 Focal Adhesion Protein-Tyrosine Kinases
"Focal Adhesion Protein-Tyrosine Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of non-receptor, PROLINE-rich protein-tyrosine kinases.
| Descriptor ID |
D051416
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| MeSH Number(s) |
D08.811.913.696.620.682.725.049 D12.644.360.287 D12.776.476.287
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| Concept/Terms |
Focal Adhesion Protein-Tyrosine Kinases- Focal Adhesion Protein-Tyrosine Kinases
- Focal Adhesion Protein Tyrosine Kinases
- Focal Adhesion Protein-Tyrosine Kinase Family
- Focal Adhesion Protein Tyrosine Kinase Family
- Focal Adhesion Kinase
- Focal Adhesion Protein-Tyrosine Kinase
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Below are MeSH descriptors whose meaning is more general than "Focal Adhesion Protein-Tyrosine Kinases".
Below are MeSH descriptors whose meaning is more specific than "Focal Adhesion Protein-Tyrosine Kinases".
This graph shows the total number of publications written about "Focal Adhesion Protein-Tyrosine Kinases" by people in this website by year, and whether "Focal Adhesion Protein-Tyrosine Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2003 | 0 | 4 | 4 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 1 | 2 | 3 | | 2017 | 1 | 1 | 2 | | 2019 | 0 | 2 | 2 | | 2020 | 2 | 0 | 2 | | 2022 | 0 | 2 | 2 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Focal Adhesion Protein-Tyrosine Kinases" by people in Profiles.
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Pacheco GG, Dzamba BJ, Endo W, Edwards BC, Khan M, Comlekoglu T, Shook DR, Quasey K, Bjerke MA, Hirsh GD, Kashatus DF, DeSimone DW. Spatial regulation of mitochondrial membrane potential by a5ß1 integrin engagement in collective cell migration. J Cell Sci. 2025 May 01; 138(9).
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Gao S, He L, Lam CK, Taylor MRG, Mestroni L, Lombardi R, Chen SN. Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells. 2024 02 02; 13(3).
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Brastianos PK, Twohy EL, Gerstner ER, Kaufmann TJ, Iafrate AJ, Lennerz J, Jeyapalan S, Piccioni DE, Monga V, Fadul CE, Schiff D, Taylor JW, Chowdhary SA, Bettegowda C, Ansstas G, De La Fuente M, Anderson MD, Shonka N, Damek D, Carrillo J, Kunschner-Ronan LJ, Chaudhary R, Jaeckle KA, Senecal FM, Kaley T, Morrison T, Thomas AA, Welch MR, Iwamoto F, Cachia D, Cohen AL, Vora S, Knopp M, Dunn IF, Kumthekar P, Sarkaria J, Geyer S, Carrero XW, Martinez-Lage M, Cahill DP, Brown PD, Giannini C, Santagata S, Barker FG, Galanis E. Alliance A071401: Phase II Trial of Focal Adhesion Kinase Inhibition in Meningiomas With Somatic NF2 Mutations. J Clin Oncol. 2023 01 20; 41(3):618-628.
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Qian X, DeGennaro EM, Talukdar M, Akula SK, Lai A, Shao DD, Gonzalez D, Marciano JH, Smith RS, Hylton NK, Yang E, Bazan JF, Barrett L, Yeh RC, Hill RS, Beck SG, Otani A, Angad J, Mitani T, Posey JE, Pehlivan D, Calame D, Aydin H, Yesilbas O, Parks KC, Argilli E, England E, Im K, Taranath A, Scott HS, Barnett CP, Arts P, Sherr EH, Lupski JR, Walsh CA. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Dev Cell. 2022 10 24; 57(20):2381-2396.e13.
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Jordan KR, Hall JK, Schedin T, Borakove M, Xian JJ, Dzieciatkowska M, Lyons TR, Schedin P, Hansen KC, Borges VF. Extracellular vesicles from young women's breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach. Breast Cancer Res. 2020 11 23; 22(1):128.
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Wilburn DT, Machek SB, Cardaci TD, Willoughby DS. Carbohydrate-Induced Insulin Signaling Activates Focal Adhesion Kinase: A Nutrient and Mechanotransduction Crossroads. Nutrients. 2020 Oct 15; 12(10).
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Gerber DE, Camidge DR, Morgensztern D, Cetnar J, Kelly RJ, Ramalingam SS, Spigel DR, Jeong W, Scaglioni PP, Zhang S, Li M, Weaver DT, Vaikus L, Keegan M, Horobin JC, Burns TF. Phase 2 study of the focal adhesion kinase inhibitor defactinib (VS-6063) in previously treated advanced KRAS mutant non-small cell lung cancer. Lung Cancer. 2020 01; 139:60-67.
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Lu S, Weiser-Evans MCM. Nuclear Focal Adhesion Kinase. Circ Res. 2019 07 05; 125(2):167-169.
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Begum A, Ewachiw T, Jung C, Huang A, Norberg KJ, Marchionni L, McMillan R, Penchev V, Rajeshkumar NV, Maitra A, Wood L, Wang C, Wolfgang C, DeJesus-Acosta A, Laheru D, Shapiro IM, Padval M, Pachter JA, Weaver DT, Rasheed ZA, Matsui W. The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma. PLoS One. 2017; 12(7):e0180181.
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Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, Ye X, Davidson MW, Lammerding J, Odde DJ, Dunn AR, Weaver VM. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell. 2017 Jun 01; 28(11):1467-1488.
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