 Disks Large Homolog 4 Protein
"Disks Large Homolog 4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
| Descriptor ID |
D000076122
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| MeSH Number(s) |
D08.811.913.696.650.450.750 D12.644.360.265 D12.776.476.265 D12.776.543.219 D12.776.631.224
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| Concept/Terms |
Disks Large Homolog 4 Protein- Disks Large Homolog 4 Protein
- Postsynaptic Density Protein 95
- Discs Large Homolog 4 Protein
- SAP-90 Protein
- SAP 90 Protein
- PSD95 Protein
- PSD-95 Protein
- PSD 95 Protein
- Synapse-Associated Protein 90
- Synapse Associated Protein 90
- SAP90 Protein
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Below are MeSH descriptors whose meaning is more general than "Disks Large Homolog 4 Protein".
Below are MeSH descriptors whose meaning is more specific than "Disks Large Homolog 4 Protein".
This graph shows the total number of publications written about "Disks Large Homolog 4 Protein" by people in this website by year, and whether "Disks Large Homolog 4 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 2 | 0 | 2 | | 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Disks Large Homolog 4 Protein" by people in Profiles.
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Muscat SM, Deems NP, Butler MJ, Scaria EA, Bettes MN, Cleary SP, Bockbrader RH, Maier SF, Barrientos RM. Selective TLR4 Antagonism Prevents and Reverses Morphine-Induced Persistent Postoperative Cognitive Dysfunction, Dysregulation of Synaptic Elements, and Impaired BDNF Signaling in Aged Male Rats. J Neurosci. 2023 01 04; 43(1):155-172.
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Hill MD, Goyal M, Menon BK, Nogueira RG, McTaggart RA, Demchuk AM, Poppe AY, Buck BH, Field TS, Dowlatshahi D, van Adel BA, Swartz RH, Shah RA, Sauvageau E, Zerna C, Ospel JM, Joshi M, Almekhlafi MA, Ryckborst KJ, Lowerison MW, Heard K, Garman D, Haussen D, Cutting SM, Coutts SB, Roy D, Rempel JL, Rohr AC, Iancu D, Sahlas DJ, Yu AYX, Devlin TG, Hanel RA, Puetz V, Silver FL, Campbell BCV, Chapot R, Teitelbaum J, Mandzia JL, Kleinig TJ, Turkel-Parrella D, Heck D, Kelly ME, Bharatha A, Bang OY, Jadhav A, Gupta R, Frei DF, Tarpley JW, McDougall CG, Holmin S, Rha JH, Puri AS, Camden MC, Thomalla G, Choe H, Phillips SJ, Schindler JL, Thornton J, Nagel S, Heo JH, Sohn SI, Psychogios MN, Budzik RF, Starkman S, Martin CO, Burns PA, Murphy S, Lopez GA, English J, Tymianski M. Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. Lancet. 2020 03 14; 395(10227):878-887.
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Gutierrez MA, Dwyer BE, Franco SJ. Csmd2 Is a Synaptic Transmembrane Protein that Interacts with PSD-95 and Is Required for Neuronal Maturation. eNeuro. 2019 Mar/Apr; 6(2).
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Cook SG, Goodell DJ, Restrepo S, Arnold DB, Bayer KU. Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment. Cell Rep. 2019 04 16; 27(3):658-665.e4.
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Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 11 04; 6(1):115.
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Ploense KL, Vieira P, Bubalo L, Olivarria G, Carr AE, Szumlinski KK, Kippin TE. Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression. Psychopharmacology (Berl). 2018 05; 235(5):1347-1359.
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Smith KR, Jones KA, Kopeikina KJ, Burette AC, Copits BA, Yoon S, Forrest MP, Fawcett-Patel JM, Hanley JG, Weinberg RJ, Swanson GT, Penzes P. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. J Neurosci. 2017 11 15; 37(46):11127-11139.
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Caffino L, Giannotti G, Mottarlini F, Racagni G, Fumagalli F. Developmental Exposure to Cocaine Dynamically Dysregulates Cortical Arc/Arg3.1 Modulation in Response to a Challenge. Neurotox Res. 2017 02; 31(2):289-297.
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Goodell DJ, Ahern MA, Baynard J, Wall VL, Bland ST. A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat. Behav Brain Res. 2017 01 15; 317:1-15.
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Vlasits AL, Morrie RD, Tran-Van-Minh A, Bleckert A, Gainer CF, DiGregorio DA, Feller MB. A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina. Neuron. 2016 Mar 16; 89(6):1317-1330.
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