain. Pain. 2016 09; 157(9):2012-23.
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Black JL, Harrell JC, Leisner TM, Fellmeth MJ, George SD, Reinhold D, Baker NM, Jones CD, Der CJ, Perou CM, Parise LV. CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. Breast Cancer Res Treat. 2015 Jul; 152(2):337-46.
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Moorman VR, Valentine KG, B?dard S, Kasinath V, Dogan J, Love FM, Wand AJ. Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3. J Mol Biol. 2014 Oct 23; 426(21):3520-38.
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Avvakumov N, Lalonde ME, Saksouk N, Paquet E, Glass KC, Landry AJ, Doyon Y, Cayrou C, Robitaille GA, Richard DE, Yang XJ, Kutateladze TG, C?t? J. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Mol Cell Biol. 2012 Feb; 32(3):689-703.
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Meshki J, Douglas SD, Hu M, Leeman SE, Tuluc F. Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. PLoS One. 2011; 6(9):e25332.
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Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, M?ller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, M?nch J. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol. 2004 Jul; 78(13):6864-74.
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Mainiero F, Soriani A, Strippoli R, Jacobelli J, Gismondi A, Piccoli M, Frati L, Santoni A. RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells. Immunity. 2000 Jan; 12(1):7-16.
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