 Dual-Specificity Phosphatases
"Dual-Specificity Phosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which cleaves phosphate ester bonds on SERINE or THREONINE residues that are located on the same protein.
| Descriptor ID |
D054637
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| MeSH Number(s) |
D08.811.277.352.650.625.225 D08.811.277.352.650.775.250 D08.811.641.755 D12.644.360.268 D12.776.476.268
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| Concept/Terms |
Dual-Specificity Phosphatases- Dual-Specificity Phosphatases
- Dual Specificity Phosphatases
- Phosphatases, Dual-Specificity
- Dual-Specificity Phosphatase
- Dual Specificity Phosphatase
- Phosphatase, Dual-Specificity
- DUSP Phosphatases
- Phosphatases, DUSP
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Below are MeSH descriptors whose meaning is more general than "Dual-Specificity Phosphatases".
Below are MeSH descriptors whose meaning is more specific than "Dual-Specificity Phosphatases".
This graph shows the total number of publications written about "Dual-Specificity Phosphatases" by people in this website by year, and whether "Dual-Specificity Phosphatases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dual-Specificity Phosphatases" by people in Profiles.
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Ferguson BS, Wennersten SA, Demos-Davies KM, Rubino M, Robinson EL, Cavasin MA, Stratton MS, Kidger AM, Hu T, Keyse SM, McKnight RA, Lane RH, Nozik ES, Weiser-Evans MCM, McKinsey TA. DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy. Am J Physiol Heart Circ Physiol. 2021 08 01; 321(2):H382-H389.
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Choi JH, Burke JM, Szymanik KH, Nepal U, Battenhouse A, Lau JT, Stark A, Lam V, Sullivan CS. DUSP11-mediated control of 5'-triphosphate RNA regulates RIG-I sensitivity. Genes Dev. 2020 12 01; 34(23-24):1697-1712.
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Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS. DUSP5 functions as a feedback regulator of TNFa-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes. Sci Rep. 2017 10 10; 7(1):12879.
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Burke JM, Sullivan CS. DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells. RNA Biol. 2017 11 02; 14(11):1457-1465.
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Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 2017 05 04; 20(5):706-719.e7.
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Burke JM, Kincaid RP, Nottingham RM, Lambowitz AM, Sullivan CS. DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs. Genes Dev. 2016 09 15; 30(18):2076-2092.
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Liu R, van Berlo JH, York AJ, Vagnozzi RJ, Maillet M, Molkentin JD. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circ Res. 2016 07 08; 119(2):249-60.
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Slattery ML, Lundgreen A, John EM, Torres-Mejia G, Hines L, Giuliano AR, Baumgartner KB, Stern MC, Wolff RK. MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study. Nutr Cancer. 2015; 67(2):292-304.
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Ferguson BS, Harrison BC, Jeong MY, Reid BG, Wempe MF, Wagner FF, Holson EB, McKinsey TA. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9806-11.
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Weise SE, Aung K, Jarou ZJ, Mehrshahi P, Li Z, Hardy AC, Carr DJ, Sharkey TD. Engineering starch accumulation by manipulation of phosphate metabolism of starch. Plant Biotechnol J. 2012 Jun; 10(5):545-54.
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