 ZAP-70 Protein-Tyrosine Kinase
"ZAP-70 Protein-Tyrosine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.
| Descriptor ID |
D051746
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| MeSH Number(s) |
D08.811.913.696.620.682.725.900 D12.776.476.950
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| Concept/Terms |
ZAP-70 Protein-Tyrosine Kinase- ZAP-70 Protein-Tyrosine Kinase
- Protein-Tyrosine Kinase, ZAP-70
- ZAP 70 Protein Tyrosine Kinase
- ZAP-70 Kinase
- Kinase, ZAP-70
- ZAP 70 Kinase
- zeta-Chain Associated Protein Kinase (ZAP-70)
- 70 kDa Zeta-Associated Protein
- 70 kDa Zeta Associated Protein
- ZAP-70 Protein
- ZAP 70 Protein
- Syk-Related Tyrosine Kinase
- Syk Related Tyrosine Kinase
- Tyrosine Kinase, Syk-Related
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Below are MeSH descriptors whose meaning is more general than "ZAP-70 Protein-Tyrosine Kinase".
Below are MeSH descriptors whose meaning is more specific than "ZAP-70 Protein-Tyrosine Kinase".
This graph shows the total number of publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in this website by year, and whether "ZAP-70 Protein-Tyrosine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "ZAP-70 Protein-Tyrosine Kinase" by people in Profiles.
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Pugh JL, Nemat-Gorgani N, Norman PJ, Guethlein LA, Parham P. Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage. J Immunol. 2018 02 01; 200(3):1146-1158.
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Sarhan D, Cichocki F, Zhang B, Yingst A, Spellman SR, Cooley S, Verneris MR, Blazar BR, Miller JS. Adaptive NK Cells with Low TIGIT Expression Are Inherently Resistant to Myeloid-Derived Suppressor Cells. Cancer Res. 2016 10 01; 76(19):5696-5706.
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Osborne DG, Wetzel SA. Trogocytosis results in sustained intracellular signaling in CD4(+) T cells. J Immunol. 2012 Nov 15; 189(10):4728-39.
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Kremer KN, Kumar A, Hedin KE. G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. J Immunol. 2011 Sep 15; 187(6):3177-85.
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Peterson LK, Shaw LA, Joetham A, Sakaguchi S, Gelfand EW, Dragone LL. SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice. J Immunol. 2011 Feb 15; 186(4):2273-81.
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Tabaczewski P, Nadesan S, Lim SH. Zap-70 positive chronic lymphocytic leukemia co-existing with Jak 2 V671F positive essential thrombocythemia: a common defective stem cell? Leuk Res. 2009 Jun; 33(6):854-5.
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Chen Z, Chen L, Qiao SW, Nagaishi T, Blumberg RS. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. J Immunol. 2008 May 01; 180(9):6085-93.
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Kumar A, Humphreys TD, Kremer KN, Bramati PS, Bradfield L, Edgar CE, Hedin KE. CXCR4 physically associates with the T cell receptor to signal in T cells. Immunity. 2006 Aug; 25(2):213-24.
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Guyer BJ, Shimamoto SR, Bradhurst AL, Grossbard EB, Dreskin SC, Nelson HS. Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis. Allergy Asthma Proc. 2006 May-Jun; 27(3):208-13.
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Kremer KN, Humphreys TD, Kumar A, Qian NX, Hedin KE. Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine. J Immunol. 2003 Jul 01; 171(1):360-7.
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