 Myosins
"Myosins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
| Descriptor ID |
D009218
|
| MeSH Number(s) |
D05.750.078.730.475 D08.811.277.040.025.193.750 D12.776.210.500.600 D12.776.220.525.475
|
| Concept/Terms |
Myosins- Myosins
- Adenosine Triphosphatase, Myosin
- Myosin Adenosine Triphosphatase
- Adenosinetriphosphatase, Myosin
- Myosin ATPase
- ATPase, Myosin
- Myosin
- Myosin Adenosinetriphosphatase
- Actin-Activated ATPase
- Actin Activated ATPase
- ATPase, Actin-Activated
- ATPase, Actin Activated
|
Below are MeSH descriptors whose meaning is more general than "Myosins".
Below are MeSH descriptors whose meaning is more specific than "Myosins".
This graph shows the total number of publications written about "Myosins" by people in this website by year, and whether "Myosins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 7 | 1 | 8 | | 1995 | 1 | 2 | 3 | | 1996 | 0 | 1 | 1 | | 1997 | 5 | 4 | 9 | | 1998 | 1 | 1 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 2 | 1 | 3 | | 2003 | 0 | 2 | 2 | | 2008 | 1 | 2 | 3 | | 2009 | 3 | 1 | 4 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 2 | 2 | | 2019 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 2 | 2 | | 2023 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Myosins" by people in Profiles.
-
Barefield DY, Tonino P, Woulfe KC, Rahmanseresht S, O'Leary TS, Burnham HV, Wasserstrom JA, Kirk JA, Previs MJ, Granzier HL, McNally EM. Myosin-binding protein H-like regulates myosin-binding protein distribution and function in atrial cardiomyocytes. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2314920120.
-
Meller A, Lotthammer JM, Smith LG, Novak B, Lee LA, Kuhn CC, Greenberg L, Leinwand LA, Greenberg MJ, Bowman GR. Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains. Elife. 2023 01 27; 12.
-
Serban KA, Pratte KA, Strange C, Sandhaus RA, Turner AM, Beiko T, Spittle DA, Maier L, Hamzeh N, Silverman EK, Hobbs BD, Hersh CP, DeMeo DL, Cho MH, Bowler RP. Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. EBioMedicine. 2022 Oct; 84:104262.
-
Lehman SJ, Crocini C, Leinwand LA. Targeting the sarcomere in inherited cardiomyopathies. Nat Rev Cardiol. 2022 06; 19(6):353-363.
-
Tang H, Cui M, Han M. Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis. Cell Rep. 2021 08 17; 36(7):109539.
-
Santos-Cortez RLP, Yarza TKL, Bootpetch TC, Tantoco MLC, Mohlke KL, Cruz TLG, Chiong Perez ME, Chan AL, Lee NR, Tobias-Grasso CAM, Reyes-Quintos MRT, Cutiongco-de la Paz EM, Chiong CM. Identification of Novel Candidate Genes and Variants for Hearing Loss and Temporal Bone Anomalies. Genes (Basel). 2021 04 13; 12(4).
-
Moore JM, Thompson TN, Glaser MA, Betterton MD. Collective motion of driven semiflexible filaments tuned by soft repulsion and stiffness. Soft Matter. 2020 Oct 28; 16(41):9436-9442.
-
Coleman JR, Moore EE, Zilberman-Rudenko J, Samuels JM, Cohen MJ, Silliman CC, Banerjee A, Sauaia A, Griffin JH, Deguchi H. Cardiac and Skeletal Muscle Myosin Exert Procoagulant Effects. Shock. 2019 11; 52(5):554-555.
-
Vera CD, Johnson CA, Walklate J, Adhikari A, Svicevic M, Mijailovich SM, Combs AC, Langer SJ, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. J Biol Chem. 2019 11 15; 294(46):17451-17462.
-
Furnish M, Caino MC. Altered mitochondrial trafficking as a novel mechanism of cancer metastasis. Cancer Rep (Hoboken). 2020 02; 3(1):e1157.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|