 Janus Kinases
"Janus Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
| Descriptor ID |
D053612
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| MeSH Number(s) |
D08.811.913.696.620.682.725.124 D12.776.476.393
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Janus Kinases".
Below are MeSH descriptors whose meaning is more specific than "Janus Kinases".
This graph shows the total number of publications written about "Janus Kinases" by people in this website by year, and whether "Janus Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2013 | 0 | 2 | 2 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Janus Kinases" by people in Profiles.
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Guttman-Yassky E, Irvine AD, Brunner PM, Kim BS, Boguniewicz M, Parmentier J, Platt AM, Kabashima K. The role of Janus kinase signaling in the pathology of atopic dermatitis. J Allergy Clin Immunol. 2023 12; 152(6):1394-1404.
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Roach CM, Bidne KL, Romoser MR, Ross JW, Baumgard LH, Keating AF. Impact of heat stress on prolactin-mediated ovarian JAK-STAT signaling in postpubertal gilts. J Anim Sci. 2022 Jul 01; 100(7).
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Sabaawy HE, Ryan BM, Khiabanian H, Pine SR. JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance. Carcinogenesis. 2021 12 31; 42(12):1411-1419.
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Peron M, Dinarello A, Meneghetti G, Martorano L, Betto RM, Facchinello N, Tesoriere A, Tiso N, Martello G, Argenton F. Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation. Development. 2021 09 01; 148(17).
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Benamu E. Infectious Risks Associated with Biologics Targeting Janus Kinase-Signal Transducer and Activator of Transcription Signaling and Complement Pathway for Inflammatory Diseases. Infect Dis Clin North Am. 2020 06; 34(2):271-310.
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Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. BMC Genomics. 2019 Aug 28; 20(1):677.
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Lu S, Natarajan SK, Mott JL, Kharbanda KK, Harrison-Findik DD. Ceramide Induces Human Hepcidin Gene Transcription through JAK/STAT3 Pathway. PLoS One. 2016; 11(1):e0147474.
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Kaplan JB, Stein BL, McMahon B, Giles FJ, Platanias LC. Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative Neoplasms. EBioMedicine. 2016 Jan; 3:17-25.
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Fry TJ, Aplan PD. A robust in vivo model for B cell precursor acute lymphoblastic leukemia. J Clin Invest. 2015 Sep; 125(9):3427-9.
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Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA receptor expression after differing severities of experimental TBI. Exp Neurol. 2015 Sep; 271:445-56.
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