 Utrophin
"Utrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomally-encoded 376-kDa cytoskeletal protein that is similar in structure and function to DYSTROPHIN. It is a ubiquitously-expressed protein that plays a role in anchoring the CYTOSKELETON to the PLASMA MEMBRANE.
| Descriptor ID |
D049411
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| MeSH Number(s) |
D12.776.220.987 D12.776.543.985
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| Concept/Terms |
Utrophin- Utrophin
- UTRN Protein
- Dystrophin-Related Protein
- Dystrophin Related Protein
- Dystrophin-Related Protein 1
- Dystrophin Related Protein 1
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Below are MeSH descriptors whose meaning is more general than "Utrophin".
Below are MeSH descriptors whose meaning is more specific than "Utrophin".
This graph shows the total number of publications written about "Utrophin" by people in this website by year, and whether "Utrophin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2015 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Utrophin" by people in Profiles.
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Gorokhova S, Schessl J, Zou Y, Yang ML, Heydemann PT, Sufit RL, Meilleur K, Donkervoort S, Medne L, Finkel RS, B?nnemann CG. Unusually severe muscular dystrophy upon in-frame deletion of the dystrophin rod domain and lack of compensation by membrane-localized utrophin. Med. 2023 04 14; 4(4):245-251.e3.
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Singh SM, Bandi S, Mallela KMG. The N-Terminal Flanking Region Modulates the Actin Binding Affinity of the Utrophin Tandem Calponin-Homology Domain. Biochemistry. 2017 05 23; 56(20):2627-2636.
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Singh SM, Bandi S, Mallela KM. The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains. Biochemistry. 2015 Nov 24; 54(46):6942-50.
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Bandi S, Singh SM, Mallela KM. Interdomain Linker Determines Primarily the Structural Stability of Dystrophin and Utrophin Tandem Calponin-Homology Domains Rather than Their Actin-Binding Affinity. Biochemistry. 2015 Sep 08; 54(35):5480-8.
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Bandi S, Singh SM, Mallela KM. The C-terminal domain of the utrophin tandem calponin-homology domain appears to be thermodynamically and kinetically more stable than the full-length protein. Biochemistry. 2014 Apr 15; 53(14):2209-11.
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Singh SM, Bandi S, Winder SJ, Mallela KM. The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry. 2014 Mar 25; 53(11):1801-9.
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Marshall JL, Holmberg J, Chou E, Ocampo AC, Oh J, Lee J, Peter AK, Martin PT, Crosbie-Watson RH. Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration. J Cell Biol. 2012 Jun 25; 197(7):1009-27.
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Singh SM, Molas JF, Kongari N, Bandi S, Armstrong GS, Winder SJ, Mallela KM. Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin. Proteins. 2012 May; 80(5):1377-92.
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Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH. Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy. Hum Mol Genet. 2009 Jan 15; 18(2):318-27.
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Peter AK, Marshall JL, Crosbie RH. Sarcospan reduces dystrophic pathology: stabilization of the utrophin-glycoprotein complex. J Cell Biol. 2008 Nov 03; 183(3):419-27.
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