 NLR Proteins
"NLR Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.
| Descriptor ID |
D000070576
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| MeSH Number(s) |
D12.644.360.539
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| Concept/Terms |
NLR Proteins- NLR Proteins
- Proteins, NLR
- NLR Protein
- Protein, NLR
- NOD-like Receptors
- NOD like Receptors
- Receptors, NOD-like
- Nucleotide-binding Domain Leucine-rich Repeat Proteins
- Nucleotide binding Domain Leucine rich Repeat Proteins
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Below are MeSH descriptors whose meaning is more general than "NLR Proteins".
Below are MeSH descriptors whose meaning is more specific than "NLR Proteins".
This graph shows the total number of publications written about "NLR Proteins" by people in this website by year, and whether "NLR Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "NLR Proteins" by people in Profiles.
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Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT. Bacterial NLR-related proteins protect against phage. Cell. 2023 05 25; 186(11):2410-2424.e18.
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Spritz RA, Andersen GH. Genetics of Vitiligo. Dermatol Clin. 2017 Apr; 35(2):245-255.
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Zhai Z, Liu W, Kaur M, Luo Y, Domenico J, Samson JM, Shellman YG, Norris DA, Dinarello CA, Spritz RA, Fujita M. NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma. Oncogene. 2017 07 06; 36(27):3820-3830.
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Levandowski CB, Mailloux CM, Ferrara TM, Gowan K, Ben S, Jin Y, McFann KK, Holland PJ, Fain PR, Dinarello CA, Spritz RA. NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1? processing via the NLRP1 inflammasome. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2952-6.
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Spritz RA. Recent progress in the genetics of generalized vitiligo. J Genet Genomics. 2011 Jul 20; 38(7):271-8.
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Jin Y, Riccardi SL, Gowan K, Fain PR, Spritz RA. Fine-mapping of vitiligo susceptibility loci on chromosomes 7 and 9 and interactions with NLRP1 (NALP1). J Invest Dermatol. 2010 Mar; 130(3):774-83.
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Jin Y, Birlea SA, Fain PR, Spritz RA. Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J Invest Dermatol. 2007 Nov; 127(11):2558-62.
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Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, Spritz RA. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med. 2007 Mar 22; 356(12):1216-25.
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