 Werner Syndrome Helicase
"Werner Syndrome Helicase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
| Descriptor ID |
D000071657
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| MeSH Number(s) |
D08.811.277.040.025.159.249.500 D08.811.277.352.335.375.875 D08.811.277.352.365.290.500 D08.811.399.340.249.500 D12.776.157.687.750 D12.776.660.720.750
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| Concept/Terms |
Werner Syndrome Helicase- Werner Syndrome Helicase
- Helicase, Werner Syndrome
- Werner Syndrome ATP-Dependent Helicase
- Werner Syndrome ATP Dependent Helicase
- RECQL2 Protein
- Werner Syndrome RecQ-Like Helicase
- Werner Syndrome RecQ Like Helicase
- RECQ3 Protein
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Below are MeSH descriptors whose meaning is more general than "Werner Syndrome Helicase".
Below are MeSH descriptors whose meaning is more specific than "Werner Syndrome Helicase".
This graph shows the total number of publications written about "Werner Syndrome Helicase" by people in this website by year, and whether "Werner Syndrome Helicase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Werner Syndrome Helicase" by people in Profiles.
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Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015 Jun 05; 348(6239):1160-3.
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Arnoult N, Saintome C, Ourliac-Garnier I, Riou JF, Londo?o-Vallejo A. Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev. 2009 Dec 15; 23(24):2915-24.
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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80.
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Grandori C, Robinson KL, Galloway DA, Swisshelm K. Functional link between Myc and the Werner gene in tumorigenesis. Cell Cycle. 2004 Jan; 3(1):22-5.
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Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 2003 Jul 01; 17(13):1569-74.
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