 Pore Forming Cytotoxic Proteins
"Pore Forming Cytotoxic Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES.
| Descriptor ID |
D052899
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| MeSH Number(s) |
D12.776.543.695
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pore Forming Cytotoxic Proteins".
Below are MeSH descriptors whose meaning is more specific than "Pore Forming Cytotoxic Proteins".
This graph shows the total number of publications written about "Pore Forming Cytotoxic Proteins" by people in this website by year, and whether "Pore Forming Cytotoxic Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2001 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2012 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2020 | 2 | 0 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pore Forming Cytotoxic Proteins" by people in Profiles.
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Rawat K, Jakubzick CV. Channeling antigens to CD8+ T cells. Science. 2023 06 23; 380(6651):1218-1219.
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Washington C, Dapas M, Biddanda A, Magnaye KM, Aneas I, Helling BA, Szczesny B, Boorgula MP, Taub MA, Kenny E, Mathias RA, Barnes KC, Khurana Hershey GK, Kercsmar CM, Gereige JD, Makhija M, Gruchalla RS, Gill MA, Liu AH, Rastogi D, Busse W, Gergen PJ, Visness CM, Gold DR, Hartert T, Johnson CC, Lemanske RF, Martinez FD, Miller RL, Ownby D, Seroogy CM, Wright AL, Zoratti EM, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Nobrega MA, Altman MC, Jackson DJ, Gern JE, McKennan CG, Ober C. African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans. Genome Med. 2022 09 29; 14(1):112.
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Nelson N, Opene B, Ernst RK, Schwartz DK. Antimicrobial peptide activity is anticorrelated with lipid a leaflet affinity. PLoS One. 2020; 15(11):e0242907.
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Wheatley EG, Curtis BJ, Hulsebus HJ, Boe DM, Najarro K, Ir D, Robertson CE, Choudhry MA, Frank DN, Kovacs EJ. Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice. Shock. 2020 01; 53(1):71-77.
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McCormack R, Bahnan W, Shrestha N, Boucher J, Barreto M, Barrera CM, Dauer EA, Freitag NE, Khan WN, Podack ER, Schesser K. Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen. Infect Immun. 2016 Apr; 84(4):1083-1091.
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Capitini CM, Nasholm NM, Duncan BB, Guimond M, Fry TJ. Graft-versus-host disease impairs vaccine responses through decreased CD4+ and CD8+ T cell proliferation and increased perforin-mediated CD8+ T cell apoptosis. J Immunol. 2013 Feb 01; 190(3):1351-9.
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Heckman KL, Schenk EL, Radhakrishnan S, Pavelko KD, Hansen MJ, Pease LR. Fast-tracked CTL: rapid induction of potent anti-tumor killer T cells in situ. Eur J Immunol. 2007 Jul; 37(7):1827-35.
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Fuller CL, Ruthel G, Warfield KL, Swenson DL, Bosio CM, Aman MJ, Bavari S. NKp30-dependent cytolysis of filovirus-infected human dendritic cells. Cell Microbiol. 2007 Apr; 9(4):962-76.
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Warfield KL, Perkins JG, Swenson DL, Deal EM, Bosio CM, Aman MJ, Yokoyama WM, Young HA, Bavari S. Role of natural killer cells in innate protection against lethal ebola virus infection. J Exp Med. 2004 Jul 19; 200(2):169-79.
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Dobbs C, Haskins K. Comparison of a T cell clone and of T cells from a TCR transgenic mouse: TCR transgenic T cells specific for self-antigen are atypical. J Immunol. 2001 Feb 15; 166(4):2495-504.
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