Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Ding Xue

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-0271

    Collapse Research 
    Collapse research activities and funding
    R35GM118188     (XUE, DING)Jun 1, 2016 - May 31, 2026
    NIH
    Fundamental mechanisms of paternal mitochondrial eliminationand radiation-induced bystander effects
    Role: Principal Investigator
    R01GM088241     (XUE, DING)Jul 19, 2010 - May 31, 2016
    NIH
    Regulation of Cell Death Activation
    Role: Principal Investigator
    R01GM079097     (XUE, DING)Mar 1, 2007 - May 31, 2016
    NIH
    Chromatin Degradation During Apoptosis
    Role: Principal Investigator
    R01GM066262     (XUE, DING)Sep 1, 2002 - Aug 31, 2007
    NIH
    Regulation of Sexually Dimorphic Apoptosis
    Role: Principal Investigator
    R01GM059083     (XUE, DING)Jul 1, 1999 - Feb 28, 2015
    NIH
    Targets of the Cell Death Proteases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. An X, Li Z, Wang X, Lu W, Wen X, Feng M, Liu Q, Wei Z, Hu JS, Xue DJ. Photovoltaic Absorber "Glues" for Efficient Bifacial Selenium Photovoltaics. Angew Chem Int Ed Engl. 2025 Jun 10; 64(24):e202505297. PMID: 40192568.
      View in: PubMed
    2. Redweik G, Xue D. Secreted autotransporter toxin produced by probiotic Escherichia coli Nissle 1917 enhances neurodegeneration in Caenorhabditis elegans. MicroPubl Biol. 2025; 2025. PMID: 39950089.
      View in: PubMed
    3. Wang S, Xue D. Asymmetric partitioning of persistent paternal mitochondria during cell divisions safeguards embryo development and mitochondrial inheritance. Dev Cell. 2025 Jan 30. PMID: 39904343.
      View in: PubMed
    4. Qu X, Zhang H, Gao T, Zhang F, Zhang Y, Xue DJ, Liu Y. Determinants of regioselectivity of heterostructures in cation exchange reactions. Chem Sci. 2025 Jan 15; 16(3):1432-1440. PMID: 39713757.
      View in: PubMed
    5. Liu Q, Wang X, Li Z, Lu W, Wen X, An X, Feng M, Yan HJ, Hu JS, Xue DJ. Standing 1D Chains Enable Efficient Wide-Bandgap Selenium Solar Cells. Adv Mater. 2025 Jan; 37(1):e2410835. PMID: 39506396.
      View in: PubMed
    6. Zhang H, Zhu Y, Xue D. Moderate embryonic delay of paternal mitochondrial elimination impairs mating and cognition and alters behaviors of adult animals. Sci Adv. 2024 Oct 04; 10(40):eadp8351. PMID: 39365857.
      View in: PubMed
    7. Li Z, An X, Wang X, Lu W, Wen X, Zhang X, Xue DJ. Unusual defect properties of the one-dimensional photovoltaic semiconductor selenium. Chem Commun (Camb). 2024 Oct 01; 60(79):11092-11095. PMID: 39279502.
      View in: PubMed
    8. Yang H, Zhang H, Guo L, Yang W, Wu Y, Wang J, Li X, Du H, Peng B, Liu Q, Wang F, Xue DJ, Xu X. Template Selection Strategy for Synthesis of One-Dimensional CrSbSe3 Ferromagnetic Semiconductor Nanoribbons. Nano Lett. 2024 Aug 28; 24(34):10519-10526. PMID: 39150339.
      View in: PubMed
    9. Wang X, Li Z, Jin B, Lu W, Feng M, Dong B, Liu Q, Yan HJ, Wang SM, Xue DJ. Sustainable Recycling of Selenium-Based Optoelectronic Devices. Adv Sci (Weinh). 2024 Jun; 11(22):e2400615. PMID: 38489666.
      View in: PubMed
    10. Zhang H, Zhu Y, Suehiro Y, Mitani S, Xue D. AMPK-FOXO-IP3R signaling pathway mediates neurological and developmental defects caused by mitochondrial DNA mutations. Proc Natl Acad Sci U S A. 2023 09 05; 120(36):e2302490120. PMID: 37639584.
      View in: PubMed
    11. Bhadra J, Sridhar N, Fajrial AK, Hammond N, Xue D, Ding X. Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in C. elegans. Sci Adv. 2023 02 22; 9(8):eadf5056. PMID: 36812319.
      View in: PubMed
    12. Chen Y, Lu Z, Qi C, Yu C, Li Y, Huan W, Wang R, Luo W, Shen D, Ding L, Ren L, Xie H, Xue D, Wang M, Ni K, Xia L, Qian J, Li G. N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. Mol Cancer. 2022 05 10; 21(1):111. PMID: 35538475.
      View in: PubMed
    13. Hu L, Feng M, Wang X, Liu S, Wu J, Yan B, Lu W, Wang F, Hu JS, Xue DJ. Solution-processed Ge(ii)-based chalcogenide thin films with tunable bandgaps for photovoltaics. Chem Sci. 2022 May 25; 13(20):5944-5950. PMID: 35685789.
      View in: PubMed
    14. Li Z, Yan HJ, Liu X, Liu S, Feng M, Wang X, Yan B, Xue DJ. Surface-Defect States in Photovoltaic Absorber GeSe. J Phys Chem Lett. 2021 Oct 28; 12(42):10249-10254. PMID: 34648285.
      View in: PubMed
    15. Wang F, Yang H, Zhang H, Zhou J, Wang J, Hu L, Xue DJ, Xu X. One-Pot Synthesis Enables Magnetic Coupled Cr2Te3/MnTe/Cr2Te3 Integrated Heterojunction Nanorods. Nano Lett. 2021 Sep 22; 21(18):7684-7690. PMID: 34435772.
      View in: PubMed
    16. Xia L, Shen D, Zhang Y, Lu J, Wang M, Wang H, Chen Y, Xue D, Xie D, Li G. Targeting the TR4 nuclear receptor with antagonist bexarotene can suppress the proopiomelanocortin signalling in AtT-20 cells. J Cell Mol Med. 2021 03; 25(5):2404-2417. PMID: 33491272.
      View in: PubMed
    17. Wang H, Wang L, Zheng Q, Lu Z, Chen Y, Shen D, Xue D, Jiang M, Ding L, Zhang J, Wu H, Xia L, Qian J, Li G, Lu J. Oncometabolite L-2-hydroxyglurate directly induces vasculogenic mimicry through PHLDB2 in renal cell carcinoma. Int J Cancer. 2021 04 01; 148(7):1743-1755. PMID: 33320958.
      View in: PubMed
    18. Yang H, Wang F, Zhang H, Guo L, Hu L, Wang L, Xue DJ, Xu X. Solution Synthesis of Layered van der Waals (vdW) Ferromagnetic CrGeTe3 Nanosheets from a Non-vdW Cr2Te3Template. J Am Chem Soc. 2020 Mar 04; 142(9):4438-4444. PMID: 31976663.
      View in: PubMed
    19. Li Z, Liu X, Wang X, Yang Y, Liu SC, Shi W, Li Y, Xing X, Xue DJ, Hu JS. Strain-engineering the in-plane electrical anisotropy of GeSe monolayers. Phys Chem Chem Phys. 2020 Jan 02; 22(2):914-918. PMID: 31845940.
      View in: PubMed
    20. Chen Y, Jiang S, Lu Z, Xue D, Xia L, Lu J, Wang H, Xu L, Li L, Li G. Development and verification of a nomogram for prediction of recurrence-free survival in clear cell renal cell carcinoma. J Cell Mol Med. 2020 01; 24(2):1245-1255. PMID: 31782902.
      View in: PubMed
    21. Xue D, Wang H, Chen Y, Shen D, Lu J, Wang M, Zebibula A, Xu L, Wu H, Li G, Xia L. Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals. Mol Cancer. 2019 11 01; 18(1):151. PMID: 31672157.
      View in: PubMed
    22. Liu SC, Li Z, Yang Y, Wang X, Chen YX, Xue DJ, Hu JS. Investigation of Oxygen Passivation for High-Performance All-Inorganic Perovskite Solar Cells. J Am Chem Soc. 2019 Nov 13; 141(45):18075-18082. PMID: 31638806.
      View in: PubMed
    23. Li Z, Yang Y, Wang X, Shi W, Xue DJ, Hu JS. Three-Dimensional Optical Anisotropy of Low-Symmetry Layered GeS. ACS Appl Mater Interfaces. 2019 Jul 10; 11(27):24247-24253. PMID: 31246410.
      View in: PubMed
    24. Chen YZ, Kl?ditz K, Lee ES, Nguyen DP, Yuan Q, Johnson J, Lee-Yow Y, Hall A, Mitani S, Xia NS, Fadeel B, Xue D. Structure and function analysis of the C. elegans aminophospholipid translocase TAT-1. J Cell Sci. 2019 02 28; 132(5). PMID: 30683797.
      View in: PubMed
    25. Yang Y, Wang X, Liu SC, Li Z, Sun Z, Hu C, Xue DJ, Zhang G, Hu JS. Weak Interlayer Interaction in 2D Anisotropic GeSe2. Adv Sci (Weinh). 2019 Mar 06; 6(5):1801810. PMID: 30886804.
      View in: PubMed
    26. Li Z, Wang X, Shi W, Xing X, Xue DJ, Hu JS. Strain-engineering the electronic properties and anisotropy of GeSe2 monolayers. RSC Adv. 2018 Sep 24; 8(58):33445-33450. PMID: 35548125.
      View in: PubMed
    27. Yang Y, Liu SC, Yang W, Li Z, Wang Y, Wang X, Zhang S, Zhang Y, Long M, Zhang G, Xue DJ, Hu JS, Wan LJ. Air-Stable In-Plane Anisotropic GeSe2 for Highly Polarization-Sensitive Photodetection in Short Wave Region. J Am Chem Soc. 2018 03 21; 140(11):4150-4156. PMID: 29494139.
      View in: PubMed
    28. Chen Y, Lu J, Xia L, Xue D, Yu X, Shen D, Xu L, Li G. Testicular orphan receptor 4 promotes tumor progression and implies poor survival through AKT3 regulation in seminoma. Cancer Sci. 2018 Feb; 109(2):384-394. PMID: 29197138.
      View in: PubMed
    29. Smith CE, Soti S, Jones TA, Nakagawa A, Xue D, Yin H. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16; 24(3):281-292. PMID: 28238723.
      View in: PubMed
    30. Chen YX, Ge QQ, Shi Y, Liu J, Xue DJ, Ma JY, Ding J, Yan HJ, Hu JS, Wan LJ. General Space-Confined On-Substrate Fabrication of Thickness-Adjustable Hybrid Perovskite Single-Crystalline Thin Films. J Am Chem Soc. 2016 12 21; 138(50):16196-16199. PMID: 27998083.
      View in: PubMed
    31. Conradt B, Wu YC, Xue D. Programmed Cell Death During Caenorhabditis elegans Development. Genetics. 2016 08; 203(4):1533-62. PMID: 27516615.
      View in: PubMed
    32. Zhou Q, Li H, Li H, Nakagawa A, Lin JL, Lee ES, Harry BL, Skeen-Gaar RR, Suehiro Y, William D, Mitani S, Yuan HS, Kang BH, Xue D. Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Science. 2016 Jul 22; 353(6297):394-9. PMID: 27338704.
      View in: PubMed
    33. Seervi M, Xue D. Mitochondrial Cell Death Pathways in Caenorhabiditis elegans. Curr Top Dev Biol. 2015; 114:43-65. PMID: 26431563.
      View in: PubMed
    34. Yang H, Chen YZ, Zhang Y, Wang X, Zhao X, Godfroy JI, Liang Q, Zhang M, Zhang T, Yuan Q, Ann Royal M, Driscoll M, Xia NS, Yin H, Xue D. A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun. 2015 Jan 07; 6:5717. PMID: 25564762.
      View in: PubMed
    35. Sullivan KD, Nakagawa A, Xue D, Espinosa JM. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle. 2015; 14(12):1771-8. PMID: 25853217.
      View in: PubMed
    36. Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife. 2014 Dec 30; 3:e04265. PMID: 25432023.
      View in: PubMed
    37. Nakagawa A, Sullivan KD, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014 Dec; 21(12):1082-90. PMID: 25383666.
      View in: PubMed
    38. Lee ES, Xue D. Caspase protocols in Caenorhabditis elegans. Methods Mol Biol. 2014; 1133:101-8. PMID: 24567097.
      View in: PubMed
    39. Chen YZ, Mapes J, Lee ES, Skeen-Gaar RR, Xue D. Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization. Nat Commun. 2013; 4:2726. PMID: 24225442.
      View in: PubMed
    40. Morton LA, Yang H, Saludes JP, Fiorini Z, Beninson L, Chapman ER, Fleshner M, Xue D, Yin H. MARCKS-ED peptide as a curvature and lipid sensor. ACS Chem Biol. 2013 Jan 18; 8(1):218-25. PMID: 23075500.
      View in: PubMed
    41. Geng X, Harry BL, Zhou Q, Skeen-Gaar RR, Ge X, Lee ES, Mitani S, Xue D. Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18465-70. PMID: 23091037.
      View in: PubMed
    42. Geng X, Huang C, Qin Y, McCombs JE, Yuan Q, Harry BL, Palmer AE, Xia NS, Xue D. Hepatitis B virus X protein targets Bcl-2 proteins to increase intracellular calcium, required for virus replication and cell death induction. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18471-6. PMID: 23091012.
      View in: PubMed
    43. Mapes J, Chen YZ, Kim A, Mitani S, Kang BH, Xue D. CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol. 2012 Jul 24; 22(14):1267-75. PMID: 22727702.
      View in: PubMed
    44. Zhou Q, Li H, Xue D. Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Res. 2011 Dec; 21(12):1662-9. PMID: 22105480.
      View in: PubMed
    45. Mapes J, Chen JT, Yu JS, Xue D. Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18022-7. PMID: 20921392.
      View in: PubMed
    46. Wang X, Li W, Zhao D, Liu B, Shi Y, Chen B, Yang H, Guo P, Geng X, Shang Z, Peden E, Kage-Nakadai E, Mitani S, Xue D. Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol. 2010 Jul; 12(7):655-64. PMID: 20526330.
      View in: PubMed
    47. Nakagawa A, Shi Y, Kage-Nakadai E, Mitani S, Xue D. Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science. 2010 Apr 16; 328(5976):327-34. PMID: 20223951.
      View in: PubMed
    48. Lai HJ, Lo SJ, Kage-Nakadai E, Mitani S, Xue D. The roles and acting mechanism of Caenorhabditis elegans DNase II genes in apoptotic dna degradation and development. PLoS One. 2009 Oct 07; 4(10):e7348. PMID: 19809494.
      View in: PubMed
    49. Geng X, Zhou QH, Kage-Nakadai E, Shi Y, Yan N, Mitani S, Xue D. Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells. Cell Death Differ. 2009 Oct; 16(10):1385-94. PMID: 19575016.
      View in: PubMed
    50. Breckenridge DG, Kang BH, Xue D. Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans. Curr Biol. 2009 May 12; 19(9):768-73. PMID: 19327994.
      View in: PubMed
    51. Geng X, Shi Y, Nakagawa A, Yoshina S, Mitani S, Shi Y, Xue D. Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat Struct Mol Biol. 2008 Oct; 15(10):1094-101. PMID: 18776901.
      View in: PubMed
    52. Breckenridge DG, Kang BH, Kokel D, Mitani S, Staehelin LA, Xue D. Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell. 2008 Aug 22; 31(4):586-597. PMID: 18722182.
      View in: PubMed
    53. Peden E, Killian DJ, Xue D. Cell death specification in C. elegans. Cell Cycle. 2008 Aug 15; 7(16):2479-84. PMID: 18719375.
      View in: PubMed
    54. Killian DJ, Harvey E, Johnson P, Otori M, Mitani S, Xue D. SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans. Dev Biol. 2008 Oct 15; 322(2):322-31. PMID: 18718460.
      View in: PubMed
    55. Darland-Ransom M, Wang X, Sun CL, Mapes J, Gengyo-Ando K, Mitani S, Xue D. Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science. 2008 Apr 25; 320(5875):528-31. PMID: 18436785.
      View in: PubMed
    56. Peden E, Kimberly E, Gengyo-Ando K, Mitani S, Xue D. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev. 2007 Dec 01; 21(23):3195-207. PMID: 18056429.
      View in: PubMed
    57. Wang X, Wang J, Gengyo-Ando K, Gu L, Sun CL, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie XS, Xue D. C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol. 2007 May; 9(5):541-9. PMID: 17401362.
      View in: PubMed
    58. Xue D, Elliott CM, Gong P, Grainger DW, Bignozzi CA, Caramori S. Indirect electrochemical sensing of DNA hybridization based on the catalytic oxidation of cobalt (II). J Am Chem Soc. 2007 Feb 21; 129(7):1854-5. PMID: 17260990.
      View in: PubMed
    59. Kokel D, Xue D. A class of benzenoid chemicals suppresses apoptosis in C. elegans. Chembiochem. 2006 Dec; 7(12):2010-5. PMID: 17051661.
      View in: PubMed
    60. Kokel D, Li Y, Qin J, Xue D. The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans. Nat Chem Biol. 2006 Jun; 2(6):338-45. PMID: 16699520.
      View in: PubMed
    61. Yang C, Yan N, Parish J, Wang X, Shi Y, Xue D. RNA aptamers targeting the cell death inhibitor CED-9 induce cell killing in Caenorhabditis elegans. J Biol Chem. 2006 Apr 07; 281(14):9137-44. PMID: 16467303.
      View in: PubMed
    62. Parrish JZ, Xue D. Cuts can kill: the roles of apoptotic nucleases in cell death and animal development. Chromosoma. 2006 Apr; 115(2):89-97. PMID: 16418867.
      View in: PubMed
    63. Breckenridge DG, Xue D. Regulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases. Curr Opin Cell Biol. 2004 Dec; 16(6):647-52. PMID: 15530776.
      View in: PubMed
    64. Friedman J, Xue D. To live or die by the sword: the regulation of apoptosis by the proteasome. Dev Cell. 2004 Apr; 6(4):460-1. PMID: 15068786.
      View in: PubMed
    65. Wang X, Wu YC, Fadok VA, Lee MC, Gengyo-Ando K, Cheng LC, Ledwich D, Hsu PK, Chen JY, Chou BK, Henson P, Mitani S, Xue D. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science. 2003 Nov 28; 302(5650):1563-6. PMID: 14645848.
      View in: PubMed
    66. Parrish JZ, Yang C, Shen B, Xue D. CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation. EMBO J. 2003 Jul 01; 22(13):3451-60. PMID: 12840007.
      View in: PubMed
    67. Parrish JZ, Xue D. Functional genomic analysis of apoptotic DNA degradation in C. elegans. Mol Cell. 2003 Apr; 11(4):987-96. PMID: 12718884.
      View in: PubMed
    68. Wang X, Yang C, Chai J, Shi Y, Xue D. Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science. 2002 Nov 22; 298(5598):1587-92. PMID: 12446902.
      View in: PubMed
    69. Parrish J, Li L, Klotz K, Ledwich D, Wang X, Xue D. Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature. 2001 Jul 05; 412(6842):90-4. PMID: 11452313.
      View in: PubMed
    70. Parrish J, Metters H, Chen L, Xue D. Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11916-21. PMID: 11027303.
      View in: PubMed
    71. Ledwich D, Wu YC, Driscoll M, Xue D. Analysis of programmed cell death in the nematode Caenorhabditis elegans. Methods Enzymol. 2000; 322:76-88. PMID: 10914006.
      View in: PubMed
    Xue's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (298) concept(s)
    _
    Co-Authors Expand Description
    See all (6) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2025 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)