 WNK Lysine-Deficient Protein Kinase 1
"WNK Lysine-Deficient Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
| Descriptor ID |
D000076204
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| MeSH Number(s) |
D08.811.913.696.620.682.700.982 D12.644.360.975 D12.776.476.944 D23.050.301.500.600.962 D23.050.705.552.600.925
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "WNK Lysine-Deficient Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "WNK Lysine-Deficient Protein Kinase 1".
This graph shows the total number of publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in this website by year, and whether "WNK Lysine-Deficient Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2010 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in Profiles.
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Mulkearns-Hubert EE, Hajdari N, Hong ES, Jacobs AP, Gaboriau A, Giltner S, Tannish G, Kay KE, Wang SZ, LaViolette PS, Silver DJ, Hubert CG, Dhawan A, Lathia JD. Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis. Cell Rep. 2025 Sep 23; 44(9):116303.
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Furgeson SB, Linas S. Mechanisms of type I and type II pseudohypoaldosteronism. J Am Soc Nephrol. 2010 Nov; 21(11):1842-5.
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